急性低氧呼吸衰竭中的高流量或标准氧气。
Frat, J.P., Quenot, J.P., Guitton, C., Coudroy, R., Gacouin, A., Badie, J., Demoule, A., Contou, D., Carteaux, G., Ehrmann, S., Jarousseau, F., Sedillot, N., Rigaud, J.P., Reignier, J., Beloncle, F., Dureau, A.F., Ferré, A., Daubin, C., Bourreau, A., . . . Thille, A.W. (2026). High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure.. N Engl J Med. https://doi.org/10.1056/NEJMoa2516087
Frat JP, Quenot JP, Guitton C, Coudroy R, Gacouin A, Badie J, et al. High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure.. N Engl J Med. 2026; doi: 10.1056/NEJMoa2516087
Frat JP, Quenot JP, Guitton C, et al. High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure.[J]. N Engl J Med. 2026. DOI: 10.1056/NEJMoa2516087.
@article{frat2026,
author = {Jean-Pierre Frat and Jean-Pierre Quenot and Christophe Guitton and Rémi Coudroy and Arnaud Gacouin and Julio Badie and Alexandre Demoule and Damien Contou and Guillaume Carteaux and Stephan Ehrmann and Fabien Jarousseau and Nicholas Sedillot and Jean-Philippe Rigaud and Jean Reignier and François Beloncle and Anne-Florence Dureau and Alexis Ferré and Cédric Daubin and Anna Bourreau and Agathe Delbove and Gaël Pradel and Abdelhamid Fatah and Gwenhael Colin and Guillaume Deniel and Olivier Lamouret and Béatrice La Combe and Gwénaël Prat and Louis-Marie Galerneau and Gaël Bourdin and Gautier Julien and Anaïs Curtiaud and Mélanie Saint-Léger and Emanuele Turbil and Faustine Reynaud and Louis Chamblet and Stéphanie Ragot and Arnaud W Thille},
title = {High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure.},
journal = {N Engl J Med},
year = {2026},
doi = {10.1056/NEJMoa2516087},
note = {PMID: 41841715},
}
TY - JOUR AU - Jean-Pierre Frat AU - Jean-Pierre Quenot AU - Christophe Guitton AU - Rémi Coudroy AU - Arnaud Gacouin AU - Julio Badie AU - Alexandre Demoule AU - Damien Contou AU - Guillaume Carteaux AU - Stephan Ehrmann AU - Fabien Jarousseau AU - Nicholas Sedillot AU - Jean-Philippe Rigaud AU - Jean Reignier AU - François Beloncle AU - Anne-Florence Dureau AU - Alexis Ferré AU - Cédric Daubin AU - Anna Bourreau AU - Agathe Delbove AU - Gaël Pradel AU - Abdelhamid Fatah AU - Gwenhael Colin AU - Guillaume Deniel AU - Olivier Lamouret AU - Béatrice La Combe AU - Gwénaël Prat AU - Louis-Marie Galerneau AU - Gaël Bourdin AU - Gautier Julien AU - Anaïs Curtiaud AU - Mélanie Saint-Léger AU - Emanuele Turbil AU - Faustine Reynaud AU - Louis Chamblet AU - Stéphanie Ragot AU - Arnaud W Thille TI - High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure. T2 - N Engl J Med PY - 2026 DO - 10.1056/NEJMoa2516087 AN - PMID:41841715 ER -
Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. In this multicenter, open-label trial, we randomly assigned patients who had acute hypoxemic respiratory failure to receive high-flow-oxygen or standard-oxygen therapy. All the patients had a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of 200 or less, a respiratory rate of more than 25 breaths per minute, and pulmonary infiltrate on chest imaging. The primary outcome was death by day 28. A total of 1116 patients underwent randomization. Of these patients, 1110 (556 in the high-flow-oxygen group and 554 in the standard-oxygen group) were included in the analysis. Mortality at day 28 was 14.6% (in 81 of 556 patients) in the high-flow-oxygen group and 14.6% (in 81 of 554 patients) in the standard-oxygen group (difference, -0.05 percentage points; 95% confidence interval [CI], -4.21 to 4.10; P = 0.98). The incidence of intubation by day 28 was 42.4% (in 236 of 556 patients) in the high-flow-oxygen group and 48.4% (in 268 of 554 patients) in the standard-oxygen group (difference, -5.93 percentage points; 95% CI, -11.78 to -0.08). Serious adverse events (cardiac arrest or pneumothorax) occurred during spontaneous breathing in 13 patients (2.3%) in the high-flow-oxygen group and in 6 patients (1.1%) in the standard-oxygen group. Among patients with acute hypoxemic respiratory failure, the use of oxygen delivered through a high-flow nasal cannula did not significantly reduce mortality at day 28. (Funded by the French Ministry of Health and Fisher and Paykel Healthcare; SOHO ClinicalTrials.gov number, NCT04468126.).