https://heart.lihaiyang.com 心血管文献检索平台 - 最新收录论文 zh-CN https://heart.lihaiyang.com/?p=detail&id=196 For patients undergoing surgical valve procedures with concomitant coronary artery disease, current guidelines recommend that coronary artery bypass grafting (CABG) should be anatomically guided on the basis of stenosis severity, as assessed by coronary angiography. We aimed to test whether a physio Sat, 21 Mar 2026 00:00:00 +0800 冠心病 https://doi.org/10.1016/S0140-6736(25)02418-3 https://heart.lihaiyang.com/?p=detail&id=171 绝经后女性心血管疾病的发病率急剧上升，尤其是冠心病，已成为全球女性面临的主要健康问题。以往的观点认为，雌激素水平下降是绝经后女性风险升高的主要原因。近年来，越来越多的证据表明，绝经后水平急剧升高的促卵泡激素（FSH）可能在此过程中发挥关键作用。本文系统总结了来自临床和动物研究的现有证据，评估了FSH与绝经后女性冠心病风险之间的关系，探索了相互矛盾的证据，并检查了其在动脉粥样硬化发病机制和心脏代谢风险因素调节中的潜在作用。多项研究证实，升高的FSH通过结合肝脏和炎症细胞中的促卵泡激素受体（FSHR），干扰脂质代谢并加剧血管炎症，从而促进冠心病的进展。流行病学证据也支持这一观点。然而，一些临床研究 Fri, 13 Mar 2026 00:00:00 +0800 冠心病 https://doi.org/10.2147/IJWH.S571490 https://heart.lihaiyang.com/?p=detail&id=169 冠心病（CAD）仍然是全球死亡的主要原因，冠状动脉钙化（CAC）作为动脉粥样硬化的标志物已被广泛认识。虽然CAC评分是评估心血管风险的既定无创工具，但其在有疑似心脏症状的个体中预测冠心病的诊断价值仍需进一步评估。本研究旨在探讨CAC评分在预测有疑似心脏症状个体中冠心病方面的诊断性能。研究纳入了因疑似心脏症状转诊进行非对比计算机断层扫描的患者，所有患者随后接受了有创冠状动脉造影作为参考标准。分析了CAC评分与冠状动脉造影发现的冠心病严重程度之间的相关性。结果显示，CAC评分与冠心病显著相关，CAC评分为零的患者中阻塞性冠心病的患病率极低，而高CAC评分对阻塞性冠心病的阳性预测值较高。CAC评分可 Sat, 07 Mar 2026 00:00:00 +0800 冠心病 https://doi.org/10.1016/j.ahjo.2026.100745 https://heart.lihaiyang.com/?p=detail&id=5 In stable coronary artery disease, the primary goal of percutaneous coronary intervention (PCI) is symptom relief. Fractional flow reserve (FFR) and nonhyperemic pressure ratios such as resting full-cycle ratio (RFR) are used to guide revascularization. Although these indices correlate with myocardi Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1161/CIRCULATIONAHA.125.078738 https://heart.lihaiyang.com/?p=detail&id=39 Coronary embolism is an uncommon cause of acute myocardial infarction, often related to atrial fibrillation or valvular heart disease. In such cases, concomitant valvular thrombosis requires additional diagnostic work-up and has major implications for subsequent management. Both conditions may repre Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1093/ehjcr/ytag070 https://heart.lihaiyang.com/?p=detail&id=40 Class III cardiovascular device premarket approval (PMA) studies often fail to fully represent the intended-use population (IUP) owing to low enrollment of racial and ethnic minority subjects and women. The impact of research site selection on this is unknown. In this study, we sought to determine i Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1016/j.jacc.2026.01.088 https://heart.lihaiyang.com/?p=detail&id=46 Endothelial-dependent coronary microvascular and vasomotor dysfunction (CMVD), which requires invasive coronary function test (ICFT) with intracoronary acetylcholine for diagnosis, is the predominant cause of angina in patients with no obstructive coronary artery disease (ANOCA). Oxygenation-sensiti Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1093/ehjci/jeag106 https://heart.lihaiyang.com/?p=detail&id=59 This study aimed to estimate consequences of myocardial infarction (MI) on long-term outcomes and resource needs by comparing outcomes, healthcare resource use, and associated costs between first-time MI patients and matched controls. First-time MI patients from the nationwide SWEDEHEART registry, a Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1093/ehjqcco/qcag071 https://heart.lihaiyang.com/?p=detail&id=61 We aimed to investigate if non-invasive pressure-volume (PV) loop variables by cardiovascular magnetic resonance (CMR) are associated with all-cause mortality or heart failure compared to mean arterial blood pressure (MAP), left ventricular ejection fraction (LVEF), and stroke volume (SV) in patient Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1093/ehjimp/qyag055 https://heart.lihaiyang.com/?p=detail&id=62 Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1093/eurheartj/ehag283 https://heart.lihaiyang.com/?p=detail&id=71 The European Society of Cardiology (ESC) recommends 0/1h-algorithms for triage of patients with suspected myocardial infarction (MI). Recently, cut-offs allowing 3h triage using high-sensitivity cardiac troponin T (hs-cTnT) have been derived, but their prognostic implications remain unclear, and ext Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1093/ehjqcco/qcag062 https://heart.lihaiyang.com/?p=detail&id=77 Unblinded studies have demonstrated superior procedural and clinical outcomes of percutaneous coronary intervention (PCI) in focal compared with diffuse coronary artery disease. However, data from the first placebo-controlled study did not demonstrate a differential impact of disease pattern on symp Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1016/j.jacc.2026.02.5126 https://heart.lihaiyang.com/?p=detail&id=81 While previous studies suggest a cardio-splenic axis involving splenic activation and systemic inflammation, presence and clinical significance of splenic tissue alterations on cardiac magnetic resonance (CMR) in ST-segment-elevation myocardial infarction (STEMI) remain unclear. This study aims to i Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1093/ehjci/jeag104 https://heart.lihaiyang.com/?p=detail&id=91 Percutaneous coronary intervention for coronary chronic total occlusion (CTO PCI) is offered for symptom and quality of life improvement, despite the absence of blinded randomized evidence. The aim of this study was to assess the efficacy of CTO PCI in the first randomized, placebo-controlled trial Thu, 01 Jan 2026 00:00:00 +0800 冠心病 https://doi.org/10.1016/j.jacc.2026.03.027 https://heart.lihaiyang.com/?p=detail&id=162 俯卧位心电图在重症监护和特殊检查环境中经常获取，但其解读受到体位变化的显著影响，导致ST段偏移和T波改变，可能干扰STEMI等心血管疾病的诊断。本研究旨在开发一种将俯卧位心电图转换为标准心电图的方法，以方便医师诊断STEMI和其他心血管疾病。前瞻性采集了标准心电图、心电向量图（VCG）和俯卧位心电图数据，建立基于心电图向量的机器学习模型。研究使用多种机器学习算法进行建模，并通过独立数据集进行验证。结果显示，该模型能够有效校正俯卧位对心电图波形的影响，将俯卧位心电图转换为接近标准体位的等效心电图。转换后的心电图在STEMI诊断准确性方面显著提高。该研究为解决临床实践中俯卧位心电图解读困难提供了新 Wed, 17 Dec 2025 00:00:00 +0800 冠心病 https://doi.org/10.1093/ehjdh/ztaf146 https://heart.lihaiyang.com/?p=detail&id=11011 BACKGROUND: Chronic kidney disease (CKD) significantly increases the risk of coronary artery disease (CAD), but the causal plasma proteins linking these conditions are poorly understood. This study aimed to identify genetically validated plasma biomarkers and therapeutic targets for this cardiorenal Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1080/0886022X.2026.2664285 https://heart.lihaiyang.com/?p=detail&id=32772 OBJECTIVE: To assess serum 25-hydroxyvitamin D [25(OH)D] in relation to indicators of target organ damage in patients with diabetes. METHODS: This analysis included 372 adults with diabetes who underwent serum 25(OH)D testing in the Department of Endocrinology at Jen Ching Memorial Hospital from Jan Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.3389/fendo.2026.1876261 https://heart.lihaiyang.com/?p=detail&id=39172 Coronary heart disease (CHD) is a leading cause of death in women. Observational studies have consistently shown estrogen to help prevent CHD in postmenopausal women. The large randomised controlled Women's Health Initiative (WHI) trial initially did not confirm these observational findings. However Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1080/20533691.2026.2664997 https://heart.lihaiyang.com/?p=detail&id=45572 Coronary artery disease (CAD) is a common cardiovascular disorder strongly associated with glutamine metabolism. This study seeks to identify novel glutamine metabolism-related gene markers in CAD. Based on GEO datasets and glutamine metabolism-related genes, hub genes were pinpointed through WGCNA Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1007/s10863-026-10125-x https://heart.lihaiyang.com/?p=detail&id=32773 BACKGROUND: The adoption of multi-arterial grafting (MAG) remains limited in real-world coronary artery bypass grafting (CABG) practice. This study aimed to identify subsets of patients most likely to benefit clinically from MAG, and to explore potential effect modifiers of its treatment benefit, in Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.3346/jkms.2026.41.e207 https://heart.lihaiyang.com/?p=detail&id=27910 Cadmium is a toxic environmental metal, but its association with prevalent coronary heart disease (CHD) remains uncertain. We examined whether blood cadmium concentrations were associated with prevalent CHD in US adults and explored machine-learning model performance. This cross-sectional study used Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1097/MD.0000000000049554 https://heart.lihaiyang.com/?p=detail&id=32774 BACKGROUND: Among high-bleeding risk (HBR) patients undergoing coronary stenting, abbreviated dual antiplatelet therapy (DAPT) reduces bleeding without ischemic risk trade-off; whether these benefits persist across the entire spectrum of bleeding risk has not been investigated. OBJECTIVES: The aim o Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1016/j.jcin.2026.04.051 https://heart.lihaiyang.com/?p=detail&id=27911 The Dietary Index for Gut Microbiota (DI-GM) is a novel metric assessing diet quality in relation to gut microbial composition. However, its association with all-cause mortality (ACM) in coronary heart disease (CHD) patients remains unexplored. This study aimed to evaluate the association between DI Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1097/MD.0000000000049532 https://heart.lihaiyang.com/?p=detail&id=39175 BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with coronary heart disease (CHD), but convenient and effective biomarkers for identifying CHD risk in patients with MASLD remain limited. The C-reactive protein-triglyceride-glucose index (CTI) refle Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.3389/fendo.2026.1874886 https://heart.lihaiyang.com/?p=detail&id=27912 Ischemic heart disease remains a major contributor to mortality in Malaysia, with non-elective percutaneous coronary intervention (PCI) frequently performed in high-risk acute coronary syndrome (ACS) patients. Using nationwide registry data (2007-2020), we evaluated 29,521 patients and compared seve Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1007/s12265-026-10812-5 https://heart.lihaiyang.com/?p=detail&id=39176 PURPOSE: Patients with familial hypercholesterolemia (FH) are at high risk of coronary artery disease (CAD), and its prediction is of great clinical importance. This study aimed to identify predictors of CAD and construct an effective risk prediction model for Korean patients with FH. MATERIALS AND Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.3349/ymj.2025.0335 https://heart.lihaiyang.com/?p=detail&id=7434 BACKGROUND: The single-point insulin sensitivity estimator (SPISE) is a novel metric used to assess insulin resistance. However, its association with collateral circulation impairment in patients with chronic total occlusion (CTO) remains unclear. This study aims to investigate the relationship betw Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.3389/fendo.2026.1835713 https://heart.lihaiyang.com/?p=detail&id=1548 Atherosclerotic cardiovascular disease (ASCVD), particularly myocardial infarction (MI), is the leading cause of mortality and morbidity worldwide. The pathophysiology of MI involves atherosclerotic plaque rupture with thrombus formation, interrupting myocardial blood supply with subsequent myocardi Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1155/cdr/3961611 https://heart.lihaiyang.com/?p=detail&id=34572 BACKGROUND: Chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD) are major causes of morbidity and mortality, with shared risk factors and often co-occurring. This study investigated the association between both the oral and lower airway microbiome and CHD in healthy control Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1371/journal.pone.0353738 https://heart.lihaiyang.com/?p=detail&id=34573 To investigate the association between cognitive function and postoperative stroke in patients undergoing off-pump coronary artery bypass grafting (CABG). We reviewed patients who underwent cognitive evaluations including Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Pi Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1007/s12265-026-10814-3 https://heart.lihaiyang.com/?p=detail&id=27150 Background: Severe coronary calcification remains a major challenge in percutaneous coronary intervention (PCI), often complicating lesion preparation and stent expansion. Intravascular lithotripsy (IVL) enables controlled plaque modification through acoustic pressure waves, while drug-coated balloo Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.2478/prilozi-2026-0018 https://heart.lihaiyang.com/?p=detail&id=34574 To examine distribution of high-sensitivity cardiac troponin I (hs-cTnI) and myoglobin in patients with suspected coronary microvascular dysfunction (CMD). This study included consecutive patients with chest pain suspected of CMD. Baseline hs-cTnI, myoglobin, and coronary flow reserve (CFR) were ass Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1007/s12265-026-10816-1 https://heart.lihaiyang.com/?p=detail&id=27151 OBJECTIVE: To systematically identify and synthesize the best available evidence on digital health interventions supporting self-management in patients with coronary artery disease (CAD). The aim of this study was to provide evidence-based guidance for healthcare professionals and to inform the deve Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.3389/fpubh.2026.1833261 https://heart.lihaiyang.com/?p=detail&id=34575 BACKGROUND: Growth differentiation factor-15 (GDF-15) is upregulated in coronary artery disease (CAD). The relationship of intensive statin therapy with circulating GDF-15 levels has not been explored yet. In the current secondary analysis of an observational cohort, we investigated whether high-int Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1111/eci.70241 https://heart.lihaiyang.com/?p=detail&id=34576 This study evaluated the impact of human cytomegalovirus (HCMV) infection on vascular inflammation and clinical characteristics in patients with coronary atherosclerotic heart disease (CHD). A total of 180 CHD patients with HCMV infection (research group) and 90 CHD patients without HCMV infection ( Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1111/apm.70229 https://heart.lihaiyang.com/?p=detail&id=52752 PURPOSE: The Seattle Angina Questionnaire (SAQ) is widely used to measure disease-specific health status in coronary artery disease, but its psychometric properties have not been evaluated using multidimensional item response theory (MIRT). We evaluated the SAQ's dimensional structure, measurement p Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1007/s11136-026-04368-9 https://heart.lihaiyang.com/?p=detail&id=34577 BACKGROUND: Percutaneous coronary interventions (PCI) for chronic total occlusions (CTO) remain challenging procedures with controversial long-term clinical benefits. METHODS: We conducted an observational monocentric study including consecutive patients who underwent PCI for CTO by experienced oper Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1002/clc.70414 https://heart.lihaiyang.com/?p=detail&id=23570 BACKGROUND: The translocation into the systemic circulation of proinflammatory bacterial components such as lipopolysaccharide (LPS) has been linked to cardiovascular disease (CVD). OBJECTIVES: We aimed to evaluate the association between baseline postprandial endotoxemia and the risk of suffering m Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1016/j.ajcnut.2026.101323 https://heart.lihaiyang.com/?p=detail&id=34578 PURPOSE: Patients on hemodialysis (HD) undergoing coronary artery bypass grafting (CABG) face a high risk of perioperative complications, and the optimal timing of perioperative HD remains unclear. We evaluated the safety and feasibility of a standardized HD protocol in patients undergoing off-pump Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.5761/atcs.oa.25-00220 https://heart.lihaiyang.com/?p=detail&id=34579 BACKGROUND: Patients with multivessel coronary artery disease often receive 12 months of dual antiplatelet therapy (DAPT) after stenting to reduce the risk of ischemic events. Whether extending DAPT beyond 12 months in event-free patients with multivessel disease provides a benefit is uncertain. MET Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1056/NEJMoa2517588 https://heart.lihaiyang.com/?p=detail&id=36372 BACKGROUND: Drug-coated balloons (DCBs) represent a "leave-nothing-behind" strategy in percutaneous coronary intervention (PCI), particularly for small vessel disease and in-stent restenosis. However, long-term comparative real-world data between paclitaxel- and sirolimus-coated balloons remain limi Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1177/17539447261463654 https://heart.lihaiyang.com/?p=detail&id=42772 Coronary artery bypass grafting (CABG) remains one of the most durable treatments for obstructive coronary artery disease (CAD), particularly in anatomically complex multivessel disease, diabetes, left main disease and ischaemic cardiomyopathy. During the last three decades, the conventional operati Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1007/s11701-026-03737-3 https://heart.lihaiyang.com/?p=detail&id=38172 BACKGROUND: The relationship between sex differences and clinical outcomes following coronary artery bypass grafting (CABG) has been highlighted in several studies. However, these studies were mostly based on single- or multi-center data, and only a few meta-analyses examined long-term outcomes. To Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.3346/jkms.2026.41.e161 https://heart.lihaiyang.com/?p=detail&id=3361 BACKGROUND: The diagnostic and prognostic roles of cardiovascular biomarkers in chronic coronary syndrome remain unclear. METHODS: Patients undergoing coronary angiography for suspected chronic coronary syndrome were prospectively enrolled (n=2251; median follow-up 12.6 years). Obstructive coronary Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1161/JAHA.125.048737 https://heart.lihaiyang.com/?p=detail&id=3362 BACKGROUND: Drug-coated balloons (DCB) are frequently used during percutaneous coronary intervention. Despite this there are limited data from studies comparing different types of DCB, particularly for a paclitaxel-coated balloon (PCB) using urea as the excipient. This study aimed to assess the clin Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1161/JAHA.125.045621 https://heart.lihaiyang.com/?p=detail&id=11810 OBJECTIVE: This study aimed to explore the importance of the triglyceride-glucose (TyG) index and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio in predicting the risk of coronary heart disease (CHD) in elderly postmenopausal women. METHODS: This was a retrospective cohort stud Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.7717/peerj.21423 https://heart.lihaiyang.com/?p=detail&id=548 BACKGROUND: Peripheral artery disease (PAD) is prevalent and frequently co-occurs with type 2 diabetes (T2D) and coronary artery disease (CAD). Although shared genetic factors-pleiotropy-may contribute to these comorbidities, few studies have examined pleiotropy at the transcriptomic and proteomic l Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.1093/hmg/ddag035 https://heart.lihaiyang.com/?p=detail&id=33572 Colchicine has emerged as a promising anti-inflammatory option for secondary prevention in coronary artery disease, but its role in routine practice remains uncertain. Evidence from randomised trials suggests a more consistent benefit in chronic coronary syndromes and selected post-myocardial infarc Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.55563/clinexprheumatol/hcz3hu https://heart.lihaiyang.com/?p=detail&id=549 Chronic total occlusions (CTO) occur in 15-30% of coronary angiogram, yet this challenging lesion subset represents less than 10% of percutaneous coronary interventions (PCI). [cite: 69] Tunisian data are lacking. This study analyses a real-life Tunisian CTO-PCI immediate and long-term results. [cit Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.62438/tunismed.v104i02.6457 https://heart.lihaiyang.com/?p=detail&id=33573 Exposure to hydrocarbons, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), represents an escalating public health concern. These compounds induce systemic inflammation, oxidative stress, and endothelial dysfunction, driving cardiovascular disease (CVD) pathoge Mon, 30 Nov -001 00:00:00 +0805 冠心病 https://doi.org/10.2147/VHRM.S607849