The role of proteins in cellular activity has received close attention. Proteome analysis can detect early enough changes in the cell before the appearance of pathological changes. Due to the increasing number of cardiovascular complications, more specifically hypertension in modern life, this experimental pilot study tries to detect early changes in the protein profile in cases with arterial hypertension. In this pilot study, animal models were used, specifically control rats and spontaneously hypertensive rats (SHRs), which are widely used as translational models relevant to human cardiovascular physiology. Using gel electrophoresis (GE) method, we analysed proteomic signature of blood plasma and aorta tissue samples of the animal models.