Extracellular vesicle signalling in perioperative neurocognitive disorders.

Perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorder, are important complications in older and vul...

Microglia-vascular interactions after spinal cord injury: regulatory mechanisms and therapeutic advances.

The repair process following spinal cord injury (SCI) involves intricate crosstalk between neuroimmune and vascular systems, with microglia-vascular interactions increasingly recognized as an importan...

Engineering Nanocarriers for Dopamine Stabilization and Targeted Brain Delivery: Mechanisms, Approaches and Translational Challenges.

Dopamine plays a central role in motor control, cognition, reward signaling, and neuroendocrine regulation, and its dysregulation is strongly associated with neurological disorders such as Parkinson's...

Development and usability evaluation of HOPE: A patient-centered mHealth application for HTN self-management in Iran.

BACKGROUND: Hypertension (HTN) is a major global health problem and a significant risk factor for cardiovascular disease. Mobile health (mHealth) applications offer an efficient, patient-centered appr...

Factors related to the risk of developing chronic kidney disease in resistant hypertensive patients: a cross-sectional study.

OBJECTIVES: to analyze factors related to the risk of developing chronic kidney disease using the SCORED questionnaire in resistant hypertensive individuals. METHODS: this cross-sectional study was co...

Diagnosis of pulmonary arterial hypertension: a statement from the Brazilian Thoracic Association.

Pulmonary arterial hypertension (PAH) is a condition that predominantly affects the pulmonary arterial bed, leading to pulmonary vascular remodeling, progressive decrease in pulmonary arterial complia...

Robotic surgery for median arcuate ligament syndrome: technical aspects and imaging correlation.

BACKGROUND: Median arcuate ligament syndrome (MALS) is an uncommon condition characterized by chronic and intermittent abdominal pain, typically postprandial, and weight loss, caused by extrinsic comp...

The relationship between in-hospital mortality and Naples prognostic score in patients undergoing tricuspid valve surgery.

OBJECTIVE: Predicting in-hospital mortality rates following tricuspid valve surgery is imperative, especially in light of the recent advancements in treatment modalities. The Naples prognostic score s...

Clinical impact of the angiosome concept: is it applicable in femoropopliteal bypasses, limb salvage, and wound healing in critical pathologic limb-threatening ischemia?

INTRODUCTION: The global burden of peripheral artery disease is increasing worldwide. A subset of 5% of these patients ultimately reach the final stage with trophic defects, a condition clinically def...

Association between TyG index, TG/HDL-C ratio and coronary heart disease risk in elderly postmenopausal women: a retrospective cohort study.

OBJECTIVE: This study aimed to explore the importance of the triglyceride-glucose (TyG) index and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio in predicting the risk of coronar...

The first 24-h negative fluid balance is related to lower short-term mortality but higher AKI progression in critically ill heart failure: a retrospective cohort study.

BACKGROUND: Current guidelines lack instruction on fluid administration for patients with critically ill heart failure (HF) in the intensive care unit. OBJECTIVES: This study aims to compare the risk ...

Association Between Sleep Disorders and Adverse Cardiovascular Outcomes in Patients with Chronic Obstructive Pulmonary Disease: Insights from the UK Biobank.

BACKGROUND AND OBJECTIVE: A potential association between sleep disturbances and adverse cardiovascular prognoses has been proposed in patients with chronic obstructive pulmonary disease (COPD), altho...

Endothelial barrier disorder in hereditary angioedema: molecular mechanisms and therapeutic implications.

Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of vascular leakage and tissue swelling. Although excessive bradykinin generation has long been considered th...

Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p.

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) presents a significant challenge to the effectiveness of reperfusion therapy in severe ischemic heart disease. One of the core pathological me...

The influence of lean and fat mass on vascular structure and function in youth of varying body mass index percentiles- a comprehensive approach.

OBJECTIVE: The aim of this study was to compare and evaluate the relationship between body composition and arterial function among youth throughout a range of body mass index (BMI) percentiles. METHOD...

The Prognostic Value of Different Patterns of Neoatherosclerosis and Treatment Modality in Patients With Coronary In-Stent Restenosis.

BACKGROUND: Neoatherosclerosis (NA) and treatment modality may influence outcomes in patients with in-stent restenosis (ISR). This study evaluated the prognostic impact of different NA patterns and pe...

Understanding participants' experiences of a behaviour change intervention within cardiac rehabilitation: A nested process evaluation within the STRENGTH randomised controlled trial.

BACKGROUND: The STRENGTH (Self-management and Theory-based Rehabilitation Encouraging New Gateways to Healthy-Hearts) study evaluated a behaviour change intervention embedded within cardiac rehabilita...

IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.

Generating mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a major obstacle to accurate disease modeling and cardiac repair. As the transcription factor Irx3 is a...

Transcatheter and surgical aortic valve replacement for aortic stenosis in France: Trends from 2010 to 2022 and impact of European guidelines and clinical trial results.

BACKGROUND: The PARTNER trials played a key role in the expansion of transcatheter aortic valve replacement (TAVR) for severe aortic valve stenosis (AS), shaping international practice guidelines. We ...

Exploring the Other Side of Medication: A Patient Interview Study on Anti-PCSK9 Monoclonal Antibodies.

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors demonstrate significant lipid-lowering effects, but the widespread use of anti-PCSK9 monoclonal antibodies remains limited....