Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study.
R, S., E, T., Y, A., Y, S.M., S, I., M, O., & H, K. (2026). Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study.. European journal of neurology. https://doi.org/10.1111/ene.70621
R S, E T, Y A, Y SM, S I, M O, et al. Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study.. European journal of neurology. 2026; doi: 10.1111/ene.70621
R S, E T, Y A, et al. Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study.[J]. European journal of neurology. 2026. DOI: 10.1111/ene.70621.
@article{r2026,
author = {Sugiyama R and Takeshita E and Aihara Y and Shimizu-Motohashi Y and Izumi S and Oba M and Komaki H},
title = {Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study.},
journal = {European journal of neurology},
year = {2026},
doi = {10.1111/ene.70621},
note = {PMID: 42227719},
}
TY - JOUR AU - Sugiyama R AU - Takeshita E AU - Aihara Y AU - Shimizu-Motohashi Y AU - Izumi S AU - Oba M AU - Komaki H TI - Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study. T2 - European journal of neurology PY - 2026 DO - 10.1111/ene.70621 AN - PMID:42227719 ER -
BACKGROUND: In Duchenne muscular dystrophy (DMD), cardiac causes account for approximately 30% of all deaths. Therefore, evaluating cardiac function in older patients is important. In addition, current recommendations advise screening for arrhythmias when left ventricular dysfunction is identified; however, the evidence base underpinning this recommendation in DMD is limited. Furthermore, large-scale cohort studies with substantial adult representation are lacking. METHODS: To characterize arrhythmia profiles of patients with DMD, we analyzed 1018 Holter electrocardiographic recordings from 167 patients with DMD (age: 9-44 years). RESULTS: Bradyarrhythmia and supraventricular tachyarrhythmia were rare; nonsustained ventricular tachycardia (NSVT) and ≥ 720 premature ventricular complexes per 24 h were detected in 85 (8.3%) and 124 (12.2%) recordings, respectively. Logistic regression identified reduced left ventricular function as the strongest associated factor for NSVT. Although statistically nonsignificant, risk increased with age, nonuse of noninvasive positive-pressure ventilation, and a Dp140-deficient genotype. A Dp116-deficient genotype was associated with lower odds of NSVT. CONCLUSIONS: Given that NSVT may trigger sudden cardiac death in susceptible patients with underlying cardiac disease, regular Holter electrocardiographic monitoring is warranted in patients at high risk of NSVT.