终末期肾病、主要心血管事件和死亡与全身炎症的关系
Halimi, J.M., Maisons, V., Fréminville, J.B.d., Roger, S., Bisson, A., Chadet, S., & Fauchier, L. (2026). ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation. Kidney International Reports. https://doi.org/10.1016/j.ekir.2026.106364
Halimi JM, Maisons V, Fréminville JBd, Roger S, Bisson A, Chadet S, et al. ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation. Kidney International Reports. 2026; doi: 10.1016/j.ekir.2026.106364
Halimi JM, Maisons V, Fréminville JBd, et al. ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation[J]. Kidney International Reports. 2026. DOI: 10.1016/j.ekir.2026.106364.
@article{halimi2026,
author = {Jean-Marc Halimi and Vincent Maisons and Jean-Baptiste de Fréminville and Sébastien Roger and Antoine Bisson and Sophie Chadet and Laurent Fauchier},
title = {ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation},
journal = {Kidney International Reports},
year = {2026},
doi = {10.1016/j.ekir.2026.106364},
note = {PMID: 41853745},
}
TY - JOUR AU - Jean-Marc Halimi AU - Vincent Maisons AU - Jean-Baptiste de Fréminville AU - Sébastien Roger AU - Antoine Bisson AU - Sophie Chadet AU - Laurent Fauchier TI - ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation T2 - Kidney International Reports PY - 2026 DO - 10.1016/j.ekir.2026.106364 AN - PMID:41853745 ER -
全身炎症可能在慢性肾病的进展和主要心血管事件（MACE）的发展中发挥作用，但这种效应是否独立于传统心血管危险因素尚不清楚。本研究评估了炎症标志物与终末期肾病（ESKD）患者主要心血管事件和死亡之间的关系。研究纳入了接受透析治疗的ESKD患者，测量了多种炎症标志物（包括C反应蛋白、白细胞介素-6等），并进行了长期随访。主要终点为主要心血管事件（定义为心血管死亡、非致死性心肌梗死和非致死性卒中的复合终点）和全因死亡。结果显示，升高的全身炎症标志物与MACE风险和全因死亡率独立相关，即使在校正传统心血管危险因素后仍然显著。炎症标志物升高的患者发生动脉粥样硬化性心血管事件的风险更高。研究结果表明，全身炎症是ESKD患者心血管结局的重要独立预测因子，提示抗炎治疗可能成为改善ESKD患者心血管预后的潜在策略。