https://heart.lihaiyang.com 心血管文献检索平台 - 最新收录论文 zh-CN https://heart.lihaiyang.com/?p=detail&id=189 Environmental pollution - including air, noise, and light - and progressive climate change are major contributors to global health burdens, responsible for over 9 million premature deaths annuallysa. Among environmental exposures, air and noise pollution show the strongest epidemiological links to h Fri, 20 Mar 2026 00:00:00 +0800 高血压 https://doi.org/10.1093/cvr/cvag061 https://heart.lihaiyang.com/?p=detail&id=181 高血压是心血管疾病、卒中、慢性肾病和过早死亡的首要可改变危险因素。虽然血管紧张素原是肾素-血管紧张素-醛固酮系统的核心组成部分，但历史上主要将其视为生化底物而非血压的主动调节因子，与血管紧张素转换酶和血管紧张素II受体等下游成分相比，作为治疗靶点的关注度较低。然而，新出现的证据突出了其在血压调节中的动态、组织特异性作用及其对代谢、激素和炎症刺激的应答。本综述检查了血管紧张素原的分子生物学、结构-功能关系和调节机制，包括M235T和-6G>A等遗传变异对个体和群体水平高血压易感性的贡献。进一步探讨了血管紧张素原在盐敏感性高血压、肥胖相关炎症和肾素-血管紧张素-醛固酮系统逃逸现象中的致病作用。最近 Thu, 19 Mar 2026 00:00:00 +0800 高血压 https://doi.org/10.1161/HYPERTENSIONAHA.125.26091 https://heart.lihaiyang.com/?p=detail&id=28 To re-analyse the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) trial using the win ratio approach to better understand the relative contributions of individual outcomes in a composite endpoint. We applied an unmatched win ratio anal Thu, 01 Jan 2026 00:00:00 +0800 高血压 https://doi.org/10.1093/ehjcvp/pvag026 https://heart.lihaiyang.com/?p=detail&id=50 To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean ar Thu, 01 Jan 2026 00:00:00 +0800 高血压 https://doi.org/10.1093/eurheartj/ehag313 https://heart.lihaiyang.com/?p=detail&id=124 Although long-term exposure to fine particulate matter (particles ≤ 2.5 μm in diameter [PM2.5]) has been linked to adverse cardiovascular outcomes, evidence remains limited regarding the effects of PM2.5 at concentrations below current regulatory standards on hypertension-related hospitalization. In Thu, 01 Jan 2026 00:00:00 +0800 高血压 https://doi.org/10.1016/j.jacc.2026.02.5112 https://heart.lihaiyang.com/?p=detail&id=128 Addressing the rising burden of stroke in low-income countries will require pragmatic and scalable interventions targeting major risk factors. Under routine care settings, <10% of adults living with hypertension ever achieve blood pressure control, accentuating risks for adverse vascular events. The Thu, 01 Jan 2026 00:00:00 +0800 高血压 https://doi.org/10.1161/CIRCULATIONAHA.125.077424 https://heart.lihaiyang.com/?p=detail&id=33792 OBJECTIVE: Hyponatremia is one of the most common electrolyte disorders in clinical practice and is frequently observed following thiazide use. Advanced age and female gender are implicated in the etiology of hydrochlorothiazide (HCTZ)-associated hyponatremia. There has also recently been mention of Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1080/10641963.2026.2702343 https://heart.lihaiyang.com/?p=detail&id=40192 OBJECTIVE: To examine the association between mental health service (MHS) utilization and diabetes-hypertension (DM-HTN) comorbidity and to explore the roles of depression, health behaviors, and subgroup heterogeneity in this association. METHODS: Data were obtained from a community-based cross-sect Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3389/fpubh.2026.1835225 https://heart.lihaiyang.com/?p=detail&id=46592 BACKGROUND: There has been an increase in the prevalence of erectile dysfunction (ED) in the general population especially among hypertensive patients. This seems to be neglected problem in low-income countries especially our environment with huge attendance consequences. Measures to address the ris Mon, 30 Nov -001 00:00:00 +0805 高血压 https://heart.lihaiyang.com/?p=detail&id=46592 https://heart.lihaiyang.com/?p=detail&id=33793 PURPOSE: To compare the effects of captopril and losartan on inflammatory response, angiogenesis, and fibroblast activity during the early phase of wound healing in hypertensive rats. METHODS: Twenty-seven paraffin-embedded skin wound samples from hypertensive rats were analyzed: control group (n = Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1590/acb413126 https://heart.lihaiyang.com/?p=detail&id=40193 IMPORTANCE: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely prescribed antihypertensive agents. Although their cardiovascular and renal benefits are well established, uncertainty remains regarding their long-term associations with cancer risk. OBJ Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1371/journal.pone.0354248 https://heart.lihaiyang.com/?p=detail&id=46593 Hypertension is a prevalent disease globally and its prevalence is rising in sub-Saharan Africa. Urban-rural differences in the prevalence of hypertension are under-reported in Nigeria. Though hypertension is known to be related to obesity, the nature of the relationship is still unclear. This study Mon, 30 Nov -001 00:00:00 +0805 高血压 https://heart.lihaiyang.com/?p=detail&id=46593 https://heart.lihaiyang.com/?p=detail&id=8450 An initial presentation of severe chest or back pain with uncontrolled hypertension in the absence of cardiac etiology is synonymous with aortic dissection. For aortic dissections that do not involve the ascending aorta, malperfusion, or rupture, initial treatment with blood pressure management is f Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1053/j.semvascsurg.2026.03.009 https://heart.lihaiyang.com/?p=detail&id=40194 BACKGROUND: The burden of hypertension (HTN), type 2 diabetes mellitus (DM), and obesity is increasing among employees, driven by workplace-related factors such as sedentary behavior and unhealthy lifestyles, while follow-up management after health checkups remains inadequate. Mobile health (mHealth Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.2196/82822 https://heart.lihaiyang.com/?p=detail&id=46594 BACKGROUND: As an established driver of hypertension, obstructive sleep apnea (OSA) generates a significant cardiovascular burden when both disorders are present. This intersection not only compromises nocturnal hemodynamics but also hampers long-term clinical management. Yet, current health care de Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.2196/84506 https://heart.lihaiyang.com/?p=detail&id=8451 BACKGROUND AND OBJECTIVES: The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing these differences. We aimed to estimate the extent to which controlling for hypertension mediates racia Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1212/WNL.0000000000218164 https://heart.lihaiyang.com/?p=detail&id=33795 Objective: To explore the association between cumulative blood pressure load from childhood to midlife and the risk of arteriosclerosis in midlife. Methods: This study was based on the Hanzhong Children's Hypertension Cohort in Shaanxi Province. Using 36-year longitudinal follow-up data of 4 623 chi Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3760/cma.j.cn112148-20251210-00866 https://heart.lihaiyang.com/?p=detail&id=46595 OBJETIVO: Describir el proceso de desarrollo y las características principales de los Protocolos Nacionales de Atención Médica (PRONAM), una estrategia nacional para estandarizar la práctica clínica en el primer nivel de atención en México. Material y métodos. Proceso metodológico liderado por el Co Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.21149/18220 https://heart.lihaiyang.com/?p=detail&id=8452 UNLABELLED: Cardiovascular disease is the leading cause of mortality in pediatric patients with chronic kidney disease (CKD). In the general pediatric population, hypertension is associated with an increased risk of left ventricular hypertrophy (LVH); however, the strength of this association varies Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1007/s00431-026-07153-5 https://heart.lihaiyang.com/?p=detail&id=46596 BACKGROUND: Traditional ABG is susceptible to interference from acute stress and daily fluctuations, making it difficult to accurately assess true acute blood glucose surges. To bridge this gap, we adopted the Stress Hyperglycemia Ratio (SHR), which reflects true acute hyperglycemia by controlling f Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1371/journal.pone.0352162 https://heart.lihaiyang.com/?p=detail&id=33797 Background: Systemic arterial hypertension (SAH) induced by Nω-nitro-L-arginine methyl ester (L-NAME) is a well-established model characterized by nitric oxide (NO●) synthase inhibition and vascular dysfunction. The transient receptor potential vanilloid 1 (TRPV1) regulates Ca2+ flux and may contrib Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3390/molecules31132212 https://heart.lihaiyang.com/?p=detail&id=8454 BACKGROUND: Medication non-adherence remains a major barrier to effective chronic disease management, particularly in low- and middle-income countries. In Ghana, limited access to continuous care and patient engagement tools contributes to poor adherence among individuals living with type 2 diabetes Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.7189/jogh.16.04203 https://heart.lihaiyang.com/?p=detail&id=8455 Hypertension is a major global health issue, and continuous, convenient blood pressure monitoring is of great significance for early screening and intervention. To address the insufficient exploitation of multi-scale temporal features and the high model complexity in existing radar-based non-contact Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3390/s26113468 https://heart.lihaiyang.com/?p=detail&id=8456 Pulmonary arterial hypertension (PAH) is a chronic and progressive cardiopulmonary vascular disorder associated with poor clinical prognosis. Its hallmark pathological feature is sustained elevation of pulmonary vascular resistance resulting from extensive vascular remodeling. Endothelial-to-mesench Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3390/ijms27114951 https://heart.lihaiyang.com/?p=detail&id=33800 Proton pump inhibitors (PPIs) are widely prescribed for acid-related disorders and are generally considered safe for short-term use. However, increasing experimental and clinical evidence suggests potential cardiovascular effects associated with chronic exposure, possibly related to endothelial dysf Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3390/ijms27135913 https://heart.lihaiyang.com/?p=detail&id=41992 We performed a post hoc exploratory secondary analysis to investigate whether baseline circadian blood pressure (BP) pattern was associated with changes in serum uric acid (SUA) during 8-week antihypertensive therapy. Of the 494 hypertensive patients who received amlodipine (5-10 mg) or nifedipine G Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1111/jch.70324 https://heart.lihaiyang.com/?p=detail&id=8458 Congenital diaphragmatic hernia (CDH) is a complex neonatal condition characterized by pulmonary hypoplasia and pulmonary hypertension, requiring specialized ventilatory management from birth through postoperative care. This article synthesizes the current evidences and evolving strategies for optim Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1016/j.clp.2026.02.002 https://heart.lihaiyang.com/?p=detail&id=8459 OBJECTIVE: Insulin resistance (IR) is central to cardiometabolic risk in obesity, but the clinical utility of IR indices may vary by age. We compared homeostasis model assessment for insulin resistance (HOMA-IR) and metabolic score for insulin resistance (METS-IR) across age groups in obese adults a Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.20945/2359-4292-2026-0059 https://heart.lihaiyang.com/?p=detail&id=33803 Mango (Mangifera indica L.) pulp contains bioactive compounds with potential therapeutic effects against metabolic and immune-related disorders. However, the integrated effects of mango pulp extract on metabolic, cardiovascular, and immunomodulatory functions remain insufficiently characterized. The Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3390/ijms27135742 https://heart.lihaiyang.com/?p=detail&id=8460 IntroductionHypertension remains a major public health concern in Tanzania, yet evidence on the combined adoption of healthy lifestyle behaviors across rural and urban populations remains limited. This study assessed healthy lifestyle adoption and associated socio-demographic factors among adults in Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1177/00469580261460386 https://heart.lihaiyang.com/?p=detail&id=33804 The implementation of different hypertension thresholds (e.g. ESC/ESH: 140:90 or ACC/AHH: 130:80) substantially increased hypertension prevalence donation of pharmacological treatment across various populations. Under narrow margins of only 10mmHg, measurement accuracy and reliability become decisiv Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1186/s12872-026-06262-1 https://heart.lihaiyang.com/?p=detail&id=8461 INTRODUCTION: We evaluated associations between phosphorylated au 217 (p-tau217), p-tau181, p-tau231, and vascular risk factors with cognitive outcomes across the Alzheimer's disease (AD) continuum. METHODS: Baseline plasma p-tau concentrations and vascular risk factors were assessed in 277 Consorti Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1002/alz.71588 https://heart.lihaiyang.com/?p=detail&id=15630 OBJECTIVES: To identify risk factors and examine associations between colorectal cancer (CRC) status and modifiable and non-modifiable risk factors among patients diagnosed in Oman, considering the existence and increase of incidence and prevalence of these risk factors. DESIGN: A multicentre case-c Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1136/bmjopen-2026-117673 https://heart.lihaiyang.com/?p=detail&id=24590 OBJECTIVE: To evaluate the effectiveness of an intensive community-based smoking cessation intervention on smoking behavior and blood pressure control among patients with hypertension. METHODS: A cluster randomized controlled trial was conducted from June to September 2024 in primary healthcare inst Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.03.010 https://heart.lihaiyang.com/?p=detail&id=33806 BACKGROUND: Endothelial dysfunction and arterial stiffness are key underlying mechanisms that contribute to erectile dysfunction (ED), a common and often underdiagnosed condition among men with hypertension. Furthermore, certain classes of antihypertensive medications may adversely affect erectile f Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1093/sxmrev/qeag046 https://heart.lihaiyang.com/?p=detail&id=18191 Gut microbiota and bile acids are increasingly recognized to regulate blood pressure, but the mechanisms remain unclear. Takeda G-protein coupled receptor 5 (TGR5) is a major receptor for secondary bile acids. We hypothesized that loss of TGR5 function remodels gut microbiota and influences blood pr Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1080/19490976.2026.2691346 https://heart.lihaiyang.com/?p=detail&id=24591 OBJECTIVE: To characterize the longitudinal trajectories of body-mass-index-for-age Z-score(BAZ) from birth to 7-9 years and to explore their association with elevated blood pressure(EBP) in childhood. METHODS: Based on the TAWS prospective cohort study in China, children living in Taicang were foll Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.19813/j.cnki.weishengyanjiu.2026.03.008 https://heart.lihaiyang.com/?p=detail&id=8464 Both hypertensive and breast diseases impose a significant societal burden. However, the correlation between antihypertensive drug use and breast cancer remains controversial. We aimed to determine their potential correlations and explore their possible mechanisms. We performed summary data-based Me Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1097/MD.0000000000049141 https://heart.lihaiyang.com/?p=detail&id=24592 Patient empowerment remains a critical component in the management of non-communicable diseases, particularly in low-resource settings where health system constraints limit continuity of care. Diabetes and hypertension are increasingly prevalent in Rwanda, requiring sustained patient engagement and Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.3233/SHTI260897 https://heart.lihaiyang.com/?p=detail&id=37392 OBJECTIVE: Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular disease, particularly when hypertension coexists. However, evidence regarding the role of cardiac rehabilitation (CR) in this high-risk population remains limited. In this randomized controlled trial, the eff Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1111/1756-185x.70793 https://heart.lihaiyang.com/?p=detail&id=50192 Renin-angiotensin system (RAS) blockers, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are known to slow chronic kidney disease (CKD) progression in patients with established renal impairment. However, whether RAS blockade can prevent new-onset Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1080/0886022X.2026.2711459 https://heart.lihaiyang.com/?p=detail&id=30993 BACKGROUND: Jasmine oil massage has a thousand years of traditional history of curing and treating various ailments like hypertension, diabetes and muscle cramps without any sound pharmacological evidence. Traffic wardens have to stand throughout their duty hours, which can lead to muscle fatigue an Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.36721/PJPS.2026.39.9.253.1 https://heart.lihaiyang.com/?p=detail&id=37393 The role of the immune system in the development of hypertension is well-established. Recent studies revealed the critical role of G-protein-coupled receptor signaling, particularly angiotensin II (Ang II) type 1 receptor (AT1R), in immune cell function. Regulator of G-protein signaling (RGS) protei Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.14814/phy2.71023 https://heart.lihaiyang.com/?p=detail&id=50193 Health care systems have a key role in improving hypertension control in large populations, a global challenge, through the implementation of modern multicomponent programs. The impact of such programs in at-risk minority populations, nonetheless, remains to be better characterized. Additionally, th Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1111/jch.70297 https://heart.lihaiyang.com/?p=detail&id=11030 This cross-sectional study aimed to examine the associations between total intake of 3 B vitamins (thiamin, riboflavin, niacin) and hypertension and increased pulse pressure in U.S. adults, and to explore potential nonlinear relationships.Data from the U.S. National Health and Nutrition Examination Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1097/MD.0000000000049149 https://heart.lihaiyang.com/?p=detail&id=5655 PURPOSE: To extend the Chronic Hypertension and Pregnancy (CHAP) trial findings, this study compared labetalol, nifedipine, and methyldopa initiation at or before 23 weeks' gestation in pregnant patients with chronic hypertension, examining effects on a composite effectiveness outcome and on small f Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1002/pds.70406 https://heart.lihaiyang.com/?p=detail&id=11032 BACKGROUND: Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwide. Electroacupuncture (EA), combining traditional acupuncture with pulsed electrical stimulation at specific acupoints, has attracted growing attention as a potential a Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1080/10641963.2026.2685125 https://heart.lihaiyang.com/?p=detail&id=32792 Mental illness is a frequent comorbidity in chronic diseases including hypertension, yet integration of mental health screening into hypertension care remains limited, particularly in low- and middle-income countries. This systematic review synthesizes qualitative evidence on healthcare providers' e Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1093/heapro/daag090 https://heart.lihaiyang.com/?p=detail&id=39192 OBJECTIVES: We evaluated the association between chronic kidney disease and the current and background conditions of adults with spina bifida. METHODS: Patients with spina bifida (group A, n = 34) and patients with a history of pediatric encephalitis or spinal cord injury (group B, n = 23) who were Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1111/iju.70576 https://heart.lihaiyang.com/?p=detail&id=45592 ObjectiveHypertension is a common and modifiable cardiovascular risk factor. The triglyceride-total cholesterol-body weight index is a novel metabolic indicator derived from routine clinical measurements, but its association with hypertension remains unclear.MethodsThis longitudinal cohort study use Mon, 30 Nov -001 00:00:00 +0805 高血压 https://doi.org/10.1177/03000605261470980