https://heart.lihaiyang.com 心血管文献检索平台 - 最新收录论文 zh-CN https://heart.lihaiyang.com/?p=detail&id=178 高甘油三酯血症是动脉粥样硬化性心血管疾病的既定危险因素，最近被牵连在腹主动脉瘤的发病机制中。然而，其在胸主动脉瘤和夹层（TAAD）中的作用仍不确定。本研究利用GPIHBP1（糖基磷脂酰肌醇锚定高密度脂蛋白结合蛋白1）基因敲除小鼠作为高甘油三酯血症模型，探讨了高甘油三酯血症对实验性TAAD的影响。通过口服β-氨基丙腈在3-4周龄小鼠中诱导TAAD，持续28天。尽管GPIHBP1基因敲除小鼠在β-氨基丙腈治疗期间表现出进行性高甘油三酯血症，但与野生型同窝小鼠相比，TAAD发生率、死亡率或受累主动脉节段与主动脉全长之比均无显著差异。组织病理学和分子分析显示，两种基因型小鼠胸主动脉的弹性蛋白断裂、细胞 Thu, 19 Mar 2026 00:00:00 +0800 血脂 https://doi.org/10.1161/ATVBAHA.126.324300 https://heart.lihaiyang.com/?p=detail&id=174 On the basis of seminal genetic discoveries, proprotein convertase subtilisin/kexin Type 9 (PCSK9) inhibitors were developed as a new class of LDL cholesterol-lowering drug, with a potency on par with and on top of high-intensity statins and an excellent safety profile. A series of large cardiovascu Tue, 17 Mar 2026 00:00:00 +0800 血脂 https://doi.org/10.1093/eurheartj/ehag148 https://heart.lihaiyang.com/?p=detail&id=170 准确估计低密度脂蛋白胆固醇（LDL-C）对于心血管风险评估和监测至关重要。由于β定量法操作繁琐且不适用于常规使用，已开发了多种方程来估计LDL-C浓度。然而，在甘油三酯水平升高、低LDL-C或非空腹样本等临床条件下，传统方程的性能可能下降。本研究比较了常规估计公式（Friedewald、Martin-Hopkins和Sampson-Nielsen公式）与机器学习模型在估计血清LDL-C方面的性能。研究使用了一个大型临床实验室数据库，涵盖了广泛的脂质谱特征。结果显示，机器学习模型在广泛的临床条件下均优于传统方程，特别是在甘油三酯升高和低LDL-C水平的情况下。机器学习方法通过利用多种脂质参数之间 Tue, 10 Mar 2026 00:00:00 +0800 血脂 https://doi.org/10.1016/j.plabm.2026.e00524 https://heart.lihaiyang.com/?p=detail&id=34 In individuals with heterozygous familial hypercholesterolemia (HeFH), it is uncertain whether and to what extent the reduction in low-density lipoprotein cholesterol (LDL-C) with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor therapy is dependent on the residual functional activity Thu, 01 Jan 2026 00:00:00 +0800 血脂 https://doi.org/10.1001/jamacardio.2026.0879 https://heart.lihaiyang.com/?p=detail&id=121 The cardiovascular benefits of eicosapentaenoic acid ethyl ester (EPA-E) in MACE reduction might extend beyond its triglyceride (TG)-lowering effects. However, the mechanism behind remains unknown. This study investigated whether EPA-E exerts cardioprotection in the setting of myocardial infarction Thu, 01 Jan 2026 00:00:00 +0800 血脂 https://doi.org/10.1093/eurheartj/ehag187 https://heart.lihaiyang.com/?p=detail&id=16130 BACKGROUND: This study aims to investigate the expression changes of FTX (long noncoding RNA) in polycystic ovary syndrome (PCOS) and its relationship with insulin resistance and lipid metabolism, thereby providing new directions for the diagnosis and treatment of PCOS. METHODS: A total of 69 PCOS p Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1111/jog.70320 https://heart.lihaiyang.com/?p=detail&id=50692 OBJECTIVES: Dyslipidemia is prevalent among Nigerians with diabetes mellitus (DM), but its treatment has not been well-studied. The objective of this study was to determine the prevalence, treatment rates and control of dyslipidemia among DM patients in northern Nigeria. METHODS: We conducted a mult Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1371/journal.pone.0346350 https://heart.lihaiyang.com/?p=detail&id=16134 In this study, we evaluated the association between UPFs with HTGW in relation to oxidative stress and inflammation in Iranian adults, as no previous study had assessed these altogether. This cross-sectional study consisted of a sample of 528 Iranian adults (45.6% of them females). The dietary intak Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1039/d5fo05626h https://heart.lihaiyang.com/?p=detail&id=16910 BACKGROUND: Age-related cataract (ARC) is the leading cause of global blindness in the elderly. An unbalanced metabolic state is known to contribute to lens epithelial cell dysfunction and ARC pathogenesis. However, the relationship between hyperlipidemia and ARC remains controversial. METHODS: In t Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.2147/CIA.S598237 https://heart.lihaiyang.com/?p=detail&id=41492 INTRODUCTION: Dyslipidemia accompanied by metabolic syndrome substantially elevates cardiovascular risk by clustering multiple risk factors, including abdominal obesity, hypertension, hyperglycemia, and atherogenic dyslipidemia. The prevalence of both conditions is rising in Korea, underscoring the Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3389/fendo.2026.1862394 https://heart.lihaiyang.com/?p=detail&id=10531 CONTEXT: Zexie Decoction (ZXD) is a classical traditional Chinese medicine prescription that has long been used for the treatment of hyperlipidemia. However, its material basis and underlying mechanisms remain unclear. OBJECTIVE: This research aims to explore the effective compounds and lipid-loweri Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1080/13880209.2026.2687990 https://heart.lihaiyang.com/?p=detail&id=10532 BACKGROUND: In diabetic kidney disease (DKD), dyslipidemia accelerates renal decline and heart failure risk, making Cardio-Renal-Metabolic (CRM) risk reduction critical. The bidirectional relationship between cardiac and renal dysfunction further highlights the necessity of lipid-lowering therapy as Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3389/fendo.2026.1842847 https://heart.lihaiyang.com/?p=detail&id=10533 BACKGROUND: Cardiovascular risk in type 1 diabetes mellitus (T1DM) is frequently underestimated in daily clinical practice. The aim was therefore to evaluate lipid management in patients with T1DM according to current guidelines, and agreement in target attainment across three recommended lipid biom Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3389/fendo.2026.1819019 https://heart.lihaiyang.com/?p=detail&id=51493 Hypertriglyceridemia (HTG) frequently occurs in population with abnormal glucose metabolism (AGM), exacerbating risk. In our preliminary researches, we have screened hsa_circ_0000973 and MBOAT2 as the possible regulatory elements of HTG in AGM patients. This study enrolled 142 AGM subjects (71 with Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1093/hmg/ddag074 https://heart.lihaiyang.com/?p=detail&id=10534 BACKGROUND: Children and adolescents with type 1 diabetes mellitus (T1DM) are at increased risk of future cardiovascular disease, and dyslipidemia is one of the major modifiable contributors to this risk. In recent years, atherogenic lipid indices have been considered more sensitive markers of cardi Mon, 30 Nov -001 00:00:00 +0805 血脂 https://heart.lihaiyang.com/?p=detail&id=10534 https://heart.lihaiyang.com/?p=detail&id=10535 PURPOSE OF REVIEW: This review aims to summarize current advances in children and adolescent hyperlipidemia, and re-evaluate the unique epidemiology, genetic and environmental causes, and pathophysiological mechanisms of the condition. RECENT FINDINGS: Although lipid-lowering drugs have significantl Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1007/s13679-026-00727-2 https://heart.lihaiyang.com/?p=detail&id=45095 Lipoprotein apheresis (LA) is used for severe dyslipidemia but can remove non-lipid plasma constituents. In this systematic review and meta-analysis, we synthesized evidence on LA-associated changes in albumin, total protein (TP), and α2-macroglobulin (α2M). PubMed, Scopus, and Web of Science were s Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1002/jca.70160 https://heart.lihaiyang.com/?p=detail&id=45096 INTRODUCTION: Statin therapy is associated with an increased risk of dysglycaemia and new-onset type 2 diabetes, which compromises patient adherence. Ursodeoxycholic acid (UDCA), a hepatoprotective drug, has shown potential for improving glycaemic control, but its role in preventing statin-induced d Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1136/bmjopen-2026-117417 https://heart.lihaiyang.com/?p=detail&id=45097 Hyperlipidemia is a major risk factor of atherosclerotic cardiovascular disease and remains a major global health concern. While statins remain the cornerstone of therapy, a subset of patients require additional interventions due to inadequate response, intolerance or more stringent LDL goals. Recen Mon, 30 Nov -001 00:00:00 +0805 血脂 https://heart.lihaiyang.com/?p=detail&id=45097 https://heart.lihaiyang.com/?p=detail&id=21290 PURPOSE OF REVIEW: This review aims to synthesize recent evidence to clarify the causal and mechanistic roles of lipid metabolism disorders as core drivers of type 2 diabetes mellitus (T2DM), and to summarize emerging therapeutic advances targeting key nodes within pathophysiological cascade, thereb Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1007/s13679-026-00732-5 https://heart.lihaiyang.com/?p=detail&id=45098 Simvastatin (ST) has limited long-term clinical utility due to its adverse effects. The combination of Hedan tablets and simvastatin (HST) exhibits superior lipid-lowering effects, but its mechanism remains unclear. This study aims to investigate the effects of HST in hyperlipidemic rats based on 16 Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1002/bmc.70559 https://heart.lihaiyang.com/?p=detail&id=10539 Aims: Murine studies show a promising effect of high-fiber β-glucan on glycemic control and serum lipids. In addition, β-glucan has recently been found to have strong antioxidant and immunomodulatory effects. Oat flakes are a natural source of β-glucan. However, the effects of oat flakes on glycemic Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18111802 https://heart.lihaiyang.com/?p=detail&id=45099 Background: Hyperlipidemia represents a pivotal risk factor for multiple cardiovascular and metabolic diseases, creating an urgent demand for safe, effective novel therapeutic interventions. Resveratrol (RES), a natural plant polyphenol, has exhibited great potential as a hypolipidemic agent for hyp Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18142384 https://heart.lihaiyang.com/?p=detail&id=10540 Background/Objectives: Dyslipidemia and hepatic lipid buildup are key features of cardiometabolic disorders caused by high-fat, high-cholesterol diets. Both curcumin and flaxseed oil have been shown to improve lipid metabolism through different mechanisms. This study examined the effects of combinin Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18111747 https://heart.lihaiyang.com/?p=detail&id=45100 Background and Objectives: Red yeast rice (RYR)-containing food supplements are widely used for mild-to-moderate hypercholesterolemia, but their post-marketing safety remains relevant. This study characterized their safety profile within a structured multicompany nutrivigilance framework. Methods: S Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18142302 https://heart.lihaiyang.com/?p=detail&id=10541 Background/Objectives: Hypertriglyceridemia is a critical cardiovascular risk factor, and the probiotic combination of Latilactobacillus curvatus HY7601 and Lactiplantibacillus plantarum KY1032 (HY+KY) has emerged as a potential therapeutic strategy, though clinical validation in adults with mild hy Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18111713 https://heart.lihaiyang.com/?p=detail&id=45101 Dyslipidemia in adolescents represents an early and potentially modifiable stage in the lifelong trajectory of cardiovascular disease. However, optimal lipid screening strategies in this age group remain controversial, particularly regarding feasibility, biological relevance, and reliance on family Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18142285 https://heart.lihaiyang.com/?p=detail&id=45103 Familial hypercholesterolemia (FH) and familial hypertriglyceridemia (FHTG) represent a spectrum of inherited conditions with profoundly different etiologies, risk profiles, and therapeutic implications. Despite decades of clinical experience, their formal diagnostic definitions remain rooted in fra Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/medicina62071257 https://heart.lihaiyang.com/?p=detail&id=10547 Noncommunicable diseases (NCDs) remain the leading cause of death worldwide, with unhealthy diets and insufficient physical activity as major contributing factors. The Planetary Health Diet is a sustainable dietary pattern linked to chronic diseases, but studies in Asian populations remain limited. Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1371/journal.pone.0350821 https://heart.lihaiyang.com/?p=detail&id=10548 PURPOSE OF REVIEW: Familial hypercholesterolemia (FH) is a common monogenic lipid disorder, characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and a markedly increased risk of atherosclerotic cardiovascular disease (ASCVD). Although the genetic prevalence of FH does not d Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1007/s11883-026-01431-1 https://heart.lihaiyang.com/?p=detail&id=48692 BACKGROUND: People taking antipsychotic medicines and those with severe mental illness experience elevated cardiovascular risk compared to the general population which is not adequately addressed by existing guidelines. Increases in lipid levels can occur soon after starting antipsychotics but often Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1093/schbul/sbag086 https://heart.lihaiyang.com/?p=detail&id=18491 Avasimibe, a cholesterol-lowering drug with proven safety in clinical trials, has also been repositioned as an anticancer agent in various preclinical investigations. A study from our group reported that hypercholesterolemia promotes hepatocellular carcinoma (HCC) cell survival and impairs the cytot Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1007/s12038-026-00593-z https://heart.lihaiyang.com/?p=detail&id=11330 BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors demonstrate significant lipid-lowering effects, but the widespread use of anti-PCSK9 monoclonal antibodies remains limited. PURPOSE: This study is aimed at understanding patients' real-world experiences with anti-PCSK9 mono Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1155/cdr/8814045 https://heart.lihaiyang.com/?p=detail&id=33092 Both HIV diagnosis and antiretroviral therapy (55.1%) increase the risk of developing lipid profile abnormalities. This has led the European Society of Cardiology, in its 2025 update on the management of dyslipidemias, to incorporate statin therapy in patients older than 40 years with an HIV diagnos Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.5281/zenodo.19076165 https://heart.lihaiyang.com/?p=detail&id=39492 OBJECTIVE: To evaluate the effect of taurine supplementation on the lipid profile of male hypothyroid Wistar rats. MATERIALS AND METHODS: Adult male Wistar rats were induced to hypothyroidism by treatment with 0.03% methimazole in drinking water. After 21 days, half of the hypothyroid animals receiv Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.20945/2359-4292-2026-0078 https://heart.lihaiyang.com/?p=detail&id=7750 Introduction: Managing obesity and lipid levels is essential for the prevention of chronic diseases. Despite clinical guidelines emphasizing lifestyle interventions, the long-term sex- and age-specific trends in walking, obesity and triglyceride in South Korea insufficiently understood. Methods: Thi Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1177/00469580261460622 https://heart.lihaiyang.com/?p=detail&id=7751 BACKGROUND: Drug resistance phenomenon has become a serious problem in the lipid lowering drugs in the treatment of cardiac and dyslipidemic patients. Statins are the mainstay pharmacological treatment for dyslipidemia, metabolized by CYP3A4 gene. CYP3A4 genetic variants are involved in statins resi Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.36721/PJPS.2026.39.8.220.1 https://heart.lihaiyang.com/?p=detail&id=22090 OBJECTIVE: To assess changes in lipid-lowering therapy (LLT) use and low-density lipoprotein cholesterol (LDL-C) goal attainment through 1-year follow-up in patients stratified by diabetes status in SANTORINI (Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvas Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1136/bmjopen-2025-108737 https://heart.lihaiyang.com/?p=detail&id=43092 Objective: To analyze the association between fine particulate matter (PM2.5) exposure and dyslipidemia, and the potential modifying role of dietary factors in children and adolescents in rural China. Methods: A multi-stage cluster random sampling method was applied to conduct questionnaire survey, Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3760/cma.j.cn112338-20251120-00843 https://heart.lihaiyang.com/?p=detail&id=38492 AIMS: Increased waist-hip ratio (WHR) increases free fatty acid (FFA) flux, contributing to dysglycemia and dyslipidemia in Europeans. We examined these phenomena in non-Europeans, a group with higher prevalence of metabolic disease. METHODS: We undertook sex-stratified analyses of WHR, body composi Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1155/jobe/5149353 https://heart.lihaiyang.com/?p=detail&id=51292 本文报道1例因重度肥胖接受袖状胃切除术的女性，术后8个月体重下降60.0 kg，继而出现血胆固醇、低密度脂蛋白胆固醇水平较术前显著升高。在排除其他病因后，对患者进行饮食干预治疗2个月，其体重从35.0 kg逐渐增至38.1 kg，血脂水平逐渐降至正常范围，在后续随访中，患者体重增至40.0 kg，血脂水平未反弹。. Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3760/cma.j.cn112138-20260318-00157 https://heart.lihaiyang.com/?p=detail&id=24670 BACKGROUND: Dyslipidemia is a metabolic factor associated with reproductive outcomes, but evidence on couple-level dyslipidemia in IVF/ICSI remains limited. OBJECTIVE: To investigate associations of dyslipidemia in both partners with embryological and cumulative pregnancy outcomes in couples undergo Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3389/fendo.2026.1796100 https://heart.lihaiyang.com/?p=detail&id=24671 INTRODUCTION: High-density lipoprotein (HDL) serves as a key protective factor against elevated low-density lipoprotein cholesterol (LDL-C) levels in patients with familial hypercholesterolemia (FH). This study aimed to assess whether HDL's ability to acquire free cholesterol (FC) from triglyceride- Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1002/edm2.70269 https://heart.lihaiyang.com/?p=detail&id=46692 The current study was designed to investigate the outcome of alcohol herbal beverages and ethanol consumption in high-fat diet-induced cardiometabolic syndrome (indices) in rats. The study consists of eight groups of 10 rats per cage. Groups 1-4 were fed a standard normal diet while groups 5-8 were Mon, 30 Nov -001 00:00:00 +0805 血脂 https://heart.lihaiyang.com/?p=detail&id=46692 https://heart.lihaiyang.com/?p=detail&id=46693 Dyslipidemia negatively impacts the development of nonalcoholic fatty liver disease (NAFLD); yet, the specific relationship between non-high-density lipoprotein cholesterol (non-HDL-C) and NAFLD has not been previously examined. This study aims to explore the association between levels of non-HDL-C Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1097/MD.0000000000049980 https://heart.lihaiyang.com/?p=detail&id=8550 INTRODUCTION: An affordable heart-healthy dietary approach is essential for the management of familial hypercholesterolaemia (FH); however, the optimal dietary pattern and the role of adjunctive nutrient supplementation remain uncertain. This study aims to evaluate the effects of the Brazilian Cardi Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1136/bmjopen-2026-119951 https://heart.lihaiyang.com/?p=detail&id=33894 Evidence from clinical trials indicates that dietary protein plays an important and often underappreciated role in lipoprotein lipid metabolism. For this narrative review, literature searches were conducted in the PubMed and Cochrane Central Register of Controlled Trials databases for articles descr Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18132207 https://heart.lihaiyang.com/?p=detail&id=8552 Background/Objectives: The safety of specific parenteral glucose intake values within the range currently recommended by international guidelines for the early acute phase in preterm neonates has not been established. This study aimed to evaluate whether exceeding a data-driven parenteral dextrose i Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18111821 https://heart.lihaiyang.com/?p=detail&id=33897 Background: Perilla seed oil (PSO) is a high-nutritional-value oil and widely used in functional foods, and derives from the mature seeds of Perilla frutescens. This study aimed to systematically evaluate the nutritional characteristics and safety of PSO, as well as to investigate its lipid-modulati Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.3390/nu18132149 https://heart.lihaiyang.com/?p=detail&id=8554 AIMS: The purpose of this paper is to compare the risk of incident type 2 diabetes mellitus (T2DM) among patients with hyperlipidaemia treated with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors versus statins and other nonstatin lipid-lowering agents. METHODS AND RESULTS: This tar Mon, 30 Nov -001 00:00:00 +0805 血脂 https://doi.org/10.1002/dmrr.70188