👤 作者: Xie Tian, Ani Alireza, Vaez Ahmad, Nolte Ilja M, Su Shaoyong, Ishikuro Mami, Wang Siqi, Zhang Wenbo, Soares Ana Goncalves, Motazedi Ehsan, Calas Lucinda, Ronkainen Justiina, Pedersen Casper-Emil T, Lu Xueling, Stinson Sara E, Felix Janine F, Stankevic Evelina, Wang Carol A, Thiering Elisabeth, Fernández Dietmar, Calvo-Serra Beatriz, Stathopoulou Maria G, Fore Ruby, Kumar Ashish, Tuhkanen Johanna, Bilbao Jose Ramon, Ibarluzea Jesus, Isaacs Aaron, Fonvig Cilius Esmann, Rivadeneira Fernando, Lund Morten Asp Vonsild, Holm Louise Aas, van der Most Peter J, Riese Harriëtte, Narita Akira, Tamiya Gen, Flexeder Claudia, Wiersma Rikstje, Argoty-Pantoja Anna D, Vinding Rebecca, Hansen Tine Willum, Kümler Thomas, Estarlich Marisa, Bustamante Mariona, Yuan Wen Lun, Boland-Augé Anne, Deleuze Jean-François, Petrelis Alexandros M, Rifas-Shiman Sheryl, Kajantie Eero, Fernandez-Jimenez Nora, Santa-Marina Loreto, Arts Ilja C W, Lahti Jari, Strandberg Timo, Kull Inger, Bergström Anna, Hivert Marie-France, Bønnelykke Klaus, Kuriyama Shinichi, Beilin Lawrence J, Mori Trevor A, Hartman Catharina A, Grarup Niels, Thijs Carel, Räikkönen Katri, Melén Erik, Oken Emily, Visvikis-Siest Sophie, Gützkow Kristine B, Grazuleviciene Regina, Heude Barbara, Chatzi Leda, Vrijheid Martine, Standl Marie, Vrijkotte Tanja, Pennell Craig E, Oldehinkel Albertine J, Hansen Torben, Jaddoe Vincent W V, Holm Jens-Christian, Sebert Sylvain, Timpson Nicholas J, Obara Taku, Wang Xiaoling, Lawlor Deborah A, Corpeleijn Eva, Ahluwalia Tarunveer S, Snieder Harold
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Xie Tian, Ani Alireza, Vaez Ahmad, Nolte Ilja M, Su Shaoyong, Ishikuro Mami, Wang Siqi, Zhang Wenbo, Soares Ana Goncalves, Motazedi Ehsan, Calas Lucinda, Ronkainen Justiina, Pedersen Casper-Emil T, Lu Xueling, Stinson Sara E, Felix Janine F, Stankevic Evelina, Wang Carol A, Thiering Elisabeth, Fernández Dietmar, Calvo-Serra Beatriz, Stathopoulou Maria G, Fore Ruby, Kumar Ashish, Tuhkanen Johanna, Bilbao Jose Ramon, Ibarluzea Jesus, Isaacs Aaron, Fonvig Cilius Esmann, Rivadeneira Fernando, Lund Morten Asp Vonsild, Holm Louise Aas, van der Most Peter J, Riese Harriëtte, Narita Akira, Tamiya Gen, Flexeder Claudia, Wiersma Rikstje, Argoty-Pantoja Anna D, Vinding Rebecca, Hansen Tine Willum, Kümler Thomas, Estarlich Marisa, Bustamante Mariona, Yuan Wen Lun, Boland-Augé Anne, Deleuze Jean-François, Petrelis Alexandros M, Rifas-Shiman Sheryl, Kajantie Eero, Fernandez-Jimenez Nora, Santa-Marina Loreto, Arts Ilja C W, Lahti Jari, Strandberg Timo, Kull Inger, Bergström Anna, Hivert Marie-France, Bønnelykke Klaus, Kuriyama Shinichi, Beilin Lawrence J, Mori Trevor A, Hartman Catharina A, Grarup Niels, Thijs Carel, Räikkönen Katri, Melén Erik, Oken Emily, Visvikis-Siest Sophie, Gützkow Kristine B, Grazuleviciene Regina, Heude Barbara, Chatzi Leda, Vrijheid Martine, Standl Marie, Vrijkotte Tanja, Pennell Craig E, Oldehinkel Albertine J, Hansen Torben, Jaddoe Vincent W V, Holm Jens-Christian, Sebert Sylvain, Timpson Nicholas J, Obara Taku, Wang Xiaoling, Lawlor Deborah A, Corpeleijn Eva, Ahluwalia Tarunveer S, Snieder Harold (2026). Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.. Eur Heart J. https://doi.org/10.1093/eurheartj/ehag313
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📝 摘要
To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (n = 28 425) and HR (n = 22 565) were conducted in children of European ancestry aged 4-17 years. Follow-up analyses included comparisons with adult GWAS results, polygenic risk score (PRS) analyses in independent cohorts of diverse ancestries, and a phenome-wide association study in the UK Biobank. Eight genome-wide significant loci were identified for childhood BP (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2) and three loci for childhood HR (CCDC141, ACHE, MYH6); all novel in children but previously reported in adults. Childhood PRSs explained up to 1.6% of BP variance and 5.2% of HR variance among children of European ancestry. Genetic correlations between childhood and adulthood BP traits were moderate (rg = 0.4-0.7), suggesting age-specific genetic effects on BP. In the UK Biobank, higher childhood BP PRS levels were significantly associated with a broad range of adult health outcomes, particularly cardiometabolic outcomes such as hypertension, angina, myocardial infarction, and cardiovascular disease-related mortality. These findings advance the understanding of the genetic architecture of childhood BP and HR and provide compelling genetic evidence linking childhood BP to a broad spectrum of adult health outcomes-particularly cardiometabolic conditions-which may inform targeted prevention strategies from a young age.