Spatiotemporal dynamics of blood coagulation in medium-sized vessels: numerical insights into the effects of vessel walls and blood flow.

The spatiotemporal distribution of coagulation factors fundamentally governs blood coagulation dynamics. Although these dynamics have been examined at the submillimeter scale (hundred micrometers), ho...

Transient Cardiac Dysfunction Due to New-Onset Mitral Chordal Rupture With Concomitant Congenital Absence of the Right Coronary Artery: A Case Report.

BACKGROUND Congenital absence of the right coronary artery (RCA) is a rare anomaly often identified incidentally. We report a case of transient left ventricular systolic dysfunction followed by recove...

Evolution of coronary artery bypass grafting: conventional, minimally invasive, robotic, and hybrid revascularisation techniques.

Coronary artery bypass grafting (CABG) remains one of the most durable treatments for obstructive coronary artery disease (CAD), particularly in anatomically complex multivessel disease, diabetes, lef...

A proposed technique for robotic port placement and arterial control of the femoral region for a peripheral arterial bypass with the Da Vinci SP system.

Robotic surgery has expanded minimally invasive options across several surgical specialties, yet adoption in peripheral vascular surgery remains limited. Groin incisions carry a high risk of wound inf...

Linguistic and Clinical Validation of the Polish Version of the Walking Impairment Questionnaire.

BACKGROUND: Intermittent claudication is one of the most common symptoms of peripheral arterial disease. The Walking Impairment Questionnaire (WIQ) is frequently used to assess patients suffering from...

Association of the triglyceride-glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus: mediation by myocardial energetic efficiency and resting perfusion.

BACKGROUND: The triglyceride-glucose(TyG) index, a surrogate marker of insulin resistance, has been linked to cardiac dysfunction; however, its underlying associated pathways in patients with type 2 d...

Pre-Capillary Pulmonary Hypertension in a Patient With Idiopathic Inflammatory Myopathy Without Extensive Pulmonary Involvement.

BACKGROUND Dermatomyositis is an idiopathic inflammatory myopathy (IIM) that presents commonly with cutaneous, myopathic, and systemic manifestations. Cardiopulmonary involvement is usually paired wit...

Glucagon-like Peptide-1 Receptor Agonists and Dual Incretin Therapies Across HFpEF and Cardiovascular Outcomes Trials in Patients with Obesity.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and emerging dual incretin therapies have demonstrated substantial effects on weight reduction and metabolic improvement, with growing evidence su...

Inflammation and Immune Mediators in the Context of Atherosclerotic Cardiovascular Disease and Percutaneous Coronary Intervention: Implications for Therapeutics.

Atherosclerotic cardiovascular disease (CVD) remains a leading cause of worldwide morbidity and mortality, despite well-established/effective pharmacological therapies. A substantial component of the ...

Arterial Stiffness in Patients with Obstructive Sleep Apnea and Hypertension: A Narrative Review.

Arterial stiffness is a determinant of cardiovascular risk and has been increasingly associated with obstructive sleep apnea (OSA), although its independent contribution remains unclear due to the pre...

Chrono-Nanomedicine at the Barrier: Circadian Rhythms Influence the Delivery of Donepezil Across the BCSFB.

To reach the target tissue within the central nervous system (CNS), drugs, such as donepezil (DNPZ), must overcome naturally occurring barriers. Despite its substantial pharmacological relevance, the ...

Exercise Modulates miR-276a/nej Expression and Function in the Drosophila Heart: A Possible Contribution of the Fat Body.

Cardiac rhythm and pumping function are essential outputs of cardiac homeostasis and depend on precise molecular regulation. The histone acetyltransferases CBP/p300 have been implicated in cardiac rem...

Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved.

Elevated plasma lipoprotein(a) [Lp(a)] levels represent a predominantly genetically determined risk factor for atherosclerotic cardiovascular disease and calcific aortic valve disease (CAVD). Mechanis...

Establishing Primary Cultures of Adult Mouse Cardiac Fibroblasts: A Comparative Evaluation of Three Experimental Protocols.

Cardiac fibroblasts (cFbs) are important in vitro models for studying myocardial fibrosis, extracellular matrix homeostasis, and tissue remodeling. However, establishing primary cultures from adult mo...

[Influences of hydroxylated recombinant human type III collagen on the functional characteristics of vascular smooth muscle cells].

This study was designed to investigate the effects of hydroxylated recombinant human type III collagen on the proliferation and migration of vascular smooth muscle cells (VSMCs). The viability of prim...

[Molecular mechanisms of enolase-mediated bacterial penetration of the blood-brain barrier].

Bacterial meningitis is associated with a high mortality and frequently leads to severe sequelae. Elucidating the molecular mechanisms underlying bacterial traversal of the blood-brain barrier (BBB) h...

[Morphology and anatomical variations of the left gastric vein].

Objective: To explore the gross morphology and variation characteristics of the left gastric vein (LGV) by means of cadaveric anatomical measurement and three-dimensional imaging reconstruction. Metho...

Rethinking Lipid Burden and the Role of Non-LDL Biomarkers in Stroke Risk Stratification.

PURPOSE OF REVIEW: This article reviews the existing literature on non-LDL biomarkers in atherosclerotic cardiovascular disease (ACSVD), atherogenesis, and ischemic stroke risk, including a discussion...

Interaction of a genetic sum score of risk alleles associated with coronary artery disease by physical activity in the Heinz Nixdorf Recall study.

OBJECTIVES: This study aimed to investigate the interaction between a genetic risk score for coronary artery disease (CAD) and measures of physical activity on coronary artery calcification (CAC) in a...

Pericardial migration of ventriculoperitoneal shunt: a case report with review of the literature.

BACKGROUND: Ventriculoperitoneal (VP) shunting is the standard surgical treatment for hydrocephalus, yet it is associated with a wide range of complications. Distal catheter migration into the pericar...