Reduced Retinal Perfusion With Preserved Microvascular Network Density in Early Alzheimer's Disease: A Multimodal Imaging Study.

PURPOSE: To characterize retinal neurovascular alterations in Alzheimer's disease (AD) and mild cognitive impairment (MCI) and examine structure-function relationships. METHODS: Eighty-two participant...

[Elderly patients with chronic limb-threatening ischemia: conservative treatment is appropriate care within an evolving healthcare landscape].

Revascularization remains the cornerstone of treatment for CLTI. Conservative treatment represents an underexposed yet potentially appropriate alternative for selected elderly and frail patients. This...

Care Navigation, Self-Measured Blood Pressure, and Health Coaching for Postpartum Care: A Randomized Clinical Trial.

IMPORTANCE: Hypertensive disorders of pregnancy (HDP) affect 10% to 16% of US pregnancies and increase the risk of developing cardiovascular disease. Guidelines recommend that individuals who experien...

[Endovascular treatment of iliofemoral venous thrombosis].

Endovenous procedures have been shown to offer an effective treatment for Iliofemoral deep venous thrombosis with a clinically relevant reduction in postthrombotic syndrome (PTS) compared to anticoagu...

Macular Choriocapillaris and Retinal Microvascular Alterations Across the Prediabetes-Early Type 2 Diabetes Continuum.

PURPOSE: To characterize macular microvascular alterations across the dysglycemia spectrum, from prediabetes (pre-DM) to early type 2 diabetes (T2DM), before clinically detectable diabetic retinopathy...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia.

IMPORTANCE: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. OBJECTIVE: To evaluate the co...

Impact of Continuous Positive Airway Pressure Treatment on Retinal Vasculature in Obstructive Sleep Apnea: A 7-Year Follow-Up.

PURPOSE: In previous studies, obstructive sleep apnea (OSA) severity at diagnosis was independently associated with retinal arteriolar narrowing and reduced retinal pulse amplitude. Participants with ...

Validation of a deep learning-based system for sleep staging, arousal detection, and respiratory event scoring in atrial fibrillation patients.

PURPOSE: Obstructive sleep apnea is a common yet underdiagnosed sleep disorder in patients with atrial fibrillation (AF). Although polysomnography (PSG) is the gold standard, its costs and complexity ...

Biomarkers of systemic disease burden and outcomes after transcatheter tricuspid edge-to-edge repair.

BACKGROUND: Risk stratification after transcatheter tricuspid edge-to-edge repair (T-TEER) remains challenging, particularly in patients with advanced right-sided heart failure and systemic disease bu...

Cerebrospinal fluid shunting or dural venous sinus stenting to preserve vision in idiopathic intracranial hypertension (IIH Intervention): protocol for an open-label, multicentre, randomised controlled phase IIb trial.

INTRODUCTION: Idiopathic intracranial hypertension (IIH) is characterised by raised intracranial pressure (ICP) and typically affects young women with obesity. Patients are at risk of permanent visual...

Antithrombotic strategy according to age in patients with atrial fibrillation and drug-eluting stents: a post hoc analysis of the ADAPT AF-DES randomised trial.

BACKGROUND: Evidence for non-vitamin K antagonist oral anticoagulant (NOAC) monotherapy for older patients with atrial fibrillation (AF) and drug-eluting stents is lacking. OBJECTIVES: We aimed to eva...

Hypertrophic cardiomyopathy-linked Tnnc1 variants are associated with distinct myopathic changes in slow skeletal muscle of mice.

Inherited hypertrophic cardiomyopathy (HCM) is considered a disease of the cardiac sarcomere and caused by pathogenic variants present in genes that encode sarcomeric proteins. The human TNNC1 gene is...

Time in tight range and time in range in relation to diabetic retinopathy and OCTA-derived retinal microvascular parameters in hospitalized adults with type 1 diabetes.

AIM: Time in Tight Range (TITR) is physiologically closer to normoglycemia than time in range (TIR) and has been linked to microvascular risk. We aimed to evaluate associations of TITR with diabetic r...

Endoplasmic reticulum stress is associated with cardiac effects of bisphenol S independently of a high-fat diet.

Obesity and endocrine disruptors (EDs) promote endoplasmic reticulum (ER) stress, a mechanism associated with cardiovascular diseases. Among EDs, BPS is widely used in consumer products. Whether BPS p...

Retinal and Choroidal Vascular Metrics Predict Cerebral Atrophy and Cognitive Impairment in Noninfarcted Large Artery Stenosis.

PURPOSE: Large artery stenosis (LAS) can drive cognitive impairment and neurodegeneration even without overt infarction, yet scalable biomarkers for capturing this silent vascular brain injury are lim...

Engineered Extracellular Vesicles As a New Delivery Platform for Migraine.

Migraine represents a complex neurovascular disorder that is challenging to treat due to the blood-brain barrier (BBB) and complex pathophysiology involving the trigeminovascular system, neuroinflamma...

Venous flaps to repaır the soft tıssue defects of the hand.

AIM: The venous flaps provide a versatile, easy flap choice to repair the dorsal skin defects of the fingers and web spaces. Its thin and pliable nature provides natural coverage for the important del...

Good cop, bad cop? Rethinking the roles of cardiac macrophages in injury.

Cardiac macrophages (CMs) preserve homeostasis in the heart by clearing cellular debris and facilitating electrical conduction. During tissue injury, embryonically derived CMs (em-CMs) have traditiona...

Lymphatic therapies open the valve in Marfan syndrome.

Myxomatous degeneration of the mitral valve (MDMV) is a common cardiovascular manifestation of Marfan syndrome (MFS), yet the role of lymphatic vessels in the disease progression remains unknown. In t...

Right ventricular-pulmonary artery uncoupling identifies higher risk of combined pulmonary hypertension in patients undergoing TAVR.

INTRODUCTION: Right ventricular-pulmonary artery (RV-PA) uncoupling, expressed as the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure (TAPSE/PAPs) ratio, is a negative pr...