Pathophysiological mechanisms and therapeutic potential of E-selectin in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a life-threatening pulmonary vascular disease characterized by progressive obstructive remodeling of the small pulmonary arteries. Its pathophysiological core ...
Severe Trileaflet Aortic Stenosis Without Significant Valve Calcification in an Older Adult.
Severe aortic stenosis (AS) is most often caused by progressive valve calcification; however, rare cases occur with little or no calcification. We report a 79-year-old man with a trileaflet aortic val...
Surgical Reconstruction of a Suprahepatic Inferior Vena Cava Aneurysm Using a Tubularized Bovine Pericardial Patch.
Inferior vena cava (IVC) aneurysms are rare clinical entities with fewer than 80 cases reported in the literature. Type I aneurysms involving the suprahepatic IVC present significant surgical challeng...
Niacin alleviates cerebral microvascular endothelial cell apoptosis induced by hypervirulent Klebsiella Pneumoniae by reducing the accumulation of reactive oxygen species.
INTRODUCTION: Hypervirulent Klebsiella pneumoniae (hvKp) is an important pathogen causing central nervous system infections, including meningitis; however, the mechanisms by which it disrupts the bloo...
Clinical outcomes of injectable and conventional pulmonary valve replacement in severe pulmonary regurgitation.
BACKGROUND/AIM: Pulmonary regurgitation following tetralogy of Fallot repair is a common long-term complication requiring pulmonary valve replacement. Injectable bioprosthetic valves offer a less inva...
Common femoral vein wall thickness as a supportive imaging marker in the differential diagnosis of Behçet's uveitis.
BACKGROUND/AIM: Ocular involvement is a major cause of morbidity in Behçet's disease (BD), and its diagnosis may be challenging, particularly for patients with isolated ocular manifestations or incomp...
Improving performance of polygenic risk scores for hypertension across two ancestry groups.
Polygenic risk score (PRS) methods are evolving, and the benefit of adding functional annotations to the variant weights has been especially promising. However, less attention has been given to how th...
Long noncoding RNA Gpr137b-ps mediates 15-PGDH-induced angiogenesis in brain microvasculature following tMCAO in mice.
BACKGROUND: Angiogenesis is essential for recovery following ischemic stroke, as brain microvascular endothelial cells (BMVECs) drive vascular repair. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) i...
Pharmacovigilance Evaluation of Noninfectious Myocarditis and Pericarditis in Immune Checkpoint Inhibitor Recipients Using FAERS.
IntroductionImmune-related adverse events (irAEs) pose considerable challenges to the clinical application of immune-checkpoint inhibitors (ICIs). Noninfectious myocarditis/pericarditis is a class of ...
PANoptosis links gut dysbiosis to obstructive sleep apnea-associated atherosclerosis: a gut-vascular inflammatory axis.
Obstructive sleep apnea (OSA) is increasingly recognized as an independent contributor to atherosclerotic cardiovascular disease, yet the mechanisms linking nocturnal intermittent hypoxia (IH) to plaq...
Adherence to medication and gender are associated with uncontrolled hypertension: findings of a cross-sectional study in East-Central Uganda.
INTRODUCTION: while uncontrolled hypertension (UCH) affects mostly developing countries, there is limited information on its burden and associated factors in Uganda. This study, therefore, sought to d...
Association between neutrophil percentage-to-albumin ratio and adverse clinical outcomes after successful percutaneous coronary intervention for chronic total occlusion: a cohort study.
BACKGROUND: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has improved outcomes, yet residual cardiovascular risk persists. The neutrophil percentage-to-albumin ratio (NPAR), ...
Acute pancreatitis during pregnancy: maternal and fetal outcomes in a five-case series.
Pregnancy-related acute pancreatitis (AP) is an uncommon but potentially life-threatening condition for both the mother and the fetus. The most frequent causes are biliary lithiasis and hypertriglycer...
Cardiomyopathy in women with acromegaly: clinical characteristics and associated factors in a Colombian multicenter registry.
BACKGROUND: Acromegalic heart disease (AHD) is a common complication of acromegaly; however, evidence specifically focused on women in Latin America remains limited. OBJECTIVE: To characterize cardiom...
Digital health information-seeking behaviors and trust in AI-based physician chatbots among patients with hypertension: a cross-sectional survey in Saudi Arabia.
BACKGROUND: Hypertension requires sustained self-management beyond routine clinical encounters, yet evidence on how patients engage with digital health information and what shapes their trust in AI-ba...
Prehypertension, Hypertension, and Their Association With Weight-Adjusted Waist Index in Normoglycemic Japanese Adults: A Cross-Sectional Study.
OBJECTIVE: Obesity, impaired glucose tolerance, and diabetes significantly increase hypertension risk. Previous studies across various populations have linked the weight-adjusted waist index (WWI)-a k...
Association between the C-reactive protein-triglyceride glucose index and coronary collateral circulation in patients with chronic total occlusion: a retrospective study.
OBJECTIVE: To examine the association between the C-reactive protein-triglyceride glucose (CTI) index and coronary collateral circulation (CCC) in patients with chronic total occlusion (CTO), and to a...
Single-point insulin sensitivity estimator and left main and/or three-vessel disease in patients aged 45 years or older with acute coronary syndrome: findings from the CCC-ACS project.
BACKGROUND: Severe coronary anatomical involvement is clinically important in patients with acute coronary syndrome (ACS), yet evidence on its relationship with insulin sensitivity remains limited. Th...
Changes in retinal venous diameter in proliferative diabetic retinopathy patients with diabetic macular edema following faricimab treatment: an observational study.
INTRODUCTION: To evaluate the effect of intravitreal faricimab injections on retinal venous diameter in proliferative diabetic retinopathy (PDR) patients with diabetic macular edema (DME). METHODS: Th...
Uncommon course of the common palmar digital artery of the fourth web space beneath the deep transverse metacarpal ligament: a cadaveric case report.
BACKGROUND: Anatomical variations of the palmar digital arteries are reported less frequently than variations of the superficial and deep palmar arches, particularly regarding their precise topographi...