Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy.
H, E., A, B., B, J., N, S., GYH, L., & I, W. (2026). Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy.. Diseases of the esophagus : official journal of the International Society for Diseases of the Esopha. https://doi.org/10.1093/dote/doag058
H E, A B, B J, N S, GYH L, I W. Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy.. Diseases of the esophagus : official journal of the International Society for Diseases of the Esopha. 2026; doi: 10.1093/dote/doag058
H E, A B, B J, et al. Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy.[J]. Diseases of the esophagus : official journal of the International Society for Diseases of the Esopha. 2026. DOI: 10.1093/dote/doag058.
@article{h2026,
author = {Essa H and Balu A and Johnston B and Stephens N and Lip GYH and Welters I},
title = {Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy.},
journal = {Diseases of the esophagus : official journal of the International Society for Diseases of the Esopha},
year = {2026},
doi = {10.1093/dote/doag058},
note = {PMID: 42328848},
}
TY - JOUR AU - Essa H AU - Balu A AU - Johnston B AU - Stephens N AU - Lip GYH AU - Welters I TI - Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy. T2 - Diseases of the esophagus : official journal of the International Society for Diseases of the Esopha PY - 2026 DO - 10.1093/dote/doag058 AN - PMID:42328848 ER -
New-onset atrial fibrillation (NOAF) is a frequent complication after esophagectomy. While associated with adverse short-term outcomes, its longer-term cardiovascular impact remains uncertain. We evaluated associations between NOAF and postoperative cardiovascular and respiratory complications using a large international real-world dataset. We performed a retrospective cohort study using the TriNetX global federated health research network. Adults undergoing esophagectomy were identified using ICD-10, CPT, and SNOMED codes, excluding those with prior atrial fibrillation or flutter. NOAF was defined within 30 days postoperatively. Propensity score matching (1:1) balanced demographics, comorbidities, and medication use. Outcomes were assessed over 12 months using Cox proportional hazards models. We analyzed 1977 matched patients (mean age 67.1 ± 8.7 years; 18% female). Within 0-3 months, NOAF was associated with increased risks of death (HR 2.09, 95% CI 1.62-2.70), heart failure (HR 2.03, 95% CI 1.32-3.11), myocardial infarction (HR 2.35, 95% CI 1.17-4.74), pneumonia (HR 1.80, 95% CI 1.42-2.29), venous thromboembolism (HR 1.76, 95% CI 1.17-2.66), and rehospitalization (HR 2.78, 95% CI 2.42-3.20), with no significant association for stroke. Between 3 and 12 months, elevated risks persisted for death (HR 1.60, 95% CI 1.30-1.98) and heart failure (HR 2.55, 95% CI 1.37-4.73). Across 12 months, NOAF remained associated with death (HR 1.76, 95% CI 1.50-2.07) and heart failure (HR 2.23, 95% CI 1.56-3.19). NOAF after esophagectomy identifies patients at increased risk of major postoperative and cardiovascular complications, particularly early after surgery.