Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.
📚 期刊: Cardiovascular diabetology
📅 发表: 0000-00-00
🔬 PMID: 42143308 👁️ 浏览: 12
👤 作者: Han, Liu, Zhou, Liu, Guo, Hu, Gao, Zeng
心血管
📝 摘要
Cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 represent a critical window for preventing progression to overt cardiovascular disease (CVD). Insulin resistance (IR) is central to CKM pathophysiology, yet the comparative utility of longitudinal IR patterns (cumulative burden and longitudinal pattern groups) across multiple surrogates, and the mediating role of biological ageing, remain unexamined in this preclinical population.