https://heart.lihaiyang.com 心血管文献检索平台 - 最新收录论文 zh-CN https://heart.lihaiyang.com/?p=detail&id=196 For patients undergoing surgical valve procedures with concomitant coronary artery disease, current guidelines recommend that coronary artery bypass grafting (CABG) should be anatomically guided on the basis of stenosis severity, as assessed by coronary angiography. We aimed to test whether a physio Sat, 21 Mar 2026 00:00:00 +0800 冠心病 https://doi.org/10.1016/S0140-6736(25)02418-3 https://heart.lihaiyang.com/?p=detail&id=185 暂无摘要 Fri, 20 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1093/eurheartj/ehag177 https://heart.lihaiyang.com/?p=detail&id=186 暂无摘要 Fri, 20 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1093/eurheartj/ehag208 https://heart.lihaiyang.com/?p=detail&id=187 Preclinical evidence suggests that time-restricted eating (TRE) exerts beneficial metabolic and cardiovascular effects by ameliorating inflammation and modulating immune cell function. However, the effect in patients with established coronary artery disease remains unknown. In this prospective, rand Fri, 20 Mar 2026 00:00:00 +0800 心肌病 https://doi.org/10.1161/JAHA.125.048092 https://heart.lihaiyang.com/?p=detail&id=188 Stressor-associated atrial fibrillation (AF) refers to new-onset AF that occurs with a reversible, acute stressor. Identifying individuals at highest risk for AF recurrence is essential to guide management. Although clinical factors have shown limited value, the utility of contemporary artificial in Fri, 20 Mar 2026 00:00:00 +0800 房颤 https://doi.org/10.1161/JAHA.125.047146 https://heart.lihaiyang.com/?p=detail&id=189 Environmental pollution - including air, noise, and light - and progressive climate change are major contributors to global health burdens, responsible for over 9 million premature deaths annuallysa. Among environmental exposures, air and noise pollution show the strongest epidemiological links to h Fri, 20 Mar 2026 00:00:00 +0800 高血压 https://doi.org/10.1093/cvr/cvag061 https://heart.lihaiyang.com/?p=detail&id=190 Despite accounting for a substantial proportion of the global population and disease burden, African countries are underrepresented in randomized controlled trials (RCTs), including those informing cardiovascular (CV) care. In this study, we sought to quantify African representation in RCTs publishe Fri, 20 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1016/j.jacc.2026.02.5097 https://heart.lihaiyang.com/?p=detail&id=191 Given the persistently high morbidity and mortality of heart failure (HF), targeting myocardial remodeling, particularly pathological hypertrophy and fibrosis, has become a major therapeutic priority. RhoA (Ras homolog gene family member A), a small GTPase governing cytoskeletal reorganization and c Fri, 20 Mar 2026 00:00:00 +0800 心衰 https://doi.org/10.1161/CIRCRESAHA.125.327107 https://heart.lihaiyang.com/?p=detail&id=192 Contractile dysfunction, hypertrophy, and cell death during heart failure are linked to altered Ca Mice received 1-week infusions of AngII, bisperoxovanadium 1,10 phenanthroline, both, or saline via osmotic minipumps. We used mass spectrometry, super-resolution microscopy, electrophysiology, confoca Fri, 20 Mar 2026 00:00:00 +0800 心衰 https://doi.org/10.1161/CIRCRESAHA.125.327896 https://heart.lihaiyang.com/?p=detail&id=193 Genetic testing has become an integral part of the diagnostic workup of patients with dilated cardiomyopathy (DCM). While the initial goal of genetic testing was to identify family members at risk, recent advances have now extended their relevance to clinical decision-making. Our knowledge of the ge Fri, 20 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1093/eurheartj/ehag159 https://heart.lihaiyang.com/?p=detail&id=194 暂无摘要 Fri, 20 Mar 2026 00:00:00 +0800 心衰 https://doi.org/10.1093/ejhf/xuag086 https://heart.lihaiyang.com/?p=detail&id=195 Aberrant and excessive cardiac fibrosis contributes to heart failure. Resident cardiac fibroblasts are the primary source of myofibroblasts that produce extracellular matrix proteins to mediate cardiac fibrosis. Previous studies have implicated suppressor of variegation 3-9 homolog 1 (Suv39h1), a ly Fri, 20 Mar 2026 00:00:00 +0800 心衰 https://doi.org/10.1093/cvr/cvag066 https://heart.lihaiyang.com/?p=detail&id=177 We investigated the role of Lgi3-4 proteins in cardiac electrophysiology, with a specific focus on IKur, and their potential contribution to the pathophysiology of atrial fibrillation (AF). In human atrial tissue and heterologous cells, Lgi3 and Lgi4 interacted with KV1.5 channels. In a mouse model Thu, 19 Mar 2026 00:00:00 +0800 房颤 https://doi.org/10.1093/cvr/cvag049 https://heart.lihaiyang.com/?p=detail&id=178 高甘油三酯血症是动脉粥样硬化性心血管疾病的既定危险因素，最近被牵连在腹主动脉瘤的发病机制中。然而，其在胸主动脉瘤和夹层（TAAD）中的作用仍不确定。本研究利用GPIHBP1（糖基磷脂酰肌醇锚定高密度脂蛋白结合蛋白1）基因敲除小鼠作为高甘油三酯血症模型，探讨了高甘油三酯血症对实验性TAAD的影响。通过口服β-氨基丙腈在3-4周龄小鼠中诱导TAAD，持续28天。尽管GPIHBP1基因敲除小鼠在β-氨基丙腈治疗期间表现出进行性高甘油三酯血症，但与野生型同窝小鼠相比，TAAD发生率、死亡率或受累主动脉节段与主动脉全长之比均无显著差异。组织病理学和分子分析显示，两种基因型小鼠胸主动脉的弹性蛋白断裂、细胞 Thu, 19 Mar 2026 00:00:00 +0800 血脂 https://doi.org/10.1161/ATVBAHA.126.324300 https://heart.lihaiyang.com/?p=detail&id=179 动脉压力波形形状传达了左心室和主动脉之间相互作用的信息，可提供生物学心脏年龄和心血管疾病风险的估计。人工智能心脏年龄（AI-HA）通过平均两个卷积神经网络的预测结果来估计，这些网络使用未校准的动脉张力测量或光电容积脉搏波波形作为输入，预测二尖瓣环组织多普勒e'和s'峰值速度。模型使用Framingham心脏研究参与者压力波形和超声心动图测量数据开发（N=6916名参与者，38174个波形，56%女性，平均年龄61±12岁）。在FHS基线桡动脉波形保留集（N=7018，54%女性，年龄50±16岁）和UK Biobank参与者（N=67986，53%女性，年龄57±8岁）中验证了AI-HA。在F Thu, 19 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1161/HYPERTENSIONAHA.125.26209 https://heart.lihaiyang.com/?p=detail&id=180 房性早搏是最常见的心律失常之一，频繁的房性早搏可增加房颤、卒中和心力衰竭的风险，但目前尚无批准的特异性治疗药物。本研究为一项II期随机临床试验，旨在评估美金刚（一种NMDA受体拮抗剂）治疗房性早搏的疗效和安全性。美金刚通过阻断NMDA受体介导的过度交感神经激活，理论上可以减少房性异位激动。研究纳入了频繁房性早搏患者，随机分配至美金刚治疗组和安慰剂组，通过24小时动态心电图评估房性早搏负荷变化。主要终点为治疗8周后房性早搏减少的百分比。该研究为房性早搏的药物治疗提供了新的思路，如果证实有效，美金刚可能成为首个专门针对房性早搏的治疗药物，具有重要的临床意义。 Thu, 19 Mar 2026 00:00:00 +0800 心律失常 https://doi.org/10.1161/CIRCULATIONAHA.125.079023 https://heart.lihaiyang.com/?p=detail&id=181 高血压是心血管疾病、卒中、慢性肾病和过早死亡的首要可改变危险因素。虽然血管紧张素原是肾素-血管紧张素-醛固酮系统的核心组成部分，但历史上主要将其视为生化底物而非血压的主动调节因子，与血管紧张素转换酶和血管紧张素II受体等下游成分相比，作为治疗靶点的关注度较低。然而，新出现的证据突出了其在血压调节中的动态、组织特异性作用及其对代谢、激素和炎症刺激的应答。本综述检查了血管紧张素原的分子生物学、结构-功能关系和调节机制，包括M235T和-6G>A等遗传变异对个体和群体水平高血压易感性的贡献。进一步探讨了血管紧张素原在盐敏感性高血压、肥胖相关炎症和肾素-血管紧张素-醛固酮系统逃逸现象中的致病作用。最近 Thu, 19 Mar 2026 00:00:00 +0800 高血压 https://doi.org/10.1161/HYPERTENSIONAHA.125.26091 https://heart.lihaiyang.com/?p=detail&id=182 胸主动脉夹层是一种高发病率和高死亡率的急性血管疾病。内皮细胞对维持血管稳态至关重要，但内皮-间充质转化在胸主动脉夹层中的作用尚不明确。PDK4（丙酮酸脱氢酶激酶4）作为这一病理细胞命运转换驱动因素的功能也未被阐明。本研究整合了人体主动脉标本和β-氨基丙腈诱导小鼠模型的转录组分析和免疫荧光分析，通过RNA测序和染色质免疫沉淀测定鉴定PDK4为内皮-间充质转化信号的关键下游效应因子。研究发现，转录因子SNAI1直接结合PDK4启动子激活其表达，过量的PDK4通过乳酸积累促进内皮-间充质转化，建立了PDK4-EndoMT正反馈环路。体内实验中，内皮特异性Pdk4过表达可自发引起主动脉夹层和破裂，而内 Thu, 19 Mar 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/ATVBAHA.125.324031 https://heart.lihaiyang.com/?p=detail&id=183 主动脉夹层是一种危及生命的疾病，涉及血管平滑肌细胞从收缩表型向合成表型的病理性转换。尽管运动具有广泛的心血管益处，但其在主动脉夹层发病机制中的作用尚不清楚。本研究旨在确定运动是否通过调节血管平滑肌细胞表型来减轻主动脉夹层，并阐明其潜在的分子机制。在人体主动脉夹层病变组织中，收缩型血管平滑肌细胞标志物（MYH11、CNN1和α-SMA）显著下调，而合成标志物骨桥蛋白上调。在β-氨基丙腈诱导的主动脉夹层小鼠模型中，运动提高了生存率，减少了主动脉扩张和夹层发生率，并维持了血管平滑肌细胞的收缩表型。RNA测序分析将PDE5A鉴定为关键的应答运动基因。血管平滑肌细胞特异性过表达PDE5A可减轻夹层进展， Thu, 19 Mar 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/ATVBAHA.125.324293 https://heart.lihaiyang.com/?p=detail&id=184 外科主动脉瓣置换术一直是有症状重度退行性主动脉瓣狭窄患者的标准治疗方案。近年来，经导管主动脉瓣置换术在特定患者群体中已成为成熟的替代治疗方案，在三叶瓣狭窄方面有强有力的循证支持。然而，经导管主动脉瓣置换术在二叶主动脉瓣狭窄中的评估仍有限。最近，多项观察性研究证实了经导管主动脉瓣置换术在二叶主动脉瓣狭窄中的可行性和安全性，新一代器械的使用显示出令人鼓舞的结果。然而，与三叶瓣狭窄相比，二叶主动脉瓣狭窄患者中瓣周反流、永久性起搏器植入和主动脉根部损伤等手术并发症的发生率更高。本文综述了经导管主动脉瓣置换术治疗二叶主动脉瓣狭窄的临床证据，并就患者和器械选择、植入技术及进一步管理的适当标准提出了建议。 Thu, 19 Mar 2026 00:00:00 +0800 心脏瓣膜 https://doi.org/10.1161/CIRCINTERVENTIONS.125.016014 https://heart.lihaiyang.com/?p=detail&id=175 Patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of subsequent stroke that persists for at least 10 years. We aimed to identify prognostic factors associated with long-term risk of stroke in this patient group, and estimate their population attribution fraction Wed, 18 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1161/CIRCULATIONAHA.125.078763 https://heart.lihaiyang.com/?p=detail&id=176 Catheter-based closure of the left atrial appendage is an alternative to oral anticoagulation for stroke prevention in patients with atrial fibrillation. The effectiveness of this strategy, as compared with physician-directed best medical care, in patients at high risk for stroke and bleeding is unk Wed, 18 Mar 2026 00:00:00 +0800 房颤 https://doi.org/10.1056/NEJMoa2513310 https://heart.lihaiyang.com/?p=detail&id=173 Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. In this multicenter, open-label trial, we randomly assigned patients who had acute hypoxemi Tue, 17 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1056/NEJMoa2516087 https://heart.lihaiyang.com/?p=detail&id=174 On the basis of seminal genetic discoveries, proprotein convertase subtilisin/kexin Type 9 (PCSK9) inhibitors were developed as a new class of LDL cholesterol-lowering drug, with a potency on par with and on top of high-intensity statins and an excellent safety profile. A series of large cardiovascu Tue, 17 Mar 2026 00:00:00 +0800 血脂 https://doi.org/10.1093/eurheartj/ehag148 https://heart.lihaiyang.com/?p=detail&id=172 暂无摘要 Mon, 16 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1016/S0140-6736(26)00419-8 https://heart.lihaiyang.com/?p=detail&id=171 绝经后女性心血管疾病的发病率急剧上升，尤其是冠心病，已成为全球女性面临的主要健康问题。以往的观点认为，雌激素水平下降是绝经后女性风险升高的主要原因。近年来，越来越多的证据表明，绝经后水平急剧升高的促卵泡激素（FSH）可能在此过程中发挥关键作用。本文系统总结了来自临床和动物研究的现有证据，评估了FSH与绝经后女性冠心病风险之间的关系，探索了相互矛盾的证据，并检查了其在动脉粥样硬化发病机制和心脏代谢风险因素调节中的潜在作用。多项研究证实，升高的FSH通过结合肝脏和炎症细胞中的促卵泡激素受体（FSHR），干扰脂质代谢并加剧血管炎症，从而促进冠心病的进展。流行病学证据也支持这一观点。然而，一些临床研究 Fri, 13 Mar 2026 00:00:00 +0800 冠心病 https://doi.org/10.2147/IJWH.S571490 https://heart.lihaiyang.com/?p=detail&id=170 准确估计低密度脂蛋白胆固醇（LDL-C）对于心血管风险评估和监测至关重要。由于β定量法操作繁琐且不适用于常规使用，已开发了多种方程来估计LDL-C浓度。然而，在甘油三酯水平升高、低LDL-C或非空腹样本等临床条件下，传统方程的性能可能下降。本研究比较了常规估计公式（Friedewald、Martin-Hopkins和Sampson-Nielsen公式）与机器学习模型在估计血清LDL-C方面的性能。研究使用了一个大型临床实验室数据库，涵盖了广泛的脂质谱特征。结果显示，机器学习模型在广泛的临床条件下均优于传统方程，特别是在甘油三酯升高和低LDL-C水平的情况下。机器学习方法通过利用多种脂质参数之间 Tue, 10 Mar 2026 00:00:00 +0800 血脂 https://doi.org/10.1016/j.plabm.2026.e00524 https://heart.lihaiyang.com/?p=detail&id=169 冠心病（CAD）仍然是全球死亡的主要原因，冠状动脉钙化（CAC）作为动脉粥样硬化的标志物已被广泛认识。虽然CAC评分是评估心血管风险的既定无创工具，但其在有疑似心脏症状的个体中预测冠心病的诊断价值仍需进一步评估。本研究旨在探讨CAC评分在预测有疑似心脏症状个体中冠心病方面的诊断性能。研究纳入了因疑似心脏症状转诊进行非对比计算机断层扫描的患者，所有患者随后接受了有创冠状动脉造影作为参考标准。分析了CAC评分与冠状动脉造影发现的冠心病严重程度之间的相关性。结果显示，CAC评分与冠心病显著相关，CAC评分为零的患者中阻塞性冠心病的患病率极低，而高CAC评分对阻塞性冠心病的阳性预测值较高。CAC评分可 Sat, 07 Mar 2026 00:00:00 +0800 冠心病 https://doi.org/10.1016/j.ahjo.2026.100745 https://heart.lihaiyang.com/?p=detail&id=167 Medical imaging often captures multiple two-dimensional views of three-dimensional anatomic structures, but most artificial intelligence (AI) models analyze two-dimensional data. Here we show that integrating multiple imaging views using a single AI model can improve diagnostic performance. We devel Sun, 01 Mar 2026 00:00:00 +0800 心律失常 https://doi.org/10.1136/bmj.310.6973.170 https://heart.lihaiyang.com/?p=detail&id=168 Decentralized clinical trials (DCTs) move trial activities-such as recruitment, consent, delivery of the intervention, data collection and assessment of outcomes-away from traditional research sites to the homes or communities of patients. This participant-centered approach is accomplished through t Sun, 01 Mar 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1016/j.ahj.2023.02.009 https://heart.lihaiyang.com/?p=detail&id=166 心悸是妊娠期常见的主诉，但动态心脏监测在该人群中的临床意义和诊断价值尚不清楚。本单中心回顾性研究纳入了111名因心悸被转诊至产科心脏病学诊所的妊娠患者，分析了人口统计学和临床特征、超声心动图发现及动态心电事件监测仪数据。主要终点为心律失常检出率，次要终点包括医疗管理变化及母婴结局。在111名患者中，61名（55%）接受了动态心脏监测，其中28名（46%）检出了心律失常。症状与心律异常的相关性在13名（46%）心律失常患者中有记录。7名（25%）检出心律失常的患者启动或继续使用β受体阻滞剂，但与未检出心律失常的患者相比无统计学差异。心律失常检出与患者年龄、孕产次、孕周或既往心律失常或瓣膜病史无显 Thu, 19 Feb 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.ahjo.2026.100740 https://heart.lihaiyang.com/?p=detail&id=165 心电图（ECG）是最常用的诊断工具之一，但其准确解读需要专业的医学知识。本研究开发了ECG-GPT，一种基于人工智能的心电图图像自动解读系统，并进行了多国验证。该系统利用深度学习技术，能够直接从心电图图像中提取诊断信息，识别多种心脏异常。研究使用了来自多个国家和医疗中心的心电图数据进行训练和验证，涵盖了多种心律失常、心肌缺血、传导阻滞等心血管疾病的表现。验证结果显示，ECG-GPT在多项心电图诊断任务中表现优异，其诊断准确率可与经验丰富的心脏病专家媲美，在部分指标上甚至超过了人类判读。该系统具有实时处理能力，可广泛应用于初级医疗保健和资源有限地区，有助于提高心血管疾病的诊断效率和可及性，具有重 Wed, 18 Feb 2026 00:00:00 +0800 心律失常 https://doi.org/10.1093/ehjdh/ztag031 https://heart.lihaiyang.com/?p=detail&id=164 全身炎症可能在慢性肾病的进展和主要心血管事件（MACE）的发展中发挥作用，但这种效应是否独立于传统心血管危险因素尚不清楚。本研究评估了炎症标志物与终末期肾病（ESKD）患者主要心血管事件和死亡之间的关系。研究纳入了接受透析治疗的ESKD患者，测量了多种炎症标志物（包括C反应蛋白、白细胞介素-6等），并进行了长期随访。主要终点为主要心血管事件（定义为心血管死亡、非致死性心肌梗死和非致死性卒中的复合终点）和全因死亡。结果显示，升高的全身炎症标志物与MACE风险和全因死亡率独立相关，即使在校正传统心血管危险因素后仍然显著。炎症标志物升高的患者发生动脉粥样硬化性心血管事件的风险更高。研究结果表明，全身 Tue, 17 Feb 2026 00:00:00 +0800 心衰 https://doi.org/10.1016/j.ekir.2026.106364 https://heart.lihaiyang.com/?p=detail&id=1 The Cardiovascular-Kidney-Metabolic (CKM) syndrome has been recently defined to highlight the interconnections between these organ systems on the natural history of disease and clinical outcomes. To demonstrate associations between CKM interconnection and clinical outcomes in patients with atrial fi Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.04.061 https://heart.lihaiyang.com/?p=detail&id=2 Transthyretin amyloidosis with cardiomyopathy is a progressive, fatal disease characterized by deposition of extracellular misfolded transthyretin (TTR) in the myocardium. Eplontersen is an N-acetylgalactosamine ligand-conjugated antisense oligonucleotide targeting hepatocyte TTR messenger RNA to re Thu, 01 Jan 2026 00:00:00 +0800 心肌病 https://doi.org/10.1161/CIRCHEARTFAILURE.126.014205 https://heart.lihaiyang.com/?p=detail&id=3 Socioeconomic status (SES) is an established risk factor for poor cardiovascular outcomes, with atrial fibrillation (AF) a major contributor to cardiovascular morbidity and mortality. To examine associations between SES, clinical outcomes and access to guideline-directed therapies in patients attend Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.04.052 https://heart.lihaiyang.com/?p=detail&id=4 The combined prevalence of heart failure (HF) with coronary atherosclerosis is frequent and often causally linked. The aim of this review is to elucidate whether lipid lowering drugs (LLDs) are useful in this context. The role of LLDs is interesting in two ways: incidence of HF patients treated with Thu, 01 Jan 2026 00:00:00 +0800 心衰 https://doi.org/10.1093/ehjcvp/pvag033 https://heart.lihaiyang.com/?p=detail&id=5 In stable coronary artery disease, the primary goal of percutaneous coronary intervention (PCI) is symptom relief. Fractional flow reserve (FFR) and nonhyperemic pressure ratios such as resting full-cycle ratio (RFR) are used to guide revascularization. Although these indices correlate with myocardi Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1161/CIRCULATIONAHA.125.078738 https://heart.lihaiyang.com/?p=detail&id=6 Atrial fibrillation (AF) is increasingly common in patients with cancer and is associated with higher risks of stroke, bleeding, and mortality. The growing intersection between cancer and AF presents important challenges for anticoagulation management and cardiovascular risk assessment in cardio-onc Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.04.050 https://heart.lihaiyang.com/?p=detail&id=7 Ultra-processed foods (UPFs) have increasingly displaced traditional diets globally and have become a significant public health concern, particularly in relation to cardiovascular (CV) diseases. UPFs are defined as food products primarily composed of cheap industrial ingredients, additives, and neo- Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1093/eurheartj/ehag226 https://heart.lihaiyang.com/?p=detail&id=8 Preventive imaging for cardiothoracic risk is fragmented across separate pathways. Photon-counting CT (PCCT) may consolidate coronary, aortic-carotid, and pulmonary assessment into a single session while maintaining diagnostic performance and controlling dose. ACTA is an ongoing, general-practitione Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1093/ehjimp/qyag074 https://heart.lihaiyang.com/?p=detail&id=9 Environmental risk factors-air pollution, noise, heat, chemical contamination, and light pollution-are increasingly recognized as key contributors to cardiovascular disease but remain underrepresented in clinical guidelines and public health strategies. This comprehensive review, developed under the Thu, 01 Jan 2026 00:00:00 +0800 心血管预防 https://doi.org/10.1093/eurheartj/ehag270 https://heart.lihaiyang.com/?p=detail&id=10 Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1093/eurheartj/ehag251 https://heart.lihaiyang.com/?p=detail&id=11 The paucity of data to guide selection of specific vasoactive agents in patients with cardiogenic shock (CS) may lead to variability in practice patterns. The level of variability and specific factors that are associated with the use of vasoactive medications and inodilators have not been previously Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1161/CIRCHEARTFAILURE.125.013778 https://heart.lihaiyang.com/?p=detail&id=12 Early detection of risk of heart failure with reduced ejection fraction remains challenging in resource-limited settings due to limited access to echocardiography. Artificial intelligence electrocardiogram (AI-ECG) algorithms have demonstrated promise for identifying left ventricular systolic dysfun Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1001/jamacardio.2026.0908 https://heart.lihaiyang.com/?p=detail&id=13 There is a lack of long-term outcome data supporting the role of nurses in cardiovascular (CV) risk management. The ALLEPRE [ALLiance for sEcondary PREvention after an acute coronary syndrome (ACS)] trial was a pragmatic, randomized, multicentre, interventional trial comparing the efficacy of a nurs Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1093/eurheartj/ehag255 https://heart.lihaiyang.com/?p=detail&id=14 Pediatric patients with heart failure increasingly rely on ventricular assist devices as a bridge to transplantation. The Berlin Heart EXCOR Pediatric is the only durable ventricular assist device specifically approved for infants and small children, but its IKUS driver limits mobility and quality o Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1016/j.jacc.2026.03.080 https://heart.lihaiyang.com/?p=detail&id=15 Although heart disease arises from different etiologies, treatment remains largely one-size-fits-all, leaving many patients without optimal benefit, which highlights the need for cause-directed therapies. Pathogenic variants in RBM20, a cardiac splicing factor, lead to an aggressive form of dilated Thu, 01 Jan 2026 00:00:00 +0800 心衰 https://doi.org/10.1038/s44161-026-00818-2 https://heart.lihaiyang.com/?p=detail&id=16 Artificial intelligence (AI) models can now detect patterns of structural heart diseases (SHDs) from electrocardiograms (ECGs), though scaling them requires the broader use of 1-lead ECGs that are now ubiquitous in wearable and portable devices. However, model development for these devices is limite Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1093/ehjdh/ztag049 https://heart.lihaiyang.com/?p=detail&id=17 Rheumatic heart disease (RHD) remains the most prevalent acquired cardiovascular disease among young adults in developing countries, and there is a critical need for an efficient, affordable, and available screening strategy to detect RHD in these resource-limited areas. The 12-lead electrocardiogra Thu, 01 Jan 2026 00:00:00 +0800 心血管 https://doi.org/10.1093/ehjdh/ztag056