Microbial metabolite-driven mechanisms linking the gut microbiome to atherosclerosis: multi-omic and translational perspectives.
Atherosclerotic cardiovascular disease remains the leading cause of mortality worldwide, and a substantial residual risk persists despite optimal management of traditional risk factors. Increasing evi...
Elevated atherogenic index of plasma is associated with severe acute kidney injury in critically ill patients with cardiovascular disease - a MIMIC-IV analysis with external validation in the eICU-CRD database.
The atherogenic index of plasma (AIP) is a lipid-based marker of cardiovascular risk, yet its prognostic value for severe acute kidney injury (AKI) in critically ill patients with cardiovascular disea...
Associations of atherogenic index of plasma related indices with subclinical carotid atherosclerosis.
BACKGROUND: Evidence regarding the relationships between atherogenic index of plasma (AIP)-related indices and carotid atherosclerosis (CA) is limited. METHODS: A total of 59123 participants from the ...
Association of atherogenic index of plasma with urine albumin-to-creatinine ratio in Chinese urban adults: a cross-sectional study.
The association between the atherogenic index of plasma (AIP) and urine albumin-to-creatinine ratio (UACR) has not been fully elucidated in large-scale populations. This study aimed to systematically ...
Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review).
Mitochondria‑associated membranes (MAMs) are specialized contact sites between the endoplasmic reticulum and mitochondria, and serve as the structural foundation for material exchange and signal trans...
Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review).
Atherosclerosis (AS) is the principal pathological basis of cardiovascular disease and develops through the coordinated progression of endothelial dysfunction, lipid accumulation, macrophage foam‑cell...
Mechanistic Insights Into the Association Between Gut Microbiota Diversity and Atherosclerosis, Acute Coronary Syndrome, and Peripheral Arterial Disease Progression.
BACKGROUND: The gut microbiome has emerged as a potential contributor to cardiovascular diseases (CVDs), including atherosclerosis, acute coronary syndrome (ACS), and peripheral arterial disease (PAD)...
Punch skin grafting for patients with no-option for revascularisation chronic limb-threatening ischaemia: A case series.
OBJECTIVE: No-option for revascularisation Chronic Limb-Threatening Ischaemia (CLTI) is often a terminal diagnosis for older patients, leading to survival and limb preservation rates that are of conce...
Patients' experiences living with claudication and healthcare professionals' perspectives of managing the condition: A qualitative study.
BACKGROUND: Peripheral artery disease (PAD) and claudication significantly affects mobility, leading to disability and reduced participation in daily activities. Regular physical activity improves wal...
The claudication symptoms questionnaire: Patient directed development and testing.
BACKGROUND: Symptomatic peripheral artery disease (PAD) is defined as calf pain when walking. However, over 70% of patients with PAD suffer from symptoms other than classic claudication pain (atypical...
The Case for Gulf Region-Specific Peripheral Artery Disease Trials: A Comprehensive Literature Review.
Peripheral artery disease (PAD) research is globally underrepresented, with landmark trials like Best Endovascular Surgical Therapy for Patients with Critical Limb Ischemia and Bypass versus Angioplas...
Which Is Preferable for Chronic Limb-threatening Ischemia: Bypass versus Endovascular Therapy?
Chronic limb-threatening ischemia is the most advanced stage of peripheral arterial disease and typically requires revascularization to prevent limb-loss. The choice of open surgical bypass versus end...
From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review).
Aging is accompanied by a gradual loss of cellular function and systemic weakening of the homeostasis of multiple tissues, leading to a variety of age‑related diseases and eventual mortality. Super‑en...
Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.
The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming gr...
A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins.
Lipoproteins are essential for lipid transport in all bilaterians. A single Apolipoprotein B (ApoB) molecule is the inseparable structural scaffold of each ApoB-containing lipoprotein (B-lps), which a...
Berberine-associated lipid-inflammatory regulation in atherosclerosis: an integrative transcriptomic, single-cell, and in vivo study.
Atherosclerotic plaques combine disturbed lipid metabolism with myeloid inflammation, yet the human plaque context of berberine (BBR)-related targets remains poorly defined. Paired GSE43292 samples we...
Peripheral artery disease in patients with persistent claudication after lumbar spine surgery: a primary care reassessment framework.
Persistent claudication after lumbar spinal surgery may reflect unrecognised peripheral artery disease (PAD) and delayed implementation of secondary cardiovascular prevention. Despite effective guidel...
[Mechanism of herbal cake-separated moxibustion combined with atorvastatin in treating ApoE(-/-) atherosclerotic mice based on the integrin/YAP/JNK signaling pathway].
OBJECTIVES: To investigate the effects of herbal cake-separated moxibustion combined with atorvastatin on lipid metabolism, aortic pathological structure, plaque deposition, and integrin/ yes-associat...
Potential Role of Circulating Biomarkers in Peripheral Artery Disease.
PURPOSE OF REVIEW: To review evidence on the role of circulating biomarkers associated with lower extremity peripheral artery disease (PAD) and adverse outcomes in people with PAD. RECENT FINDINGS: Th...
Pathological depositions in human disease: converging mechanisms in atherosclerosis, Alzheimer's disease, and related disorders.
Pathological deposition of endogenous material within tissues represents a central, unifying mechanism across a broad spectrum of prevalent human diseases. Atherosclerosis and Alzheimer's disease (AD)...