https://heart.lihaiyang.com 心血管文献检索平台 - 最新收录论文 zh-CN https://heart.lihaiyang.com/?p=detail&id=180 房性早搏是最常见的心律失常之一，频繁的房性早搏可增加房颤、卒中和心力衰竭的风险，但目前尚无批准的特异性治疗药物。本研究为一项II期随机临床试验，旨在评估美金刚（一种NMDA受体拮抗剂）治疗房性早搏的疗效和安全性。美金刚通过阻断NMDA受体介导的过度交感神经激活，理论上可以减少房性异位激动。研究纳入了频繁房性早搏患者，随机分配至美金刚治疗组和安慰剂组，通过24小时动态心电图评估房性早搏负荷变化。主要终点为治疗8周后房性早搏减少的百分比。该研究为房性早搏的药物治疗提供了新的思路，如果证实有效，美金刚可能成为首个专门针对房性早搏的治疗药物，具有重要的临床意义。 Thu, 19 Mar 2026 00:00:00 +0800 心律失常 https://doi.org/10.1161/CIRCULATIONAHA.125.079023 https://heart.lihaiyang.com/?p=detail&id=167 Medical imaging often captures multiple two-dimensional views of three-dimensional anatomic structures, but most artificial intelligence (AI) models analyze two-dimensional data. Here we show that integrating multiple imaging views using a single AI model can improve diagnostic performance. We devel Sun, 01 Mar 2026 00:00:00 +0800 心律失常 https://doi.org/10.1136/bmj.310.6973.170 https://heart.lihaiyang.com/?p=detail&id=166 心悸是妊娠期常见的主诉，但动态心脏监测在该人群中的临床意义和诊断价值尚不清楚。本单中心回顾性研究纳入了111名因心悸被转诊至产科心脏病学诊所的妊娠患者，分析了人口统计学和临床特征、超声心动图发现及动态心电事件监测仪数据。主要终点为心律失常检出率，次要终点包括医疗管理变化及母婴结局。在111名患者中，61名（55%）接受了动态心脏监测，其中28名（46%）检出了心律失常。症状与心律异常的相关性在13名（46%）心律失常患者中有记录。7名（25%）检出心律失常的患者启动或继续使用β受体阻滞剂，但与未检出心律失常的患者相比无统计学差异。心律失常检出与患者年龄、孕产次、孕周或既往心律失常或瓣膜病史无显 Thu, 19 Feb 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.ahjo.2026.100740 https://heart.lihaiyang.com/?p=detail&id=165 心电图（ECG）是最常用的诊断工具之一，但其准确解读需要专业的医学知识。本研究开发了ECG-GPT，一种基于人工智能的心电图图像自动解读系统，并进行了多国验证。该系统利用深度学习技术，能够直接从心电图图像中提取诊断信息，识别多种心脏异常。研究使用了来自多个国家和医疗中心的心电图数据进行训练和验证，涵盖了多种心律失常、心肌缺血、传导阻滞等心血管疾病的表现。验证结果显示，ECG-GPT在多项心电图诊断任务中表现优异，其诊断准确率可与经验丰富的心脏病专家媲美，在部分指标上甚至超过了人类判读。该系统具有实时处理能力，可广泛应用于初级医疗保健和资源有限地区，有助于提高心血管疾病的诊断效率和可及性，具有重 Wed, 18 Feb 2026 00:00:00 +0800 心律失常 https://doi.org/10.1093/ehjdh/ztag031 https://heart.lihaiyang.com/?p=detail&id=1 The Cardiovascular-Kidney-Metabolic (CKM) syndrome has been recently defined to highlight the interconnections between these organ systems on the natural history of disease and clinical outcomes. To demonstrate associations between CKM interconnection and clinical outcomes in patients with atrial fi Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.04.061 https://heart.lihaiyang.com/?p=detail&id=3 Socioeconomic status (SES) is an established risk factor for poor cardiovascular outcomes, with atrial fibrillation (AF) a major contributor to cardiovascular morbidity and mortality. To examine associations between SES, clinical outcomes and access to guideline-directed therapies in patients attend Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.04.052 https://heart.lihaiyang.com/?p=detail&id=6 Atrial fibrillation (AF) is increasingly common in patients with cancer and is associated with higher risks of stroke, bleeding, and mortality. The growing intersection between cancer and AF presents important challenges for anticoagulation management and cardiovascular risk assessment in cardio-onc Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.04.050 https://heart.lihaiyang.com/?p=detail&id=53 Patients with acute myocardial infarction (MI) and atrial fibrillation (AF) present challenges in antithrombotic treatment. Effects of newer treatment strategies on outcomes remain uncertain. We assessed implementation of antithrombotic treatment and occurrence of cardiovascular (CV) events and majo Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1093/ehjcvp/pvag027 https://heart.lihaiyang.com/?p=detail&id=67 Epicardial catheter ablation is an established treatment for ventricular tachycardia (VT) in patients with structural heart disease (SHD); however, VT recurrence remains frequent, particularly in advanced cardiomyopathy. To identify clinical and electrophysiological determinants of VT recurrence fol Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.04.026 https://heart.lihaiyang.com/?p=detail&id=68 Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1161/CIRCEP.125.014619 https://heart.lihaiyang.com/?p=detail&id=83 Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1161/CIRCULATIONAHA.125.077870 https://heart.lihaiyang.com/?p=detail&id=84 Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1161/CIRCULATIONAHA.126.079913 https://heart.lihaiyang.com/?p=detail&id=90 Atrial fibrillation (AF) is the most common arrhythmia and is associated with high morbidity and mortality, particularly in the aging population. Current treatment and prevention strategies remain suboptimal, highlighting the urgent need to better understand the mechanisms underlying aging-associate Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1161/CIRCULATIONAHA.125.076147 https://heart.lihaiyang.com/?p=detail&id=103 Cardiac arrhythmia is increasingly encountered in patients with cancer, not only as a result of shared risk factors but also as a direct consequence of malignancy and its therapies. This evolving overlap has positioned arrhythmia management as a key component of cardio-oncology practice. This review Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.03.1944 https://heart.lihaiyang.com/?p=detail&id=104 Patients with atrial fibrillation (AF) commonly present with other comorbidities, including metabolic, kidney, or cardiovascular risk factors, which have a complex interplay leading to increased mortality and morbidity. The purpose of this study was to evaluate the association between cardiovascular Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.02.038 https://heart.lihaiyang.com/?p=detail&id=105 Acute myocarditis (AM) complicated by ventricular arrhythmias (VA) carries an uncertain risk of VA recurrence after discharge. Predictors are poorly defined, complicating risk stratification and implantable cardioverter defibrillator (ICD) decision-making. To assess recurrence rates and identify pre Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1016/j.hrthm.2026.03.1952 https://heart.lihaiyang.com/?p=detail&id=112 Serum neurofilament light chain (sNfL) is a blood-based biomarker initially investigated for neuronal injury and is elevated in patients with atrial fibrillation (AF). Whether sNfL is associated with other adverse outcomes in this population is less well studied. To determine the association between Thu, 01 Jan 2026 00:00:00 +0800 心律失常 https://doi.org/10.1001/jamacardio.2026.0922 https://heart.lihaiyang.com/?p=detail&id=33536 Cardiovascular disease and cancer remain the leading causes of death worldwide. Although numerous cancer therapies have improved survival rates, they also increase the risk of cardiomyopathy, heart failure, and arrhythmias. These cardiovascular complications can limit treatment options and adversely Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.3390/ijms27135663 https://heart.lihaiyang.com/?p=detail&id=22530 OBJECTIVE: Grounded in an integrated fear-avoidance and cognitive-behavioural framework, this study aimed to examine the independent and sequential mediating roles of exercise sensitivity and kinesiophobia in the relationship between symptom burden and physical activity in patients with atrial fibri Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1371/journal.pone.0352864 https://heart.lihaiyang.com/?p=detail&id=8196 BACKGROUND: Artificial intelligence (AI) tools are increasingly being explored for medical applications; however, their effectiveness in emergency electrocardiogram (ECG) interpretation is under-investigated. In this pilot study we aimed to evaluate the diagnostic performance of AI interpretation of Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.5811/westjem.48718 https://heart.lihaiyang.com/?p=detail&id=28932 BACKGROUND: Doxorubicin (DOX), a widely used chemotherapeutic agent for cancer patients, is associated with a significant risk of inducing atrial fibrillation (AF), a serious cardiac complication that impairs patient prognosis. However, the specific molecular and cellular mechanisms linking DOX card Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1371/journal.pone.0353143 https://heart.lihaiyang.com/?p=detail&id=35332 Anticoagulants are crucial for both the immediate and ongoing management of thromboembolic disorders, including atrial fibrillation and venous thromboembolism, and for patients with mechanical heart valves. However, their management during the periprocedural period requires carefully balancing throm Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1371/journal.pone.0353786 https://heart.lihaiyang.com/?p=detail&id=35333 BACKGROUND: Home ECG can detect atrial fibrillation (AF), but patients' hospital visit behavior after "possible AF" alerts remains uncertain. We assessed the rates, timing, and correlates of hospital visits following "possible AF" alerts in older adults with hypertension. METHODS AND FINDINGS: In a Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1371/journal.pone.0353867 https://heart.lihaiyang.com/?p=detail&id=13576 Objectives. Data quality is a prerequisite for the use of registries. National Registry for Ablation and Electrophysiology in Norway (AblaNor) is a nationwide medical quality register of Norwegian patients undergoing electrophysiology (EP) examination and ablation. The aim of this study is to assess Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1080/14017431.2026.2690760 https://heart.lihaiyang.com/?p=detail&id=35337 Thyrotoxic periodic paralysis (TPP) is a rare variant presentation associated with thyrotoxicosis. It is characterised by acute hypokalaemic paralysis due to intracellular potassium shift. We describe a man in his early 30s who presented with sudden-onset flaccid quadriparesis and transient self-rev Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1136/bcr-2025-267568 https://heart.lihaiyang.com/?p=detail&id=17930 Clinical decision-making increasingly relies on deep neural networks (DNNs), yet their deployment in practice requires transparent and interpretable predictions. Explainable artificial intelligence (xAI) methods can identify input regions relevant to a model's decision, but their clinical interpreta Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1038/s41598-026-59076-8 https://heart.lihaiyang.com/?p=detail&id=17931 BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease that is associated with cardiovascular comorbidities, particularly with an increased risk of arrhythmias. Despite the evidence, a structured population-based risk stratification that relates ECG parameters to clinical c Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1136/rmdopen-2026-007006 https://heart.lihaiyang.com/?p=detail&id=17932 OBJECTIVES: While kinesiophobia is a recognised phenomenon in global cardiovascular rehabilitation, its prevalence and characteristics remain unexplored in the specific and growing population of patients hospitalised with atrial fibrillation and heart failure (AFHF). This study aims to investigate t Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.5830/CVJA-2026-009 https://heart.lihaiyang.com/?p=detail&id=30732 New-onset postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery, especially coronary artery bypass grafting (CABG), affecting up to 40% of patients, and is associated with increased risks of thromboembolic events and prolonged hospital stays. Traditionally, warf Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1097/MD.0000000000049695 https://heart.lihaiyang.com/?p=detail&id=17933 OBJECTIVE: The minimised extracorporeal circulation (MiECC) system is an alternative to the classical extracorporeal circulation (ECC) system in coronary artery bypass grafting (CABG) surgery. Some publications reported that there are few studies on the relationship between this application and the Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.5830/CVJA-2026-011 https://heart.lihaiyang.com/?p=detail&id=30734 BACKGROUND AND AIM: Atrial fibrillation (AF) is a substantial public health disorder associated with heightened morbidity and mortality. Pulmonary vein isolation (PVI) has limited efficacy in persistent AF (PAF), indicating additional strategies such as left atrial appendage electrical isolation (LA Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1186/s12872-026-05607-0 https://heart.lihaiyang.com/?p=detail&id=5391 IMPORTANCE: The prevalence of atrial fibrillation (AF) and atrial flutter (AFL) among pregnant patients has increased over time, with AF now being the most common sustained cardiac arrhythmia in pregnancy. Management of AF/AFL in pregnancy presents unique clinical challenges, with careful considerat Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1097/OGX.0000000000001538 https://heart.lihaiyang.com/?p=detail&id=17937 Multi-arm multi-stage (MAMS) trials have gained popularity, due to their improved efficiency in evaluating multiple treatments. A traditional MAMS trial often decreases the expected sample size of the trial compared with just running a multi-arm approach, but with the drawback of an increase in maxi Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1002/sim.70642 https://heart.lihaiyang.com/?p=detail&id=4114 Vascular Interventional Radiologists (VIRs) frequently care for patients with high severity of illness, multiple comorbidities, and physiologic derangements. The incidence and prevalence of abnormal cardiac rhythms (dysrhythmias) in these patients is high, and these can quickly lead to hemodynamic i Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1016/j.tvir.2026.101110 https://heart.lihaiyang.com/?p=detail&id=17938 Accurate and efficient analysis of electrocardiogram (ECG) signals is essential for early detection of cardiac arrhythmias. However, many deep learning models suffer from limited generalization to unseen patients, reduced interpretability, and high computational demands. To address these challenges, Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.14814/phy2.70990 https://heart.lihaiyang.com/?p=detail&id=17939 BACKGROUND: Atrial fibrillation (AF) poses significant challenges for coronary CT angiography (CCTA) due to R-R interval variability, often necessitating high radiation dose protocols. Absolute phase gating, which uses fixed millisecond delays rather than percentage-based cardiac cycle timing, may o Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1002/acm2.70666 https://heart.lihaiyang.com/?p=detail&id=45332 Chronic kidney disease (CKD), a highly prevalent condition worldwide, is associated with increased thrombotic and bleeding risks. Thrombotic risks include heightened cardiovascular risk and that of venous thromboembolism, driven by endothelial dysfunction, and inflammation. Conversely, platelet dysf Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.31083/BJHM49737 https://heart.lihaiyang.com/?p=detail&id=51732 BACKGROUND: This study aimed to investigate the knowledge, attitudes, and practices (KAP) regarding premature ventricular contractions (PVCs) among patients. METHODS: A cross-sectional study was conducted from March to June 2025 at Yichun People's Hospital, enrolling patients with a confirmed diagno Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.3389/fpubh.2026.1879497 https://heart.lihaiyang.com/?p=detail&id=19733 BACKGROUND: Wearable cardioverter-defibrillators (WCDs) are equipped with the TRENDS remote-monitoring system, enabling continuous assessment of arrhythmias, physiological parameters, and patient-reported outcomes. This study evaluated the clinical utility of TRENDS-integrated WCD management and com Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.3390/s26123952 https://heart.lihaiyang.com/?p=detail&id=51733 INTRODUCTION: Bronchospasm requiring continuous inhaled albuterol is a common reason for pediatric intensive care unit (PICU) admission. Albuterol's racemic composition may contribute to adverse effects; therefore, levalbuterol [(R)-albuterol] may be used. This study aimed to determine if continuous Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1002/ppul.71779 https://heart.lihaiyang.com/?p=detail&id=7193 OBJECTIVE: Calpeptin, a calpain inhibitor with potential for treating inflammatory diseases, reduces extracellular vesicle (EV) secretion. While adipose tissue is a recognized target of calpeptin, its effects on lipid metabolism remain unknown. We investigated calpeptin's impact on fatty acid (FA) p Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1007/s00011-026-02280-z https://heart.lihaiyang.com/?p=detail&id=12570 BACKGROUND: Insulin resistance (IR) plays a significant role in the onset and progression of atrial fibrillation (AF). The single-point insulin sensitivity estimator (SPISE) index is a novel marker for assessing IR. This study aims to investigate the association between the SPISE index and the recur Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.2147/CIA.S608687 https://heart.lihaiyang.com/?p=detail&id=12571 BACKGROUND: Multimorbidity significantly affects prognosis in patients after transvenous lead extraction (TLE). The CHA2DS2-VASc and CHA2DS2-VA scores, widely used for stroke risk stratification in atrial fibrillation, include clinical factors that are also associated with long-term mortality. PURPO Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.2147/VHRM.S590625 https://heart.lihaiyang.com/?p=detail&id=21532 OBJECTIVE: To identify potential biomarkers of atrial fibrillation (AF) using bioinformatics, machine learning (ML) and experimental methods. METHODS: AF transcriptomic data were obtained from the GEO and MSigDB databases to screen for differentially expressed genes (DEGs) and inflammation-related g Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.12182/20260560503 https://heart.lihaiyang.com/?p=detail&id=21533 A 14-year-old castrated male spitz dog was presented with intermittent coughing. Physical examination revealed bradycardia and a grade 3/6 left apical systolic murmur. Thoracic radiographs demonstrated severe bulging of the aortic arch with focal dorsal deviation of the trachea. Echocardiography rev Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://heart.lihaiyang.com/?p=detail&id=21533 https://heart.lihaiyang.com/?p=detail&id=26910 Adults with congenital heart disease (ACHD) represent a rapidly growing patient population that is uniquely predisposed to rhythm disturbances. Arrhythmia mechanisms are shaped by congenital anatomy, prior surgical repairs, and progressive chamber remodeling, necessitating lesion-specific strategies Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.14797/mdcvj.1736 https://heart.lihaiyang.com/?p=detail&id=26911 ObjectivePostoperative atrial fibrillation, a prevalent complication following cardiac surgery, significantly increases patient morbidity and healthcare expenditures. Although dexmedetomidine has been proposed as a potential strategy to mitigate the risk of postoperative atrial fibrillation risk, ex Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1177/03000605261465578 https://heart.lihaiyang.com/?p=detail&id=23330 We present the case of a 72-year-old female with Fabry disease who developed an advanced interatrial conduction block and atrial fibrillation, a condition known as Bayés' syndrome. Fabry disease is an X-linked inherited lysosomal storage disorder that results in the accumulation of globotriaosylcera Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1111/anec.70220 https://heart.lihaiyang.com/?p=detail&id=29732 OBJECTIVE: To evaluate the predictive value of the Vasoactive Inotropic Score (VIS) for 28-day mortality in intensive care unit (ICU) patients with atrial fibrillation (AF)-related hemodynamic deterioration, to determine its optimal cutoff value, and to analyze its independent association with 28-da Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.3760/cma.j.cn121430-20260108-00018 https://heart.lihaiyang.com/?p=detail&id=48932 BACKGROUND: Left ventricular (LV) hypertrabeculation, formerly termed LV noncompaction, is a heterogeneous myocardial entity linked to adverse cardiovascular outcomes. This study evaluated embolic risk in patients with dilated cardiomyopathy (DCM) according to the presence of hypertrabeculation and Mon, 30 Nov -001 00:00:00 +0805 心律失常 https://doi.org/10.1161/CIRCULATIONAHA.125.078536