短暂性脑缺血发作或轻微脑卒中后中风长期风险的预后因素：系统评价和荟萃分析。
Khan, F., Yogendrakumar, V., Lun, R., Marx, C.E., Rochwerg, B., Tran, A., Fernando, S.M., Ganesh, A., Barber, P.A., Ögren, J., Ois, A., Giralt-Steinhauer, E., Khanevski, A.N., Leng, X., Tian, X., Leung, T.W., Verburgt, E., Verhoeven, J., Leeuw, F.E.d., . . . Hill, M.D. (2026). Prognostic Factors for Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis.. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.125.078763
Khan F, Yogendrakumar V, Lun R, Marx CE, Rochwerg B, Tran A, et al. Prognostic Factors for Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis.. Circulation. 2026; doi: 10.1161/CIRCULATIONAHA.125.078763
Khan F, Yogendrakumar V, Lun R, et al. Prognostic Factors for Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis.[J]. Circulation. 2026. DOI: 10.1161/CIRCULATIONAHA.125.078763.
@article{khan2026,
author = {Faizan Khan and Vignan Yogendrakumar and Ronda Lun and Caterina E Marx and Bram Rochwerg and Alexandre Tran and Shannon M Fernando and Aravind Ganesh and Philip A Barber and Joachim Ögren and Angel Ois and Eva Giralt-Steinhauer and Andrej Netland Khanevski and Xinyi Leng and Xuan Tian and Thomas W Leung and Esmee Verburgt and Jamie Verhoeven and Frank-Erik de Leeuw and Fredrik Ildstad and Simon Fandler-Höfler and Karoliina Aarnio and Bettina von Sarnowski and Diane L Lorenzetti and Shelagh B Coutts and Pierre Amarenco and Graeme J Hankey and Michael D Hill},
title = {Prognostic Factors for Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis.},
journal = {Circulation},
year = {2026},
doi = {10.1161/CIRCULATIONAHA.125.078763},
note = {PMID: 41849763},
}
TY - JOUR AU - Faizan Khan AU - Vignan Yogendrakumar AU - Ronda Lun AU - Caterina E Marx AU - Bram Rochwerg AU - Alexandre Tran AU - Shannon M Fernando AU - Aravind Ganesh AU - Philip A Barber AU - Joachim Ögren AU - Angel Ois AU - Eva Giralt-Steinhauer AU - Andrej Netland Khanevski AU - Xinyi Leng AU - Xuan Tian AU - Thomas W Leung AU - Esmee Verburgt AU - Jamie Verhoeven AU - Frank-Erik de Leeuw AU - Fredrik Ildstad AU - Simon Fandler-Höfler AU - Karoliina Aarnio AU - Bettina von Sarnowski AU - Diane L Lorenzetti AU - Shelagh B Coutts AU - Pierre Amarenco AU - Graeme J Hankey AU - Michael D Hill TI - Prognostic Factors for Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis. T2 - Circulation PY - 2026 DO - 10.1161/CIRCULATIONAHA.125.078763 AN - PMID:41849763 ER -
Patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of subsequent stroke that persists for at least 10 years. We aimed to identify prognostic factors associated with long-term risk of stroke in this patient group, and estimate their population attribution fraction (PAF). A systematic review was performed of MEDLINE, Embase, and Web of Science for cohort studies including patients with TIA or minor stroke that evaluated factors for subsequent stroke over a follow-up period of ≥1 year. We pooled hazard ratios adjusted for relevant confounders using random-effect meta-analysis and determined the PAF of factors based on their pooled prevalence and adjusted hazard ratio (aHR). We assessed certainty of evidence using the Grading of Recommendations, Assessment, Development, and Evaluation approach. The study is registered in PROSPERO (CRD42023476551). From 14 732 identified citations, we included 28 cohort studies comprising 86 810 patients with TIA or minor stroke (median age, 69 years [IQR, 65-71]; 52-60% male patients). Factors that had high certainty evidence of association with increased long-term risk of stroke included older age (aHR 1.04 per year increase, 95% CI 1.02-1.05), male sex (1.25, 1.15-1.36; PAF 13.0%, 95% CI 7.8-18.7), atrial fibrillation (1.34, 1.18-1.52; 3.8%, 95% CI 0.3-9.9), diabetes mellitus (1.52, 1.32-1.75; 7.7%, 3.1-14.1), hypertension (1.60, 1.31-1.94; 19.3%, 8.4-31.6), ischemic heart disease (1.67, 1.28-2.18; 10.7%, 2.8-22.9), history of stroke or TIA before the index event (1.70, 1.43-2.02; 12.0%, 5.2-21.4), smoking (1.29, 1.05-1.60; 11.2%, 1.0-30.7), ABCD These findings can help identify patients with a particularly enduring risk of stroke who are most likely to benefit from ongoing monitoring and treatment, and facilitate the development and implementation of targeted stroke prevention strategies.