Cardiovascular-kidney-metabolic syndrome through the lens of gut‑derived uremic toxins.

Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a complex, interconnected cluster of cardiovascular disease, chronic kidney disease, and metabolic disorders such as obesity and type 2 diabet...

Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.

Heart and kidney diseases frequently coexist, but the genetic basis of this relationship remains unclear. We analyzed genetic data from large-scale studies to investigate how kidney function (estimate...

Pericardiectomy for constrictive pericarditis: short- and long-term outcomes in Sweden.

OBJECTIVES: Constrictive pericarditis can cause heart failure from restricted diastolic relaxation due to pericardial fibrosis. Pericardiectomy is the only curative treatment. However, evidence regard...

Combined podocyte, fibrotic and echocardiographic correlates of an operationally defined subclinical cardiorenal phenotype in chronic kidney disease: an exploratory study.

Although cardiovascular complications are the most common cause of morbidity and mortality in chronic kidney disease (CKD), the detection of subclinical cardiorenal remodeling is still limited. This i...

Evaluating and predicting of the cardiac function class and re-hospitalization in CHD with HF using IVC diameter and collapsibility index.

AIMS: Transthoracic echocardiography is widely used to assess the volume status of patients with coronary heart disease combined with heart failure (CHD-HF) because of its noninvasive and convenient n...

Postoperative outcomes of on- vs off-pump CABG in patients with HFrEF: a nationwide cohort study in Taiwan.

OBJECTIVE: The optimal surgical strategy for coronary artery bypass grafting (CABG) in patients with heart failure with reduced ejection fraction (HFrEF) is uncertain. This study aimed to compare post...

Clinical events and healthcare costs of dapagliflozin in adults with cardiovascular-kidney-metabolic syndrome in Spain: a cost-offset analysis.

AIMS: Adults with cardiovascular-kidney-metabolic (CKM) syndrome, characterized by interactions among metabolic, chronic kidney disease (CKD) and cardiovascular disease, face a high symptomatic burden...

Predicting major adverse cardiovascular and cerebrovascular events in chronic heart failure: a machine learning study.

BACKGROUND: Heart failure (HF) is a clinical syndrome characterized by impaired cardiac diastolic and systolic function due to structural or functional damage to the myocardium. HF represents the end-...

Clinical impact of an EHR-integrated hyperkalemia management system: a real-world study of 10,934 episodes.

This retrospective study analyzed 10,934 hyperkalemia episodes to compare outcomes between the hyperkalemia routine group and the hyperkalemia standardized group, the latter managed with a strategy su...

Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).

Periodontitis, a common oral disease, is increasingly recognized for its potential impact on systemic health, particularly its association with heart failure (HF). HF is a complex clinical syndrome wi...

Cardiac implantable electronic devices in heart failure: needs, challenges, and real-world implementation.

Cardiac implantable electronic devices (CIEDs) are integral to heart failure (HF) management, providing therapies for bradyarrhythmias, cardiac resynchronization therapy (CRT), sudden cardiac death (S...

Comparison of Guideline-Directed Medical Therapy in Black versus White Patients With Heart Failure With Reduced Ejection Fraction in a Large, Integrated Health Care System.

BACKGROUND: Guideline-directed medical therapy (GDMT) improves clinical outcomes for patients with heart failure with reduced ejection fraction (HFrEF). While GDMT treatment differences have been desc...

Risk of Heart Failure Hospitalization Associated With Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Versus Erythropoiesis-Stimulating Agents: A Nationwide Claims-Based Cohort Study.

PURPOSE: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are increasingly used to treat renal anemia in patients with chronic kidney disease (CKD). We evaluated the risk of heart fai...

The Cox-Aalen Rate Model for Recurrent Events With an Informative Terminal Event.

Recurrent event data arise frequently in many clinical and observational studies. In this article, we propose a Cox-Aalen rate model to analyze recurrent event data with a terminal event, where the co...

[Myocardial revascularization in patients with heart failure with reduced ejection fraction and ischemic heart disease].

Heart failure with reduced ejection fraction (HFrEF) of ischemic origin represents one of the leading causes of morbidity and mortality and is associated with a poor prognosis. Myocardial revasculariz...

[Feasibility and outcomes of a structured doctor-nurse follow-up program following hospitalization for myocardial infarction or heart failure: the Phase 1 of the DIMACC Project].

BACKGROUND: The year following hospitalization for acute myocardial infarction (AMI) or acute heart failure (AHF) is associated with a high risk of rehospitalization and death, often related to inadeq...

[The trajectory of several cardiovascular drugs: rise, decline, and new therapeutic perspectives].

Cardiovascular pharmacology over recent decades has been characterized by a dynamic and non-linear evolution, in which the introduction of new drugs has often been followed by progressive critical rea...

Does Intravenous Iron Improve Survival and Physical Function and Reduce Heart Failure Events in Patients with Chronic Kidney Disease?

AbstractIron deficiency is common in patients with chronic kidney disease (CKD). Contemporary guidelines recommend the use of iron therapy only in the presence of anemia. However, patients with CKD ar...

Gamified Cardiopulmonary Rehabilitation in a Child Undergoing LVAD Bridging Therapy to Heart Transplantation: A Case Report.

This report details the comprehensive, gamified cardiopulmonary rehabilitation of a 6-year-old girl undergoing a complex clinical journey from left ventricular assist device (LVAD) bridge therapy to s...

What Happened When a Heart Failure Unit Asked for Help with Its Culture?

Communication and teamwork are essential for providing safe and effective health care, particularly in light of increasingly complex health care teams comprising multiple disciplines. In late 2021, th...