https://heart.lihaiyang.com 心血管文献检索平台 - 最新收录论文 zh-CN https://heart.lihaiyang.com/?p=detail&id=182 胸主动脉夹层是一种高发病率和高死亡率的急性血管疾病。内皮细胞对维持血管稳态至关重要，但内皮-间充质转化在胸主动脉夹层中的作用尚不明确。PDK4（丙酮酸脱氢酶激酶4）作为这一病理细胞命运转换驱动因素的功能也未被阐明。本研究整合了人体主动脉标本和β-氨基丙腈诱导小鼠模型的转录组分析和免疫荧光分析，通过RNA测序和染色质免疫沉淀测定鉴定PDK4为内皮-间充质转化信号的关键下游效应因子。研究发现，转录因子SNAI1直接结合PDK4启动子激活其表达，过量的PDK4通过乳酸积累促进内皮-间充质转化，建立了PDK4-EndoMT正反馈环路。体内实验中，内皮特异性Pdk4过表达可自发引起主动脉夹层和破裂，而内 Thu, 19 Mar 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/ATVBAHA.125.324031 https://heart.lihaiyang.com/?p=detail&id=183 主动脉夹层是一种危及生命的疾病，涉及血管平滑肌细胞从收缩表型向合成表型的病理性转换。尽管运动具有广泛的心血管益处，但其在主动脉夹层发病机制中的作用尚不清楚。本研究旨在确定运动是否通过调节血管平滑肌细胞表型来减轻主动脉夹层，并阐明其潜在的分子机制。在人体主动脉夹层病变组织中，收缩型血管平滑肌细胞标志物（MYH11、CNN1和α-SMA）显著下调，而合成标志物骨桥蛋白上调。在β-氨基丙腈诱导的主动脉夹层小鼠模型中，运动提高了生存率，减少了主动脉扩张和夹层发生率，并维持了血管平滑肌细胞的收缩表型。RNA测序分析将PDE5A鉴定为关键的应答运动基因。血管平滑肌细胞特异性过表达PDE5A可减轻夹层进展， Thu, 19 Mar 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/ATVBAHA.125.324293 https://heart.lihaiyang.com/?p=detail&id=7 Ultra-processed foods (UPFs) have increasingly displaced traditional diets globally and have become a significant public health concern, particularly in relation to cardiovascular (CV) diseases. UPFs are defined as food products primarily composed of cheap industrial ingredients, additives, and neo- Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1093/eurheartj/ehag226 https://heart.lihaiyang.com/?p=detail&id=22 Vascular aging is a central determinant of healthy life span, not only influencing the susceptibility to cardiovascular diseases but also shaping the risk of systemic decline across multiple organs. It is driven by a variety of age-related factors, including cellular senescence, chronic inflammation Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/CIRCULATIONAHA.125.075567 https://heart.lihaiyang.com/?p=detail&id=45 Over the past decade, colchicine has re-emerged as a promising therapeutic candidate for atherosclerotic cardiovascular disease. Here we review evidence from large randomized controlled trials together with advances in mechanistic research that have clarified how colchicine modulates vascular inflam Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1038/s44161-026-00807-5 https://heart.lihaiyang.com/?p=detail&id=57 An increased numbers of women initiate motherhood at an advanced age. Advanced maternal age (AMA) at first delivery poses unique clinical challenges; however, limited literature exists regarding potential long-term implications. We investigated the association between AMA at first delivery on matern Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1093/ehjqcco/qcag076 https://heart.lihaiyang.com/?p=detail&id=65 The pyruvate dehydrogenase kinase (PDK)/pyruvate dehydrogenase (PDH) axis plays a pivotal role in regulating cellular energy metabolism, controlling the flux between the tricarboxylic acid cycle and oxidative phosphorylation. Traditionally viewed through a metabolic lens, this axis is now emerging a Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1093/cvr/cvag088 https://heart.lihaiyang.com/?p=detail&id=96 Cardiovascular disease (CVD) remains the leading cause of global mortality, prompting urgent efforts to explore novel therapeutic approaches. The remarkable success of mRNA technology brings new possibilities for CVD treatment, with numerous preclinical studies establishing proof-of-concept, and sev Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1038/s44161-026-00804-8 https://heart.lihaiyang.com/?p=detail&id=97 Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1016/j.jchf.2026.102990 https://heart.lihaiyang.com/?p=detail&id=107 Mitochondria-derived vesicles (MDVs) and mitochondrial extracellular vesicles (mitoEVs) represent 2 related extensions of mitochondrial dynamics that link organelle maintenance to communication within and between cells. MDVs are small vesicles that bud directly from mitochondria, selectively packagi Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/CIRCRESAHA.125.327357 https://heart.lihaiyang.com/?p=detail&id=108 Intercellular mitochondrial transfer has emerged as a fundamental mechanism of tissue adaptation and repair in the cardiovascular system, with major implications for cardiovascular, neurological, metabolic, and inflammatory diseases. Once thought to be static, mitochondria are now recognized as mobi Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/CIRCRESAHA.125.326984 https://heart.lihaiyang.com/?p=detail&id=110 Mitochondria are important organelles for metabolic homeostasis, cell fate, and survival. Emerging evidence suggests that mitochondria are not confined to the cells. Intercellular mitochondrial transfer (IMT) is increasingly recognized between a variety of cells, including major cell types in the ca Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/CIRCRESAHA.125.326986 https://heart.lihaiyang.com/?p=detail&id=111 Mitochondria are essential organelles that transform the energy contained in metabolic substrates into ATP while supporting numerous cellular processes. Traditionally regarded as strictly intracellular, growing evidence now demonstrates that mitochondria and mitochondria-derived components can also Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1161/CIRCRESAHA.125.326988 https://heart.lihaiyang.com/?p=detail&id=114 Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1001/jamacardio.2026.0412 https://heart.lihaiyang.com/?p=detail&id=115 Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1001/jamacardio.2026.0409 https://heart.lihaiyang.com/?p=detail&id=120 Thyroid hormones play an important role in regulating the cardiovascular system. Thyroid dysfunction, which encompasses hypothyroidism and hyperthyroidism, is relatively common and has been linked to a range of cardiovascular manifestations, including dyslipidaemia, abnormal blood pressure regulatio Thu, 01 Jan 2026 00:00:00 +0800 动脉粥样硬化 https://doi.org/10.1093/eurheartj/ehag248 https://heart.lihaiyang.com/?p=detail&id=43012 Ferroptosis is a regulated form of cell death in which disturbed iron metabolism, accumulation of peroxidized membrane lipids, and insufficient glutathione peroxidase 4 (GPX4) activity converge to injure vascular cells. In atherosclerosis, its effects are highly dependent on cellular context rather Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1002/cbf.70264 https://heart.lihaiyang.com/?p=detail&id=43013 BACKGROUND: Psoriasis (PSO) and atherosclerosis (AS) are chronic inflammatory diseases that frequently coexist, with each condition exacerbating the other. However, the underlying mechanisms remain poorly understood, partly due to the lack of a suitable animal model that recapitulates this bidirecti Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1155/mi/1377824 https://heart.lihaiyang.com/?p=detail&id=32012 Follistatin (FST) binds to and neutralizes members of the transforming growth factor-beta (TGF-β) superfamily, thereby regulating diverse physiological processes, including regulation of skeletal muscle, adipose, and bone homeostasis. FST also promotes adipose browning and enhances energy metabolism Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.3390/cells15131205 https://heart.lihaiyang.com/?p=detail&id=51213 Atherosclerosis, which leads to cardiovascular disease (CVD), can progress without any symptoms. To prevent CVD, it is important to detect atherosclerotic lesions early and assess their severity. Atherosclerosis evaluation for primary prevention is a preferable non-invasive diagnostic tool. In this Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.18999/nagjms.88.2.326 https://heart.lihaiyang.com/?p=detail&id=51214 BACKGROUND: Atherosclerosis (AS), which causes chronic inflammation, aberrant lipid metabolism and vascular endothelial damage, is the main cause of cardiovascular disease. The Ce-Bai-Si-Wei decoction (CSD) may reduce AS, although its molecular mechanisms are unknown. This study investigates core mo Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1155/jdr/9699723 https://heart.lihaiyang.com/?p=detail&id=51215 Chronic limb-threatening ischemia is the most advanced stage of peripheral arterial disease and typically requires revascularization to prevent limb-loss. The choice of open surgical bypass versus endovascular therapy should be individualized based on patients' anatomy, operative risk, and conduit a Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1016/j.yasu.2026.03.003 https://heart.lihaiyang.com/?p=detail&id=51216 OBJECTIVE: To estimate the magnitude of reduction in major adverse cardiovascular events (MACE) that would be observed in clinical practice from adding tirzepatide to standard of care treatment. DESIGN: Population based cohort study, using a design, data, and analytical approach previously benchmark Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1136/bmj-2026-100011 https://heart.lihaiyang.com/?p=detail&id=4369 OBJECTIVES: Atherosclerosis (AS) is a chronic inflammatory vascular disorder driven by endothelial dysfunction, oxidative stress, lipid dysregulation, mitochondrial injury, and maladaptive immune activation. Metformin, the first-line therapy for type 2 diabetes, has vasculoprotective effects beyond Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1093/jpp/rgag056 https://heart.lihaiyang.com/?p=detail&id=33812 Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality in patients with insulin resistance, and new therapies are urgently needed. We previously developed an orally administered formulation of 2,4-dinitrophenol, here termed controlled-release mitochondrial Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1126/scitranslmed.adv1815 https://heart.lihaiyang.com/?p=detail&id=46613 This study aimed to investigate the relationships between visit-to-visit variability in HbA1c and fasting plasma glucose (FPG) and atherosclerotic markers in persons with type 2 diabetes mellitus (T2DM), employing epidemiological analyses and Mendelian randomization (MR) techniques. Between January Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1097/MD.0000000000049991 https://heart.lihaiyang.com/?p=detail&id=8470 Oxidized low-density lipoprotein (oxLDL) is a central driver of inflammatory responses in atherosclerosis and triggers multiple forms of regulated cell death beyond classical apoptosis. Ferroptosis, characterized by iron-dependent lipid peroxidation (LPO), and pyroptosis, mediated by inflammasome-ac Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.3389/fimmu.2026.1831457 https://heart.lihaiyang.com/?p=detail&id=26390 Type 2 diabetes mellitus and peripheral artery disease are pathophysiologically interlinked through shared mechanisms such as chronic inflammation and endothelial dysfunction, highlighting the imperative to identify common biomarkers for enhancing early detection and risk stratification. A review of Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1002/dmrr.70200 https://heart.lihaiyang.com/?p=detail&id=33814 The liver plays a major role in regulating the metabolic fate of lipids and facilitates lipid secretion to peripheral organs in the form of VLDLs or lipid storage in lipid droplets (LDs). Hepatic regulation of excess lipids profoundly influences the development of atherosclerosis; thus, uncovering t Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1172/JCI208521 https://heart.lihaiyang.com/?p=detail&id=8471 Atherosclerotic vascular disease is the major cause of mortality in type 2 diabetes. This study sought to examine the effects of different receptor for advanced glycation end-products (RAGE)-targeted interventions in diabetic atherosclerosis. A diabetic atherosclerosis model was constructed in ApoE- Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.4149/gpb_2025041 https://heart.lihaiyang.com/?p=detail&id=8473 In recent years, the study of interleukins (ILs), crucial cytokines involved in inflammation, has garnered significant attention within coronary artery disease including atherosclerosis. This review provides a detailed overview of anti-inflammatory ILs, elucidating their functions within the pathoge Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.3390/ijms27115030 https://heart.lihaiyang.com/?p=detail&id=33817 Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants increasingly associated with cardiovascular disease. Identifying early manifestations of vascular aging before the onset of overt disease is essential for improving cardiovascular risk stratification and prevention. Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.3390/ijms27136064 https://heart.lihaiyang.com/?p=detail&id=33818 This single-center prospective observational study evaluated peri-procedural changes in circulating markers of endothelial glycocalyx injury in patients with chronic limb-threatening ischemia undergoing lower extremity endovascular treatment. Fifty patients (mean age 72.2 years; 56% with diabetes me Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.3390/ijms27136011 https://heart.lihaiyang.com/?p=detail&id=8475 BACKGROUND: Evidence regarding the relationships between atherogenic index of plasma (AIP)-related indices and carotid atherosclerosis (CA) is limited. METHODS: A total of 59123 participants from the China Stroke High-risk Population Screening and Intervention Program (CSHPSIP) in Hubei Province, Ch Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1080/07853890.2026.2687227 https://heart.lihaiyang.com/?p=detail&id=8476 BACKGROUND: Peripheral Arterial Disease (PAD) is a prevalent but underdiagnosed pathology. Soluble CD146 (sCD146) was described as a marker of endothelial dysfunction and vascular congestion. OBJECTIVE: We hypothesize that sCD146 may represent a novel biomarker of PAD. Our objective was to evaluate Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1007/s10456-026-10064-6 https://heart.lihaiyang.com/?p=detail&id=42012 OBJECTIVES: Atherosclerosis significantly contributes to global cardiovascular mortality. Macrophage polarization and foam cell formation via oxidized low-density lipoprotein uptake are key drivers of plaque progression and instability. Targeting these processes may offer a promising therapeutic app Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1093/jpp/rgag079 https://heart.lihaiyang.com/?p=detail&id=48412 This study integrated network pharmacology, computational simulation, spatial transcriptomics, and animal experiments to systematically reveal the multi-level mechanism of the traditional Chinese medicine compound Zuopi Pills in treating atherosclerosis(AS) by inhibiting ferroptosis via the acyl-CoA Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.19540/j.cnki.cjcmm.20260305.705 https://heart.lihaiyang.com/?p=detail&id=33821 Endothelial dysfunction is an early event in the development of cardiovascular diseases and is characterized by impaired barrier function, inflammatory activation of endothelial cells (ECs), and alterations in lipid metabolism. In addition to typical (mononuclear) endothelial cells (TECs), multinucl Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.3390/ijms27135728 https://heart.lihaiyang.com/?p=detail&id=42013 PURPOSE OF REVIEW: This article reviews the existing literature on non-LDL biomarkers in atherosclerotic cardiovascular disease (ACSVD), atherogenesis, and ischemic stroke risk, including a discussion of potential future applications for secondary prevention of stroke. RECENT FINDINGS: Although foun Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1007/s11883-026-01449-5 https://heart.lihaiyang.com/?p=detail&id=48413 This study systematically investigated the mechanism of Scutellariae Radix against atherosclerosis(AS) through the integrated application of network pharmacology, molecular docking, and animal experiments. A total of 34 active ingredients of Scutellariae Radix were screened from the TCMSP database, Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.19540/j.cnki.cjcmm.20260228.501 https://heart.lihaiyang.com/?p=detail&id=48414 This paper investigated the effects and mechanisms of Zhizi Dahuang Decoction(ZZDHT) in treating atherosclerosis(AS) through a comprehensive approach combining network pharmacology, molecular docking, and in vivo experiments. Active components and target sites of ZZDHT were identified and screened u Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.19540/j.cnki.cjcmm.20260302.801 https://heart.lihaiyang.com/?p=detail&id=8479 Carotid-femoral pulse-wave velocity (cfPWV) is a marker of central arterial stiffness and an established predictor of cardiovascular risk in hypertension. Although elevated lipoprotein(a) [Lp(a)] concentrations and peripheral arterial disease (PAD) are associated with atherosclerotic cardiovascular Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1111/jch.70309 https://heart.lihaiyang.com/?p=detail&id=8481 OBJECTIVE: Low inflammation associated with fish intake may reflect not only the amount of fish consumed but also its nutrient composition and related lifestyle factors. This study investigated the relationship between fish intake, estimated n-3 polyunsaturated fatty acid (n-3 PUFA) intake, lifestyl Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1016/j.plefa.2026.102750 https://heart.lihaiyang.com/?p=detail&id=15650 BACKGROUND: Atherosclerosis (AS) is the leading cause of cardiovascular death worldwide. Macrophage ferroptosis is implicated in AS progression. The precise mechanism by which mixed lineage kinase 3 (MAP3K11, MLK3) regulates macrophage ferroptosis in atherosclerosis is poorly understood. METHODS: Fr Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1007/s00011-026-02292-9 https://heart.lihaiyang.com/?p=detail&id=24610 OBJECTIVES: Cardiovascular disease is the most common extrahepatic complication and leading cause of death in metabolic dysfunction‑associated fatty liver disease (MAFLD). However, early metabolic biomarkers for subclinical atherosclerosis (SA) in MAFLD patients remain unclear. This study used untar Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.11817/j.issn.1672-7347.2026.260024 https://heart.lihaiyang.com/?p=detail&id=32812 BACKGROUND: Circulating monocyte trans-endothelial migration is critical for vascular diseases. The monocyte surface proteins, i.e., integrins and membrane receptors are central in this process. Previous studies demonstrate that ablation of the mitochondrial arginase-2 (ARG2) reduces monocyte/macrop Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.1186/s12929-026-01278-3 https://heart.lihaiyang.com/?p=detail&id=52012 Triggering receptor expressed on myeloid cells 2 (TREM2) is a key transmembrane immune receptor that is specifically highly expressed in myeloid cells, particularly macrophages, within atherosclerosis (AS) plaques. Advances in single-cell sequencing technology have clearly defined TREM2-high macroph Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.11817/j.issn.1672-7347.2026.260045 https://heart.lihaiyang.com/?p=detail&id=52013 Revascularization remains the cornerstone of treatment for CLTI. Conservative treatment represents an underexposed yet potentially appropriate alternative for selected elderly and frail patients. This population is characterized by high mortality rates, substantial perioperative risks, prolonged hos Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://heart.lihaiyang.com/?p=detail&id=52013 https://heart.lihaiyang.com/?p=detail&id=27950 OBJECTIVE: Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by dysregulated lipid homeostasis and plaque formation. Consequently, there is an ongoing need for therapies with high efficacy and low toxicity. Thus, this study aimed to investigate the effects of guggulsteron Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.31083/Pharmazie52690 https://heart.lihaiyang.com/?p=detail&id=39214 INTRODUCTION: Microvascular disease is a common complication of type 2 diabetes mellitus (T2DM). As a typical microvascular complication, diabetic kidney disease (DKD) interacts with peripheral atherosclerosis (AS) and significantly increases the risk of adverse cardiovascular events. OBJECTIVES: To Mon, 30 Nov -001 00:00:00 +0805 动脉粥样硬化 https://doi.org/10.3389/fendo.2026.1870637