A modality-agnostic coronary artery habitat model for cardiac sparing in radiotherapy.
BACKGROUND: Emerging evidence suggests that the risk of cardiotoxicity increases with increased radiation dose to coronary arteries (CAs). However, robust tools to evaluate this increased burden for c...
Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation.
Atherosclerosis (AS) is closely linked to endothelial cell (EC) senescence and mitochondrial dysfunction, which impair vascular repair. Resveratrol (RSV) has antioxidant, anti-inflammatory, and pro-an...
Atorvastatin Reduces Alcohol-Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol-Disulfide Imbalance in Rats.
Excessive alcohol consumption causes significant cardio-hepatic damage. This study investigated the effects of standard (10 mg/kg) and high (40 mg/kg) doses of atorvastatin on fibrosis, hypertrophy, a...
SRM 1650b Administration to Isolated Rat Heart Aggravates Ischemia-Reperfusion Injury via Mitochondrial Dysfunction and Downregulation of PI3K/Akt Signaling Pathways.
Numerous studies have demonstrated an association between diesel particulate matter (DPM) exposure and cardiotoxicity; recent evidence further suggests that cardiomyocytes may directly internalize DPM...
Genistein inhibits oxidative stress and alleviates vascular remodeling in hypertension through the GSK3β/FYN/Nrf2 pathway.
Hypertension raises cardiovascular risk via vascular remodeling, worsened by oxidative stress-linked VSMC dysfunction. Genistein (Gen), an antioxidant isoflavone, protects against cardiovascular disea...
Evaluation of the effect of Healing Touch on coronary artery bypass grafting recovery: A randomized controlled trial.
BACKGROUND: Healing Touch (HT) is used to provide holistic care, improve outcomes, and provide comfort. However, there is minimal published literature on its effects among inpatients undergoing corona...
Astrocyte coordinated remodelling of the dorsal horn endothelium and pain hypersensitivity.
Pain perception relies not only on sensory neurons but also on the interplay of a heterogeneous cell population, including endothelial cells, microglia, and astrocytes. Blood-spinal cord barrier dysfu...
Preliminary Validation of a Novel Genetic Knowledge Scale for Familial Hypercholesterolemia: Evaluation of Face Validity and Core Concepts.
Facilitating patient-informed decision making is central to the genetic counseling practice. The Multidimensional Model of Informed Choice (MMIC) evaluates informed decisions in genetic testing, but v...
Laparoscopic En Bloc Para-aortic Lymphadenectomy Up to the Renal Vein for Colorectal Cancer: How I Do It?
BACKGROUND: Primary tumor resection with simultaneous para-aortic lymph node dissection has curative potential in selected patients with isolated infrarenal para-aortic lymph node metastasis secondary...
Three-dimensional Mapping of Fibrosis Distribution in Desmoplakin Cardiomyopathy from Cardiac MRI.
Purpose To generate high-resolution fibrosis maps using universal ventricular coordinates for spatial characterization of fibrotic patterns across disease severity in desmoplakin cardiomyopathy. Mater...
Emerging Strategies for Cardio-Renal Protection Beyond RAAS Blockade: Emphasis on Non-diabetic CKD and Resistant Hypertension.
Non-diabetic chronic kidney disease (ND-CKD) complicated by resistant hypertension remains a high-risk phenotype even when renin-angiotensin system blockade is optimized. This review synthesizes conte...
Optimizing Antihypertensive Care for Tanzanians Living With HIV: Effectiveness Outcomes From the COACH Pilot Trial.
BACKGROUND: In Tanzania, many people living with HIV have uncontrolled hypertension, yet integration of hypertension management into HIV care remains limited. The Community Health Worker Optimization ...
Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction.
Acute myocardial infarction (MI) is the leading cause of heart failure (HF). However, the role of mitochondrial ROS (ROSm) in early MI dysfunction remains unclear. This study aimed to evaluate the imp...
Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion.
Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly in...
Vendor-independent Aortic Valve Calcium Scoring in Patients with Discordant Echocardiographic Criteria of Severe Aortic Stenosis.
Purpose To apply a vendor-neutral Agatston score (vnAS) for aortic valve calcification across multiple CT systems and to aortic stenosis severity classification. Materials and Methods Anthropomorphic ...
TRIM38 Alleviates Ferroptosis in Heart Failure by Inactivating the TRAF6-p38 MAPK Pathway via Ubiquitinating Degradation of IRAK1.
This article explored the role of TRIM38 in ferroptosis in heart failure (HF) and its underlying mechanisms. Methodologically, serum TRIM38, IRAK1 and TRAF6 proteins from HF patients were detected by ...
Model-based Differentiation Between Kawasaki Disease and MIS-C: The Importance of the Mitral Valve.
BACKGROUND: Due to increasing proportion of asymptomatic severe acute respiratory syndrome coronavirus 2 infections and previously reported overlapping features, the distinction between Kawasaki disea...
Post-Heart Transplantation Intensive Care Unit Recovery: A Phase-Based Approach.
Heart transplantation is the definitive treatment for end-stage heart failure. Post-transplant care is dynamic and complex, requiring a thoughtful multidisciplinary approach. Invasive hemodynamic moni...
Medical Management and Mechanical Circulatory Support Escalation in Right Ventricular Failure.
Right ventricular (RV) failure is a clinically distinct entity with significant prognostic implications across multiple cardiovascular conditions. Its diagnosis is challenging due to overlapping featu...
A Practical Guide to Intensive Care Unit Management after Left Ventricular Assist Device Implantation.
Durable left ventricular assist devices (LVADs) have transformed the management of advanced heart failure, but early post-operative management remains a time of heightened vulnerability with dispropor...