Incidence and predictors of major arrhythmic events following acute myocarditis complicated by ventricular arrhythmias: a systematic review and meta-analysis.
Soundous, M., G, K.E., Moshe, R.A., Yuan, N.C., Piero, G., Marco, M., Gaetano, P., Lucas, D., Karim, B., Lucia, N.M., & Charles, G. (2026). Incidence and predictors of major arrhythmic events following acute myocarditis complicated by ventricular arrhythmias: a systematic review and meta-analysis.. Heart Rhythm. https://doi.org/10.1016/j.hrthm.2026.03.1952
Soundous M, G KE, Moshe RA, Yuan NC, Piero G, Marco M, et al. Incidence and predictors of major arrhythmic events following acute myocarditis complicated by ventricular arrhythmias: a systematic review and meta-analysis.. Heart Rhythm. 2026; doi: 10.1016/j.hrthm.2026.03.1952
Soundous M, G KE, Moshe RA, et al. Incidence and predictors of major arrhythmic events following acute myocarditis complicated by ventricular arrhythmias: a systematic review and meta-analysis.[J]. Heart Rhythm. 2026. DOI: 10.1016/j.hrthm.2026.03.1952.
@article{soundous2026,
author = {M'Rabet Soundous and Kaboré Elisé G and Rav-Acha Moshe and Ng Chee Yuan and Gentile Piero and Merlo Marco and Pinnacchio Gaetano and Deville Lucas and Benali Karim and Narducci Maria Lucia and Guenancia Charles},
title = {Incidence and predictors of major arrhythmic events following acute myocarditis complicated by ventricular arrhythmias: a systematic review and meta-analysis.},
journal = {Heart Rhythm},
year = {2026},
doi = {10.1016/j.hrthm.2026.03.1952},
note = {PMID: 41985646},
}
TY - JOUR AU - M'Rabet Soundous AU - Kaboré Elisé G AU - Rav-Acha Moshe AU - Ng Chee Yuan AU - Gentile Piero AU - Merlo Marco AU - Pinnacchio Gaetano AU - Deville Lucas AU - Benali Karim AU - Narducci Maria Lucia AU - Guenancia Charles TI - Incidence and predictors of major arrhythmic events following acute myocarditis complicated by ventricular arrhythmias: a systematic review and meta-analysis. T2 - Heart Rhythm PY - 2026 DO - 10.1016/j.hrthm.2026.03.1952 AN - PMID:41985646 ER -
Acute myocarditis (AM) complicated by ventricular arrhythmias (VA) carries an uncertain risk of VA recurrence after discharge. Predictors are poorly defined, complicating risk stratification and implantable cardioverter defibrillator (ICD) decision-making. To assess recurrence rates and identify predictors of major arrhythmic events (MAE) after AM complicated by sustained VA. This systematic review and meta-analysis was registered in PROSPERO (CRD420250594422). PubMed, Web of Science, and Cochrane Library were searched up to December 2024 for studies reporting post-discharge VA recurrence in patients with AM complicated by VA in the acute phase. Unpublished data were obtained from study authors to restrict analysis to sustained ventricular tachycardia (VT) and ventricular fibrillation (VF). The primary outcome was MAE at follow-up (documented sustained VA, appropriate ICD therapy or sudden cardiac death). Pooled recurrence rates and predictors were assessed using random-effects models. Eight observational studies (n=355) were analyzed. MAE occurred in 46.4% (95% CI 38.1-54.9; I2=50.0) during a mean pooled follow-up of 3.8 years (95% CI 2.7-5.1). Neither demographic factors (age, sex), comorbidities, cardiovascular risk factors nor ICD implantation prior to discharge were associated with MAE at follow-up. Reduced left ventricular ejection fraction and the presence or localization of late gadolinium enhancement on cardiac magnetic resonance were also not predictive. MAE recurrences after AM affect nearly half of patients with sustained VA during the acute phase. No consistent predictors emerged. These findings are consistent with the ESC guidelines and call for refined risk stratification from large, multicenter cohorts with standardized criteria.