Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis.
S, H., K, M., S, M., J, M., S, K., K, K., K, F., T, K., E, Y., & H, M. (2026). Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis.. Geriatrics & gerontology international. https://doi.org/10.1111/ggi.70597
S H, K M, S M, J M, S K, K K, et al. Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis.. Geriatrics & gerontology international. 2026; doi: 10.1111/ggi.70597
S H, K M, S M, et al. Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis.[J]. Geriatrics & gerontology international. 2026. DOI: 10.1111/ggi.70597.
@article{s2026,
author = {Hakozaki S and Matsumura K and Morishita S and Morimoto J and Kurose S and Kakehi K and Fujita K and Kawamura T and Yagi E and Matsuzoe H},
title = {Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis.},
journal = {Geriatrics & gerontology international},
year = {2026},
doi = {10.1111/ggi.70597},
note = {PMID: 42297732},
}
TY - JOUR AU - Hakozaki S AU - Matsumura K AU - Morishita S AU - Morimoto J AU - Kurose S AU - Kakehi K AU - Fujita K AU - Kawamura T AU - Yagi E AU - Matsuzoe H TI - Relationship Between Social Frailty and Sarcopenia and Its Impact on Long-Term Prognosis in Older Patients With Stage B Heart Failure: A PAPRIKA-HF Registry Subanalysis. T2 - Geriatrics & gerontology international PY - 2026 DO - 10.1111/ggi.70597 AN - PMID:42297732 ER -
AIM: To investigate the association between social frailty and sarcopenia and their combined effect on clinical outcomes in outpatients with stage B heart failure (HF). METHODS: This post hoc analysis of the PAPRIKA-HF study included 331 patients aged ≥ 65 years with stage B HF. Patients were stratified into three groups based on social frailty and sarcopenia. The primary outcome was a 2-year composite of all-cause death, myocardial infarction, and HF hospitalization. RESULTS: Of 308 patients, 189 (61%) had social frailty. Sarcopenia prevalence was higher in patients with versus without social frailty (20.6% vs. 11.8%, p = 0.04). Event rates for the composite outcome differed across groups (absence of social frailty and sarcopenia: 1.9% vs. presence of social frailty or sarcopenia: 3.0% vs. presence of both: 33.3%; log-rank p < 0.001). In the multivariable Cox model, no significant difference existed between absence of social frailty and sarcopenia and presence of social frailty or sarcopenia (hazard ratio 2.44; 95% confidence interval 0.51-11.52; p = 0.26), while presence of both had higher risk compared with absence of both (hazard ratio 12.98; 95% confidence interval 2.46-68.50; p < 0.01). CONCLUSION: The coexistence of social frailty and sarcopenia is associated with adverse outcomes in outpatients with stage B HF. Early identification and multidisciplinary interventions for social frailty may help improve long-term prognosis.