Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.
📚 期刊: Circulation research
📅 发表: 0000-00-00
🔬 PMID: 41983287 👁️ 浏览: 13
👤 作者: Perry R Noah, Lenert Graham, Benavente Ernest Diez, Bölük Aydin, Hernandez Rebecca, Ma Lijiang, Barbera Nicolas, Watts Kelsey, Mendoza Victor D, Örd Tiit, Taipale Mari, Sachs Nadja, Pauli Jessica, Mokry Michal, de Kleijn Dominique P V, de Winther Menno P J, Mayr Manuel, Maegdefessel Lars, Reue Karen, Kaikkonen Minna U, Björkegren Johan L M, den Ruijter Hester M, Civelek Mete
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📝 摘要
Atherosclerosis, an inflammatory driver of coronary artery disease, manifests as unstable atheromatous plaques and stable fibrous plaques. Although atheromatous plaques have been extensively studied, fibrous plaques, particularly in women aged <50 years, where erosion contributes significantly to coronary thrombosis, remain less understood. The molecular mechanisms underlying sex differences in plaque biology, including vascular smooth muscle cell contributions, are incompletely defined.