Jing, Y., Zhi, J., Matthew, A.J., Guijin, Z., Feilong, Z., Ming, Z., Can, C., Jiaofu, L., Prasanna, V., Wenlong, L., Jianwu, W., Nuan, C., Pingqiang, C., Changtai, G., Jintong, A., Yulin, Z., Sheshagiri, P.S., Huajian, G., & Xiaodong, C. (2026). Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology.. Science advances. https://doi.org/10.1126/sciadv.adz1253
Jing Y, Zhi J, Matthew AJ, Guijin Z, Feilong Z, Ming Z, et al. Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology.. Science advances. 2026; doi: 10.1126/sciadv.adz1253
Jing Y, Zhi J, Matthew AJ, et al. Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology.[J]. Science advances. 2026. DOI: 10.1126/sciadv.adz1253.
@article{jing2026,
author = {Yu Jing and Jiang Zhi and Ackers-Johnson Matthew and Zou Guijin and Zhang Feilong and Zhu Ming and Cao Can and Li Jiaofu and Vidyasekar Prasanna and Li Wenlong and Wang Jianwu and Chen Nuan and Cai Pingqiang and Guo Changtai and Ai Jintong and Zhou Yulin and Prabhu Srinivas Sheshagiri and Gao Huajian and Chen Xiaodong},
title = {Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology.},
journal = {Science advances},
year = {2026},
doi = {10.1126/sciadv.adz1253},
note = {PMID: 41499509},
}
TY - JOUR AU - Yu Jing AU - Jiang Zhi AU - Ackers-Johnson Matthew AU - Zou Guijin AU - Zhang Feilong AU - Zhu Ming AU - Cao Can AU - Li Jiaofu AU - Vidyasekar Prasanna AU - Li Wenlong AU - Wang Jianwu AU - Chen Nuan AU - Cai Pingqiang AU - Guo Changtai AU - Ai Jintong AU - Zhou Yulin AU - Prabhu Srinivas Sheshagiri AU - Gao Huajian AU - Chen Xiaodong TI - Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology. T2 - Science advances PY - 2026 DO - 10.1126/sciadv.adz1253 AN - PMID:41499509 ER -
Existing bioelectronics often exhibit megapascal-scale moduli, despite the mechanosensitive nature of cardiomyocytes. Bridging the mechanical mismatch between tissue and bioelectronics is indispensable for building physiologically relevant in vitro cardiac models and advancing therapies. Here, we present Pliable Ultrathin Layered Sensing Electronics (PULSE), a platform with tissue-matched modulus (~10 kilopascals) and stretchable gold microcircuitry for long-term, high-fidelity monitoring of cardiac electrophysiology in vitro. Composed of a soft gel matrix and an ultrathin nanofilm embedded with gold circuits, our device achieves unprecedented tissue integration and preserves natural cardiomyocyte mechanics, resulting in a 140% increase in mechanical contraction and a 100% increase in electrical signals compared to conventional electronics. Cardiac tissue that grows our device exhibited enhanced drug sensitivity and response in cardiac dysfunction, revolutionizing disease modeling. By facilitating seamless interaction at the tissue-electronic interface, our platform offers a transformative perspective for advancing cardiac modeling and next-generation bioelectronic applications.