https://heart.lihaiyang.com 心血管文献检索平台 - 最新收录论文 zh-CN https://heart.lihaiyang.com/?p=detail&id=187 Preclinical evidence suggests that time-restricted eating (TRE) exerts beneficial metabolic and cardiovascular effects by ameliorating inflammation and modulating immune cell function. However, the effect in patients with established coronary artery disease remains unknown. In this prospective, rand Fri, 20 Mar 2026 00:00:00 +0800 心肌病 https://doi.org/10.1161/JAHA.125.048092 https://heart.lihaiyang.com/?p=detail&id=2 Transthyretin amyloidosis with cardiomyopathy is a progressive, fatal disease characterized by deposition of extracellular misfolded transthyretin (TTR) in the myocardium. Eplontersen is an N-acetylgalactosamine ligand-conjugated antisense oligonucleotide targeting hepatocyte TTR messenger RNA to re Thu, 01 Jan 2026 00:00:00 +0800 心肌病 https://doi.org/10.1161/CIRCHEARTFAILURE.126.014205 https://heart.lihaiyang.com/?p=detail&id=86 Current diagnostic criteria for transthyretin amyloid (ATTR) cardiomyopathy (ATTR-CM) emphasize increased left ventricular (LV) wall thickness, potentially delaying recognition of early myocardial involvement. We evaluated whether combining ECG (S-wave amplitude in lead aVR, SaVR) with echocardiogra Thu, 01 Jan 2026 00:00:00 +0800 心肌病 https://doi.org/10.1093/ehjimp/qyag058 https://heart.lihaiyang.com/?p=detail&id=102 Arrhythmogenic Cardiomyopathy (ACM) is a primary disorder of the myocardium characterized by a high propension for ventricular arrhythmias (VAs) and sudden cardiac death (SCD). Several genes have been associated with the development of aggressive forms of ACM, the most common of which is the one enc Thu, 01 Jan 2026 00:00:00 +0800 心肌病 https://doi.org/10.1016/j.hrthm.2026.03.1942 https://heart.lihaiyang.com/?p=detail&id=113 Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive disorder caused by destabilization of serum transthyretin (sTTR). Acoramidis, an approved therapy that achieves near-complete (≥90%) sTTR stabilization, demonstrated clinical benefit through month 30 in ATTRibute-CM, which was increment Thu, 01 Jan 2026 00:00:00 +0800 心肌病 https://doi.org/10.1001/jamacardio.2026.0819 https://heart.lihaiyang.com/?p=detail&id=116 Genetic diagnosis has become increasingly important to guide clinical decision-making for patients with dilated cardiomyopathy (DCM). Pathogenic or likely pathogenic (P/LP) missense variants in the gene RBM20 cause a highly penetrant arrhythmogenic DCM, but the role of RBM20 truncating variants (RBM Thu, 01 Jan 2026 00:00:00 +0800 心肌病 https://doi.org/10.1001/jamacardio.2026.0401 https://heart.lihaiyang.com/?p=detail&id=18432 Myocarditis and pericarditis represent a broad spectrum of inflammatory heart diseases and are important differential diagnoses in patients presenting with chest pain, heart failure, or arrhythmias. Diagnosis is often challenging due to non-specific clinical presentation and biomarkers. Growing reco Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.23785/TU.2026.03.005 https://heart.lihaiyang.com/?p=detail&id=18433 Domoic acid (DA) is a well-known seafood toxin produced by some species of marine phytoplankton in the genus Pseudo-nitzschia during harmful algal blooms (HABs). Acute toxic exposures induce overt clinical signs of neuroexcitotoxicity, such as seizures in mammals due to overstimulation of glutamate Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.3390/md24060210 https://heart.lihaiyang.com/?p=detail&id=11270 Background Cardiac gallium 68-labeled fibroblast activation protein inhibitor (FAPI)-4 (68Ga-FAPI-4) PET/MRI allows simultaneous assessment of cardiac tissue characteristics, function, and molecular remodeling in myocardial diseases. An integrated workflow for nonischemic dilated cardiomyopathy (DCM Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1148/radiol.252706 https://heart.lihaiyang.com/?p=detail&id=20230 PURPOSE: Lower extremity ischemia-reperfusion injury (IRI) triggers systemic inflammation and oxidative stress, causing myocardial remote ischemia-reperfusion injury (MIRI). Current treatments are limited. METHODS: Male Sprague-Dawley rats (n = 6 per group) were assigned to Sham, I/R, I/R + colchici Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1111/fcp.70102 https://heart.lihaiyang.com/?p=detail&id=33032 BACKGROUND Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced malignancies but can cause life-threatening immune-related adverse events. Myocarditis, myositis, and myasthenia gravis (MMM) overlap syndrome is a rare, highly morbid complication with high mortality. Most cas Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.12659/AJCR.953173 https://heart.lihaiyang.com/?p=detail&id=45832 Takotsubo syndrome (TTS) frequently presents with chest pain, ST-segment elevation, and troponin elevation, closely mimicking acute coronary syndrome, and can be complicated by acute heart failure and cardiogenic shock. In a subset of patients, dynamic left ventricular outflow tract obstruction (LVO Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1177/23247096261475113 https://heart.lihaiyang.com/?p=detail&id=11275 BACKGROUND: Patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) or Takotsubo syndrome (TS) often suffer from poor mental health and low quality-of-life post event, with no current evidence-based treatments available. This study aimed to evaluate the effects of an inter Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1161/JAHA.125.047311 https://heart.lihaiyang.com/?p=detail&id=7692 INTRODUCTION: Heatstroke is a life-threatening condition defined by a core body temperature exceeding 40° C and central nervous system dysfunction. Its onset is potentiated by high heat and humidity, especially if superimposed upon high thermal loads due to exertion or to impaired ability to sweat a Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.5811/westjem.53045 https://heart.lihaiyang.com/?p=detail&id=23830 Combined heart and kidney transplant is a rare but valuable treatment option for selected patients with end -stage cardiac and renal failure. We present the long -term outcome of a 27 -year -old man with pulmonary stenosis previously treated with valvuloplasty in 1998, who subsequently developed end Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.6002/ect.2026.0088 https://heart.lihaiyang.com/?p=detail&id=23831 Cardiogenetics plays an increasingly important role in managing cardiovascular diseases, owing to the major impact of genetic data on diagnosis, risk stratification, therapeutic decision-making, and family-based prevention. Many cardiomyopathies, channelopathies, and other entities have a genetic ba Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.53738/REVMED.2026.22.969.48836 https://heart.lihaiyang.com/?p=detail&id=23832 The most common hereditary transthyretin (ATTRv) amyloidosis variant in the United States, Val122Ile (p.Val142Ile), is predominantly detected in populations of African ancestry. In this narrative review, we highlight the current challenges and discuss priority focus areas to improve the timely diagn Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1007/s10741-026-10651-1 https://heart.lihaiyang.com/?p=detail&id=36632 CTNNA3 encodes αT-catenin, an intercalated disc (ICD) protein essential for cardiomyocyte coupling. Human omics studies have shown reduced CTNNA3 expression, ICD ultrastructural disruption, and dilated cardiomyopathy (DCM)-associated hyperphosphorylation of αT-catenin. Direct RNA-level evidence link Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1155/humu/2079958 https://heart.lihaiyang.com/?p=detail&id=43032 BACKGROUND: Early diagnosis of acute myocarditis (AMC) is crucial due to its rapid progression and high mortality rate. Initial symptoms such as fever, abdominal pain, and vomiting are nonspecific and pose challenges for clinicians in distinguishing AMC from acute gastroenteritis (AGE). METHODS: We Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1111/ped.70492 https://heart.lihaiyang.com/?p=detail&id=49432 BACKGROUND: The triglyceride-glucose(TyG) index, a surrogate marker of insulin resistance, has been linked to cardiac dysfunction; however, its underlying associated pathways in patients with type 2 diabetes mellitus(T2DM) remain unclear. This study used cardiac magnetic resonance(CMR) to explore th Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1186/s12933-026-03308-8 https://heart.lihaiyang.com/?p=detail&id=49433 Regular physical exercise can induce a multifaceted cardioprotective phenotype characterized by improved Ca2⁺ handling, mitochondrial resilience, redox buffering, autonomic regulation, and resistance to ischemia-reperfusion injury. Ca2⁺/calmodulin-dependent protein kinase II (CaMKII), particularly c Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1007/s13577-026-01425-w https://heart.lihaiyang.com/?p=detail&id=44832 BACKGROUND: Brazil presents regional variations in mortality from cardiomyopathies, influenced by demographic characteristics, socioeconomic inequalities, and differences in access to health services. Between 2001 and 2021, 272,448 deaths from the disease were recorded in the country. OBJECTIVE: To Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.36660/abc.20260064 https://heart.lihaiyang.com/?p=detail&id=32033 BACKGROUND: Clinical monitoring of patients with heart failure or cardiomyopathy is facilitated by detailed assessment of cardiac loading conditions. Specifically, alterations in preload and afterload may unmask pathology through effects on ventricular pressure-volume (PV) relations. Therefore, the Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1111/cpf.70081 https://heart.lihaiyang.com/?p=detail&id=12070 Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous myocardial disease that usually arises from mutations in key sarcomeric proteins, particularly MYBPC3 and MYH7. Current pharmacological treatments, such as myosin inhibitors, calcium channel blockers, and β-blockers, reduce symptoms bu Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1002/biot.70262 https://heart.lihaiyang.com/?p=detail&id=46632 OBJECTIVE: Sepsis-associated myocardial injury (SICM) is one of the most common and severe complications of sepsis. The present study aimed to analyze research trends, collaborative networks, and knowledge dissemination in SICM over the past decade using bibliometric methods, thereby providing a ref Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1097/MD.0000000000050014 https://heart.lihaiyang.com/?p=detail&id=33833 莱姆病是由蜱虫传播、伯氏疏螺旋体感染所致的自然疫源性疾病，莱姆病心脏炎是其严重的心血管并发症，发生率为1%~10%。该病以房室传导阻滞及心肌炎症为主要表现，主要累及心脏传导系统，可引发心律失常甚至猝死。诊断需结合流行病学史、临床症状与血清学检测，推荐采用“酶免疫分析联合C6肽检测、心电图初筛，蛋白免疫印迹法最终确证”的流程，并注意与病毒性心肌炎等疾病鉴别。2024年美国疾病控制与预防中心/欧洲心脏病学会采纳改良用药方案中指出，轻中度患者可口服多西环素；临时起搏器应用具有明确适应证，而永久起搏器需谨慎使用。预防以加强野外蜱虫防护为核心，目前VLA15疫苗已进入Ⅲ期临床试验阶段。未来研究将聚焦缩短 Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.3760/cma.j.cn112148-20260113-00030 https://heart.lihaiyang.com/?p=detail&id=46633 BACKGROUND: Targeted therapy using myosin inhibitors represents a groundbreaking advancement in the management of hypertrophic cardiomyopathy (HCM). This study conducts a comprehensive bibliometric analysis to map the research landscape indexed in the Web of Science Core Collection, identify key tre Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1097/MD.0000000000050034 https://heart.lihaiyang.com/?p=detail&id=33834 线粒体相关内质网膜（MAMs）是线粒体与内质网通过物理接触形成的特殊功能结构域，介导两大细胞器间的物质转运与信息交流，在空间分布与生物学功能上均实现高度偶联。脓毒症心肌病是脓毒症进程中出现的可逆性心肌功能损伤。现有研究表明MAMs可通过调控钙信号传导、自噬、线粒体动力学、内质网应激及炎症等关键通路，参与脓毒症心肌病的发生与发展。该文就MAMs的结构特征、生物学功能及其在脓毒症心肌病中的作用机制作一综述，以期为该病的防治提供潜在新靶点。. Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.3760/cma.j.cn112148-20260319-00188 https://heart.lihaiyang.com/?p=detail&id=33836 In patients with myocardial infarction (MI), the level of sphingolipids, such as ceramide (Cer), is elevated and is associated with an increased risk of progression towards heart failure (HF). Dihydroceramide desaturase 1 (DES1) catalyses the conversion of dihydroceramide (dhCer) into Cer in the de Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.3390/ijms27135776 https://heart.lihaiyang.com/?p=detail&id=33837 Circulating ketone bodies (KBs), particularly β-hydroxybutyrate (β-HB), have emerged as metabolites with dual roles as both oxidative fuels and metabolic signaling molecules. Beyond serving as an alternative energy substrate, β-HB regulates diverse pathways involved in oxidative stress, inflammation Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.3390/ijms27135716 https://heart.lihaiyang.com/?p=detail&id=8494 Eicosanoids and their receptors act as key regulators of inflammation, calcium homeostasis, mitochondrial function, and cardiomyocyte survival, thereby contributing to the onset and progression of cardiac dysfunction. This review aims to summarize the evidence to underscore the pivotal role of eicos Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.3390/ijms27114849 https://heart.lihaiyang.com/?p=detail&id=13870 BACKGROUND: Recently under the European Society of Cardiology (ESC) EURObservational Research Programme (EORP) PPCM registry the first predictive score was derived. This study sought to test the validity of this predictive score in a cohort of women with PPCM in Uganda. METHODS: 80 PPCM cases enroll Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.5830/CVJA-2025-099 https://heart.lihaiyang.com/?p=detail&id=33839 BACKGROUND: Acute myocardial infarction is a leading cause of death globally. Percutaneous coronary intervention is the primary treatment to restore blood flow to the affected myocardium, but reperfusion can cause myocardial injury, affecting the prognosis of patients with acute myocardial infarctio Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1155/cdr/8401037 https://heart.lihaiyang.com/?p=detail&id=8496 Purpose To evaluate multiparametric cardiac MRI for assessing myocardial inflammation, fibrosis, and spatiotemporal distribution in autoimmune myocarditis, with histologic reference. Materials and Methods This study (December 2022 to January 2024) included 84 BALB/c mice (42 with experimental autoim Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1148/ryct.250488 https://heart.lihaiyang.com/?p=detail&id=8497 Myocardial ischemia-reperfusion injury (MIRI) remains a major driver of infarct expansion, adverse remodeling, and poor outcomes after reperfusion therapy, yet mechanism-based treatments remain limited. Emerging evidence suggests that MIRI is not simply the additive result of oxidative stress and st Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.3389/fimmu.2026.1848067 https://heart.lihaiyang.com/?p=detail&id=8498 Reverse takotsubo cardiomyopathy, a rare variant of stress-induced cardiomyopathy, is characterized by basal hypokinesis with apical sparing and can be associated with neurological insults. Prompt recognition is essential to avoid unnecessary invasive interventions and to guide appropriate supportiv Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1080/08998280.2025.2605609 https://heart.lihaiyang.com/?p=detail&id=18230 OBJECTIVES: To investigate the role of lactate in myocardial ischemia-reperfusion (MIR)-induced gastric mucosal injury. METHODS: Thirty C57BL/6J mice were randomized into sham-operated group, MIR (45 min ischemia and 2 h reperfusion) group, and MIR+LDHAI group, and gastric mucosal injury was assesse Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.12122/j.issn.1673-4254.2026.06.07 https://heart.lihaiyang.com/?p=detail&id=18231 BACKGROUND: To explore the mechanism of Tongmai yangxin pills (TMYX) for improving myocardial ischemia-reperfusion injury (MIRI) in rats. METHODS: In a SD rat model of MIRI, the therapeutic effects of TMYX were evaluated by cardiac echography, measurement of myocardial infarction area, and examinati Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.12122/j.issn.1673-4254.2026.06.01 https://heart.lihaiyang.com/?p=detail&id=52032 Iron overload cardiomyopathy (IOC) remains an important cause of morbidity and mortality in patients with hereditary haemochromatosis and transfusion-dependent conditions such as haemoglobinopathies. The condition arises when excess iron, due to increased intestinal iron absorption or repetitive tra Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1007/s10741-026-10663-x https://heart.lihaiyang.com/?p=detail&id=39233 BACKGROUND: Chagas disease affects millions worldwide and remains a leading cause of cardiomyopathy in Latin America. Early diagnosis remains challenging in endemic regions. Artificial intelligence (AI)-based electrocardiography (ECG) analysis may offer a low-cost strategy for large-scale screening Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.36660/abc.20260032 https://heart.lihaiyang.com/?p=detail&id=32834 INTRODUCTION: Loss-of-function variants in NONO cause an X-linked syndromic neurodevelopmental disorder (MRXS34), characterized by developmental delay, corpus callosum abnormalities, dysmorphic features, feeding difficulties, and congenital heart disease, most commonly left ventricular noncompaction Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1002/mgg3.70261 https://heart.lihaiyang.com/?p=detail&id=39234 Hypertrophic cardiomyopathy (HCM) is a genetic disease associated with sudden cardiac death. Variants in alpha-actinin-2 (ACTN2), a Z-disc protein that anchors actin thin filaments have been implicated in HCM, yet their structural consequences remain poorly defined. Here, we characterise seventeen H Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1038/s41467-026-75392-z https://heart.lihaiyang.com/?p=detail&id=39235 Seizure-like episodes may occasionally arise from cardiovascular causes rather than primary neurological disease, leading to diagnostic delay. We report an adolescent girl who presented with recurrent generalised tonic episodes with cyanosis and transient loss of consciousness. Initial evaluation fo Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1136/bcr-2026-274228 https://heart.lihaiyang.com/?p=detail&id=7492 Chagas disease, caused by Trypanosoma cruzi, remains one of the leading infectious causes of non-ischemic cardiomyopathy worldwide. Although an estimated 6-7 million individuals are chronically infected, 20-30% will develop Chagas cardiomyopathy (CCM), a progressive myocardial disease characterised Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1007/s10741-026-10645-z https://heart.lihaiyang.com/?p=detail&id=39236 Primary carnitine deficiency (PCD) is an autosomal recessive disorder caused by mutations in the SLC22A5 gene, which encodes the organic cation transporter 2 (OCTN2). These mutations impair carnitine transport and fatty acid metabolism, leading to a wide range of clinical symptoms, from mild fatigue Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1111/jcmm.71273 https://heart.lihaiyang.com/?p=detail&id=21830 Hypertrophic cardiomyopathy (HCM) variants in genes encoding the myosin heavy chain (MHC) (MYH7), myosin light chains (MYL2 and MYL3), and cardiac myosin binding protein-C (cMyBP-C, MYBPC3) lead to cardiac hypertrophy, with abnormal contractility, relaxation, and energy consumption. Here, we defined Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1073/pnas.2529234123 https://heart.lihaiyang.com/?p=detail&id=41032 BACKGROUND: This case report describes a rare presentation of rippling muscle disease (RMD) due to a pathogenic CAV3 variant, manifesting with myocarditis-like cardiac involvement in an adolescent patient. To the best of our knowledge, this represents an exceedingly rare pediatric case of RMD associ Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.24953/turkjpediatr.2026.7755 https://heart.lihaiyang.com/?p=detail&id=34633 BACKGROUND: Hypertrophic obstructive cardiomyopathy (HOCM) causes dynamic left ventricular outflow tract (LVOT) obstruction and disabling symptoms; many patients do not respond to conventional agents. Mavacamten, a selective cardiac myosin inhibitor, improves gradients, but the dose-time response in Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1111/echo.70540 https://heart.lihaiyang.com/?p=detail&id=27210 BACKGROUND: Cardiovascular disease is the leading cause of death in end-stage renal disease (ESRD). While platelet activation and monocyte inflammation are hallmarks of uremia, how platelet-derived factors drive monocyte-mediated cardiac remodeling remains elusive. We investigated the role of platel Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1007/s00011-026-02311-9 https://heart.lihaiyang.com/?p=detail&id=27212 BACKGROUND: Antipsychotic-induced myocarditis is a rare but potentially fatal adverse event associated with antipsychotic treatment. Trimetazidine (TMZ) and coenzyme Q10 (CoQ10) have shown potential cardioprotective effects. Thus, they may represent adjunctive therapeutic candidates for antipsychoti Mon, 30 Nov -001 00:00:00 +0805 心肌病 https://doi.org/10.1002/cns.71009