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Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.
👥 作者
Xie Tian (Guangzhou National Laboratory)
Ani Alireza (No. 9 XingDaoHuanBei Road)
Vaez Ahmad (Guangzhou International Bio Island)
Nolte Ilja M (Guangzhou 510005)
Su Shaoyong (Guangdong Province)
Ishikuro Mami (China.; Department of Epidemiology)
Wang Siqi (University of Groningen)
Zhang Wenbo (University Medical Center Groningen)
Soares Ana Goncalves (PO Box 30.001)
Motazedi Ehsan (9700 RB Groningen)
Calas Lucinda (The Netherlands.; Department of Epidemiology)
Ronkainen Justiina (University of Groningen)
Pedersen Casper-Emil T (University Medical Center Groningen)
Lu Xueling (PO Box 30.001)
Stinson Sara E (9700 RB Groningen)
Felix Janine F (The Netherlands.; Department of Epidemiology)
Stankevic Evelina (University of Groningen)
Wang Carol A (University Medical Center Groningen)
Thiering Elisabeth (PO Box 30.001)
Fernández Dietmar (9700 RB Groningen)
Calvo-Serra Beatriz (The Netherlands.; Georgia Prevention Institute)
Stathopoulou Maria G (Medical College of Georgia)
Fore Ruby (Augusta University)
Kumar Ashish (Augusta)
Tuhkanen Johanna (GA)
Bilbao Jose Ramon (USA.; Department of Preventive Medicine and Epidemiology)
Ibarluzea Jesus (Tohoku Medical Megabank Organization)
Isaacs Aaron (Tohoku University)
Fonvig Cilius Esmann (Sendai)
Rivadeneira Fernando (Japan.; Department of Epidemiology)
Lund Morten Asp Vonsild (University of Groningen)
Holm Louise Aas (University Medical Center Groningen)
van der Most Peter J (PO Box 30.001)
Riese Harriëtte (9700 RB Groningen)
Narita Akira (The Netherlands.; Department of Epidemiology)
Tamiya Gen (University of Groningen)
Flexeder Claudia (University Medical Center Groningen)
Wiersma Rikstje (PO Box 30.001)
Argoty-Pantoja Anna D (9700 RB Groningen)
Vinding Rebecca (The Netherlands.; MRC Integrative Epidemiology Unit)
Hansen Tine Willum (University of Bristol)
Kümler Thomas (Bristol)
Estarlich Marisa (UK.; Department of Public and Occupational Health (POH))
Bustamante Mariona (Amsterdam UMC)
Yuan Wen Lun (Location University of Amsterdam)
Boland-Augé Anne (Amsterdam)
Deleuze Jean-François (The Netherlands.; Inserm)
Petrelis Alexandros M (INRAE)
Rifas-Shiman Sheryl (Center for Research in Epidemiology and StatisticS (CRESS))
Kajantie Eero (Université Paris Cité and Université Sorbonne Paris Nord)
Fernandez-Jimenez Nora (Paris)
Santa-Marina Loreto (France.; Research Unit of Population Health)
Arts Ilja C W (University of Oulu)
Lahti Jari (Oulu)
Strandberg Timo (Finland.; COPSAC)
Kull Inger (Copenhagen Prospective Studies on Asthma in Childhood)
Bergström Anna (Herlev and Gentofte Hospital)
Hivert Marie-France (University of Copenhagen)
Bønnelykke Klaus (Ledreborg Alle 34)
Kuriyama Shinichi (2820 Gentofte)
Beilin Lawrence J (Copenhagen)
Mori Trevor A (Denmark.; Department of Epidemiology)
Hartman Catharina A (University of Groningen)
Grarup Niels (University Medical Center Groningen)
Thijs Carel (PO Box 30.001)
Räikkönen Katri (9700 RB Groningen)
Melén Erik (The Netherlands.; Novo Nordisk Foundation Center for Basic Metabolic Research)
Oken Emily (Faculty of Health and Medical Sciences)
Visvikis-Siest Sophie (University of Copenhagen)
Gützkow Kristine B (Copenhagen)
Grazuleviciene Regina (Denmark.; The Generation R Study Group)
Heude Barbara (Erasmus MC)
Chatzi Leda (University Medical Center Rotterdam)
Vrijheid Martine (Rotterdam)
Standl Marie (the Netherlands.; Novo Nordisk Foundation Center for Basic Metabolic Research)
Vrijkotte Tanja (Faculty of Health and Medical Sciences)
Pennell Craig E (University of Copenhagen)
Oldehinkel Albertine J (Copenhagen)
Hansen Torben (Denmark.; School of Medicine and Public Health)
Jaddoe Vincent W V (University of Newcastle)
Holm Jens-Christian (Newcastle)
Sebert Sylvain (New South Wales)
Timpson Nicholas J (Australia.; Institute of Epidemiology)
Obara Taku (Helmholtz Zentrum München- German Research Center for Environmental Health)
Wang Xiaoling (Neuherberg)
Lawlor Deborah A (Germany.; Cerba Internacional)
Corpeleijn Eva (Barcelona)
Ahluwalia Tarunveer S (Spain.; ISGlobal)
Snieder Harold (Barcelona)
📋 发表信息
📖 Eur Heart J
📅 2026-01-01
🧬 PMID: 42036355
📂 分类:高血压
📝 摘要
To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (n = 28 425) and HR (n = 22 565) were conducted in children of European ancestry aged 4-17 years. Follow-up analyses included comparisons with adult GWAS results, polygenic risk score (PRS) analyses in independent cohorts of diverse ancestries, and a phenome-wide association study in the UK Biobank. Eight genome-wide significant loci were identified for childhood BP (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2) and three loci for childhood HR (CCDC141, ACHE, MYH6); all novel in children but previously reported in adults. Childhood PRSs explained up to 1.6% of BP variance and 5.2% of HR variance among children of European ancestry. Genetic correlations between childhood and adulthood BP traits were moderate (rg = 0.4-0.7), suggesting age-specific genetic effects on BP. In the UK Biobank, higher childhood BP PRS levels were significantly associated with a broad range of adult health outcomes, particularly cardiometabolic outcomes such as hypertension, angina, myocardial infarction, and cardiovascular disease-related mortality. These findings advance the understanding of the genetic architecture of childhood BP and HR and provide compelling genetic evidence linking childhood BP to a broad spectrum of adult health outcomes-particularly cardiometabolic conditions-which may inform targeted prevention strategies from a young age.
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