Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.
J, L.M., L, L., A, A., D, R., AM, A.G., C, R., L, T.S., M, F., MA, M.G., & V, S. (2026). Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.. Nutrients. https://doi.org/10.3390/nu18111669
J LM, L L, A A, D R, AM AG, C R, et al. Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.. Nutrients. 2026; doi: 10.3390/nu18111669
J LM, L L, A A, et al. Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.[J]. Nutrients. 2026. DOI: 10.3390/nu18111669.
@article{j2026,
author = {Lara Moreno J and Li L and Alonso A and Romaguera D and Alonso-Gómez AM and Razquin C and Tojal-Sierra L and Fiol M and Martinez-Gonzalez MA and Subramanya V},
title = {Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.},
journal = {Nutrients},
year = {2026},
doi = {10.3390/nu18111669},
note = {PMID: 42280313},
}
TY - JOUR AU - Lara Moreno J AU - Li L AU - Alonso A AU - Romaguera D AU - Alonso-Gómez AM AU - Razquin C AU - Tojal-Sierra L AU - Fiol M AU - Martinez-Gonzalez MA AU - Subramanya V TI - Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study. T2 - Nutrients PY - 2026 DO - 10.3390/nu18111669 AN - PMID:42280313 ER -
Background/Objectives: Whether habitual dietary omega-3 fatty acid intake is reflected in circulating biomarkers of atrial fibrillation (AF)-related pathways is unclear. We assessed whether usual dietary intake of n-3 fatty acids-considered as total, marine-derived, or non-marine-derived-was associated with the trajectories of five serum markers that reflect AF-related mechanistic pathways [N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (CRP), the C-terminal propeptide of type-I procollagen (PICP), and 3-nitrotyrosine (3-NT)] over 5 years of follow-up. Methods: In 510 participants of the PREDIMED-Plus trial (older Spanish adults with metabolic syndrome), we measured plasma NT-pro-BNP, hs-TnT, CRP, PICP, and 3-NT at baseline and after 3 and 5 years. Energy-adjusted omega-3 intake was assessed with a validated 143-item food-frequency questionnaire. Cross-sectional and 5-year longitudinal associations according to tertiles of omega-3 fatty acid intake were estimated with linear regression and mixed-effects models. Results: Median total omega-3 intake was 2.0 g/day. Total omega-3 intake was not associated with any biomarker, neither cross-sectionally nor longitudinally. Marine omega-3 was directly associated cross-sectionally with 3-NT (highest vs. lowest tertile +28.4%, 95% CI 5.5 to 56.2; p-trend = 0.014) but not longitudinally. Moderate baseline non-marine omega-3 fatty acid intake was associated with a decrease in PICP after 5 years of follow-up. Conclusions: Overall, habitual total omega-3 fatty acid intake was not associated with circulating AF-related pathways. The sporadic association between marine omega-3 fatty acid intake and 3-NT in the cross-sectional assessment and the isolated non-linear association between baseline non-marine omega-3 fatty acid intake and PICP after 5 years warrant further investigation.