Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation.
B, K., S, L., J, W., D, P., L, S., T, T., T, T., F, R., D, S., & P, v.S. (2026). Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation.. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Card. https://doi.org/10.4244/EIJ-D-25-01308
B K, S L, J W, D P, L S, T T, et al. Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation.. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Card. 2026; doi: 10.4244/EIJ-D-25-01308
B K, S L, J W, et al. Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation.[J]. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Card. 2026. DOI: 10.4244/EIJ-D-25-01308.
@article{b2026,
author = {Koell B and Ludwig S and Weimann J and Patel D and Stolz L and Tanaka T and Trenkwalder T and Rudolph F and Samim D and von Stein P},
title = {Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation.},
journal = {EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Card},
year = {2026},
doi = {10.4244/EIJ-D-25-01308},
note = {PMID: 42290314},
}
TY - JOUR AU - Koell B AU - Ludwig S AU - Weimann J AU - Patel D AU - Stolz L AU - Tanaka T AU - Trenkwalder T AU - Rudolph F AU - Samim D AU - von Stein P TI - Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation. T2 - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Card PY - 2026 DO - 10.4244/EIJ-D-25-01308 AN - PMID:42290314 ER -
BACKGROUND: The evolving landscape of mitral valve transcatheter edge-to-edge repair (M-TEER) for mitral regurgitation (MR) has seen continuous advancements, driving improvements in therapeutic efficacy. Particularly in primary MR (PMR), contemporary device iterations of M-TEER offer technical advantages for improved management of complex anatomies. However, data on temporal trends in M-TEER for PMR are limited. AIMS: The primary objective of our study was to analyse temporal trends in the safety, efficacy, and stability of M-TEER treatment. METHODS: The PRIME-MR registry, a retrospective multicentre study, enrolled consecutive patients undergoing M-TEER for PMR at 27 centres in Europe and North America. M-TEER procedures were categorised into four time periods (2009-2013, 2014-2016, 2017-2019, and 2020-2023), to align with major device updates. RESULTS: The analysis included 3,082 consecutive patients (median age 82 years [interquartile range 76.0-85.0], 45.1% female). Patients treated were highly symptomatic (New York Heart Association [NYHA] Class ≥III in 80.4%). Patient characteristics showed a decline in symptomatic severity (NYHA Class ≥III 85.9% in 2009-2013 vs 71.8% in 2020-2023), accompanied by lower mean Society of Thoracic Surgeons scores (5.6% [2009-2013] vs 4.6% [2020-2023]; p for trend<0.0001), and less severe MR. Over time, complication rates decreased (procedures with complications: 42.4% [2009-2013] vs 23.1% [2020-2023]; p for trend<0.0001), whereas technical efficacy increased (residual MR ≤1+: 54.0% [2009-2013] vs 68.4% [2020-2023]; p for trend<0.001). There was an increased occurrence of stable results without any deterioration at one-year follow-up (63.6% [2009-2013] vs 74.4% [2020-2023]; p for trend=0.03). CONCLUSIONS: Findings from the PRIME-MR registry highlight substantial reductions in residual MR severity and complication rates over time in PMR patients undergoing M-TEER.