Impact of Coronary Artery Disease and Revascularization on Outcomes After Transcatheter Tricuspid Edge-to-Edge Repair.
M, A.Z., E, R., A, S., T, T., J, S., J, H., M, W., S, Z., G, N., & A, A. (2026). Impact of Coronary Artery Disease and Revascularization on Outcomes After Transcatheter Tricuspid Edge-to-Edge Repair.. JACC. Cardiovascular interventions. https://doi.org/10.1016/j.jcin.2026.03.025
M AZ, E R, A S, T T, J S, J H, et al. Impact of Coronary Artery Disease and Revascularization on Outcomes After Transcatheter Tricuspid Edge-to-Edge Repair.. JACC. Cardiovascular interventions. 2026; doi: 10.1016/j.jcin.2026.03.025
M AZ, E R, A S, et al. Impact of Coronary Artery Disease and Revascularization on Outcomes After Transcatheter Tricuspid Edge-to-Edge Repair.[J]. JACC. Cardiovascular interventions. 2026. DOI: 10.1016/j.jcin.2026.03.025.
@article{m2026,
author = {Al Zaidi M and Repges E and Sugiura A and Tanaka T and Shamekhi J and Husch J and Weber M and Zimmer S and Nickenig G and Aksoy A},
title = {Impact of Coronary Artery Disease and Revascularization on Outcomes After Transcatheter Tricuspid Edge-to-Edge Repair.},
journal = {JACC. Cardiovascular interventions},
year = {2026},
doi = {10.1016/j.jcin.2026.03.025},
note = {PMID: 42191313},
}
TY - JOUR AU - Al Zaidi M AU - Repges E AU - Sugiura A AU - Tanaka T AU - Shamekhi J AU - Husch J AU - Weber M AU - Zimmer S AU - Nickenig G AU - Aksoy A TI - Impact of Coronary Artery Disease and Revascularization on Outcomes After Transcatheter Tricuspid Edge-to-Edge Repair. T2 - JACC. Cardiovascular interventions PY - 2026 DO - 10.1016/j.jcin.2026.03.025 AN - PMID:42191313 ER -
BACKGROUND: Coronary artery disease (CAD) is common in patients treated for structural heart disease, but its prevalence, prognostic impact, and optimal management in patients undergoing tricuspid transcatheter edge-to-edge repair (T-TEER) remain uncertain. OBJECTIVES: The aim of this study was to examine whether the presence of CAD, its anatomical complexity, and the extent of revascularization influence outcomes after T-TEER. METHODS: In this observational study, 361 consecutive T-TEER patients underwent preprocedural coronary angiography with SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) scoring. CAD was defined as ≥70% stenosis (≥50% for the left main coronary artery). Residual SYNTAX score was calculated if revascularization was performed. The primary endpoint was 12-month all-cause mortality. RESULTS: Obstructive CAD was present in 124 patients (34.3%), with low lesion complexity (median SYNTAX score 6; Q1-Q3: 3-9.75). Among CAD patients, 33.9% underwent revascularization, reducing the residual SYNTAX score to 4 (Q1-Q3: 2-7). During the 12-month follow-up period, 16.7% of patients died. Survival over the follow-up period did not differ significantly according to the presence of obstructive CAD, baseline SYNTAX score, or residual SYNTAX score (12-month mortality for CAD vs no CAD 17.5% vs 16.3%; log-rank P = 0.616). Interaction analysis revealed effect modification by procedural risk determined by TRI-SCORE: in patients at low and intermediate risk, elevated residual SYNTAX score was associated with lower survival over follow-up (12-month mortality 20.8% vs 6.4%; log-rank P = 0.016), whereas no association was observed in high-risk patients (27.6% vs 27.1%; log-rank P = 0.927). Adding residual SYNTAX to the TRI-SCORE improved risk stratification in low- and intermediate-risk CAD patients (ΔC = +0.099). CONCLUSIONS: Obstructive CAD is common but typically low in complexity among T-TEER candidates. In low- and intermediate-risk patients, a higher residual SYNTAX score is associated with reduced survival.