Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.
G, A., G, C., D, M., M, D., G, S., C, F., A, P., P, P., F, A., & G, S. (2026). Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.. European journal of clinical investigation. https://doi.org/10.1111/eci.70237
G A, G C, D M, M D, G S, C F, et al. Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.. European journal of clinical investigation. 2026; doi: 10.1111/eci.70237
G A, G C, D M, et al. Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.[J]. European journal of clinical investigation. 2026. DOI: 10.1111/eci.70237.
@article{g2026,
author = {Armentaro G and Crudo G and Menichelli D and Daidone M and Severini G and Fuoco C and Panza A and Pignatelli P and Andreozzi F and Sesti G},
title = {Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.},
journal = {European journal of clinical investigation},
year = {2026},
doi = {10.1111/eci.70237},
note = {PMID: 42299459},
}
TY - JOUR AU - Armentaro G AU - Crudo G AU - Menichelli D AU - Daidone M AU - Severini G AU - Fuoco C AU - Panza A AU - Pignatelli P AU - Andreozzi F AU - Sesti G TI - Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation. T2 - European journal of clinical investigation PY - 2026 DO - 10.1111/eci.70237 AN - PMID:42299459 ER -
INTRODUCTION: Atrial fibrillation (AF) is the most common arrhythmia in the elderly, and is associated with an increased risk of cardiovascular events (CVE). Hypoalbuminemia is an independent predictor of all-cause and cardiovascular mortality in general population. OBJECTIVES: The purpose of this work is to evaluate the possible predictive value of serum albumin (SA) on MACE occurrence, in a cohort of elderly patients with non-valvular AF and several comorbidities for long-term follow-up. METHODS: 1057 elderly with non-valvular AF were enrolled (75.92 ± 6.1years; 295 on VKAs and 762 on DOACs) and stratified according to median value of SA, 532 patients with SA ≤ 3.6 g/dL and 525 patients with SA > 3.6 g/dL. MACE (non-fatal ischemic stroke, non-fatal myocardial infarction and cardiovascular death), and non-cardiovascular mortality occurrence were evaluated during a median follow-up of 5.5 years (IQR 2.1-7.2). RESULTS: In the whole observational study, patients with SA ≤ 3.6 g/dL are associated with an increased risk of MACEs by 59%. In addition, 10-year ageing are associated with an increased risk of MACE; in contrast, a MNA score > 24 pt and therapy with DOACs are associated with a reduced risk of MACE. CONCLUSION: Elderly patients with non-valvular AF with SA ≤ 3.6 g/dL show a higher risk of MACE and non-cardiovascular mortality.