促卵泡激素在绝经后女性冠状动脉粥样硬化中的新兴作用：综合综述
Wang, Z. & Yao, H. (2026). Follicle-Stimulating Hormone and Its Emerging Role in Coronary Atherosclerosis Among Postmenopausal Women: A Comprehensive Review. International Journal of Women's Health. https://doi.org/10.2147/IJWH.S571490
Wang Z, Yao H. Follicle-Stimulating Hormone and Its Emerging Role in Coronary Atherosclerosis Among Postmenopausal Women: A Comprehensive Review. International Journal of Women's Health. 2026; doi: 10.2147/IJWH.S571490
Wang Z, Yao H. Follicle-Stimulating Hormone and Its Emerging Role in Coronary Atherosclerosis Among Postmenopausal Women: A Comprehensive Review[J]. International Journal of Women's Health. 2026. DOI: 10.2147/IJWH.S571490.
@article{wang2026,
author = {Zijing Wang and Hao Yao},
title = {Follicle-Stimulating Hormone and Its Emerging Role in Coronary Atherosclerosis Among Postmenopausal Women: A Comprehensive Review},
journal = {International Journal of Women's Health},
year = {2026},
doi = {10.2147/IJWH.S571490},
note = {PMID: 41853671},
}
TY - JOUR AU - Zijing Wang AU - Hao Yao TI - Follicle-Stimulating Hormone and Its Emerging Role in Coronary Atherosclerosis Among Postmenopausal Women: A Comprehensive Review T2 - International Journal of Women's Health PY - 2026 DO - 10.2147/IJWH.S571490 AN - PMID:41853671 ER -
绝经后女性心血管疾病的发病率急剧上升，尤其是冠心病，已成为全球女性面临的主要健康问题。以往的观点认为，雌激素水平下降是绝经后女性风险升高的主要原因。近年来，越来越多的证据表明，绝经后水平急剧升高的促卵泡激素（FSH）可能在此过程中发挥关键作用。本文系统总结了来自临床和动物研究的现有证据，评估了FSH与绝经后女性冠心病风险之间的关系，探索了相互矛盾的证据，并检查了其在动脉粥样硬化发病机制和心脏代谢风险因素调节中的潜在作用。多项研究证实，升高的FSH通过结合肝脏和炎症细胞中的促卵泡激素受体（FSHR），干扰脂质代谢并加剧血管炎症，从而促进冠心病的进展。流行病学证据也支持这一观点。然而，一些临床研究显示了不同的证据，表明FSH在某些情况下可能发挥保护作用，可能通过影响各种代谢途径。本综述强调了FSH和FSHR作为绝经后人群冠脉粥样硬化风险分层、评估和干预的生物标志物和治疗靶点的潜力。