Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality.
H, S., S, D., SK, J., MC, O., V, H., C, S., TK, B., F, D., & DC, R. (2026). Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality.. European journal of gastroenterology & hepatology. https://doi.org/10.1097/MEG.0000000000003223
H S, S D, SK J, MC O, V H, C S, et al. Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality.. European journal of gastroenterology & hepatology. 2026; doi: 10.1097/MEG.0000000000003223
H S, S D, SK J, et al. Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality.[J]. European journal of gastroenterology & hepatology. 2026. DOI: 10.1097/MEG.0000000000003223.
@article{h2026,
author = {Sanekommu H and Dandu S and Jayaswal SK and Ozkan MC and Hapshy V and Schreiber C and Bhatti TK and Deshmukh F and Rockey DC},
title = {Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality.},
journal = {European journal of gastroenterology & hepatology},
year = {2026},
doi = {10.1097/MEG.0000000000003223},
note = {PMID: 42335427},
}
TY - JOUR AU - Sanekommu H AU - Dandu S AU - Jayaswal SK AU - Ozkan MC AU - Hapshy V AU - Schreiber C AU - Bhatti TK AU - Deshmukh F AU - Rockey DC TI - Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality. T2 - European journal of gastroenterology & hepatology PY - 2026 DO - 10.1097/MEG.0000000000003223 AN - PMID:42335427 ER -
BACKGROUND: Alcohol consumption is associated with increased risk for development of atrial fibrillation. Outcomes of patients with atrial fibrillation in the context of acute alcohol-associated hepatitis have yet to be investigated. METHODS: We performed a retrospective study of patients with alcohol-associated hepatitis from the National Inpatient Sample (2016-2019), comparing those with and without concurrent atrial fibrillation. Subgroup analysis with and without cirrhosis was alone performed. Statistical analysis performed using STATA 16.1 and multivariate logistic and linear regression. RESULTS: Among 475 600 patients with alcohol-associated hepatitis, 27 675 (5.8%) had atrial fibrillation. Patients with atrial fibrillation had a nearly two-fold increased in-hospital mortality (6.9%) compared with those without atrial fibrillation (3.9%) [adjusted odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.20-1.53] and higher odds of developing acute kidney injury (OR = 1.23, 95% CI = 1.15-1.32). They also had longer hospital stays and higher total hospital charges (7.5 vs. 6.0 days and $20 005 vs. $14 714, respectively). Among patients with alcohol-associated hepatitis and atrial fibrillation, 33% also had cirrhosis (n = 9190), and these patients had an even higher mortality rate (11.3%) than those with alcohol-associated hepatitis and atrial fibrillation alone (4.7%). Acute coronary syndrome, chronic kidney disease, and obesity were independently associated with increased mortality. CONCLUSION: Patients with alcohol-associated hepatitis who have atrial fibrillation have an increased risk of in-hospital mortality and underlying cirrhosis compounds this risk. Early recognition of the effect of concomitant atrial fibrillation and alcohol-associated hepatitis could provide an opportunity for intervention.