The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke.
R, Y., X, Q., Y, D., K, Y., H, G., Y, J., S, C., X, M., Y, W., & X, Z. (2026). The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke.. Journal of the American Heart Association. https://doi.org/10.1161/JAHA.125.047271
R Y, X Q, Y D, K Y, H G, Y J, et al. The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke.. Journal of the American Heart Association. 2026; doi: 10.1161/JAHA.125.047271
R Y, X Q, Y D, et al. The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke.[J]. Journal of the American Heart Association. 2026. DOI: 10.1161/JAHA.125.047271.
@article{r2026,
author = {Yan R and Qiu X and Dai Y and Yang K and Gu H and Jiang Y and Cheng S and Meng X and Wang Y and Zhao X},
title = {The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke.},
journal = {Journal of the American Heart Association},
year = {2026},
doi = {10.1161/JAHA.125.047271},
note = {PMID: 42294757},
}
TY - JOUR AU - Yan R AU - Qiu X AU - Dai Y AU - Yang K AU - Gu H AU - Jiang Y AU - Cheng S AU - Meng X AU - Wang Y AU - Zhao X TI - The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large-Artery Atherosclerotic Acute Ischemic Stroke. T2 - Journal of the American Heart Association PY - 2026 DO - 10.1161/JAHA.125.047271 AN - PMID:42294757 ER -
BACKGROUND: GNB3 C825T polymorphism affects G protein-coupled receptor signaling, influencing platelet function, inflammation, and cardiovascular risk. This study aimed to investigate the unknown effects of the GNB3 C825T polymorphism on recurrent stroke risk in large-artery atherosclerosis and its potential interaction with antiplatelet therapy. METHODS: Using the CNSR-III (Third China National Stroke Registry) data, we analyzed 1233 patients with large-artery atherosclerotic acute ischemic stroke enrolled within 72 hours of onset. Whole-genome sequencing was performed to identify the GNB3 C825T polymorphism. Cox regression analysis was used to assess its association with 1-year recurrent ischemic stroke after adjusting for vascular risk factors. Associations with antiplatelet regimens and mediating effects of inflammatory biomarkers in the overall cohort were also evaluated. RESULTS: Carriers of the GNB3 825T-allele (CT/TT, 72.7%) exhibited a significantly lower risk of 1-year recurrent ischemic stroke than noncarriers (adjusted hazard ratio, 0.67 [95% CI, 0.48-0.93]; P=0.02). In exploratory analyses, the association was observed in the aspirin monotherapy subgroup, but the interaction with aspirin use was not significant. Elevated baseline interleukin-6 partially attenuated this genetic protection in the overall cohort (mediation proportion, -9.82%; P=0.02). CONCLUSIONS: The GNB3 825T-allele was associated with a reduced risk of recurrent stroke in patients with large-artery atherosclerotic acute ischemic stroke. In exploratory analyses, this association was observed in the aspirin monotherapy subgroup; however, the formal interaction with aspirin use was not statistically significant. These findings support a potential prognostic role of the GNB3 C825T polymorphism and warrant further validation in independent cohorts.