美金刚治疗房性早搏:一项II期随机临床试验
Shen, Y., Zeng, C., Sun, Y., Wang, J., Yu, B., Cheng, X., Guo, X., Wang, D., Li, Y., Han, W., Zhou, B., Sheng, H., Huang, Z., Li, Y., Fu, G., Zhang, J., Xie, D., Liang, D., Liu, Y., . . . Chen, Y. (2026). Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.125.079023
Shen Y, Zeng C, Sun Y, Wang J, Yu B, Cheng X, et al. Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. Circulation. 2026; doi: 10.1161/CIRCULATIONAHA.125.079023
Shen Y, Zeng C, Sun Y, et al. Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial[J]. Circulation. 2026. DOI: 10.1161/CIRCULATIONAHA.125.079023.
@article{shen2026,
author = {Yan Shen and Chenxi Zeng and Yan Sun and Jing Wang and Bo Yu and Xiaogang Cheng and Xinchun Guo and Dawei Wang and Ying Li and Wei Han and Bin Zhou and He Sheng and Zexin Huang and Yan Li and Gang Fu and Jun Zhang and Dongmei Xie and Daxin Liang and Ying Liu and Bin Yang and Qingmiao Zhang and Rong Duan and Hao Li and Bin Zhang and Yinan Wu and Liang Zheng and Jin He and Sheng Liu and Di Yin and Guoli Sun and Shijie Zhang and Xin Guo and Ming Zhang and Ying Wang and Xi Hu and Jing Zeng and Xiaofeng Yang and Shuang Li and Ning Li and Fei Hu and Hao Wang and Xiaoyi Hu and Yi Wang and Chuansheng Wang and Kai Yang and Jianhui Wang and Yujie Wang and Jue Lai and Ling Wang and Kai Xiong and Ge Wang and Qiang Zou and Bin Shao and Zhong Chen and Yibo Wu and Jia Leng and Jiang Pu and Chao Ma and Yundai Chen},
title = {Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial},
journal = {Circulation},
year = {2026},
doi = {10.1161/CIRCULATIONAHA.125.079023},
note = {PMID: 41853846},
}
TY - JOUR AU - Yan Shen AU - Chenxi Zeng AU - Yan Sun AU - Jing Wang AU - Bo Yu AU - Xiaogang Cheng AU - Xinchun Guo AU - Dawei Wang AU - Ying Li AU - Wei Han AU - Bin Zhou AU - He Sheng AU - Zexin Huang AU - Yan Li AU - Gang Fu AU - Jun Zhang AU - Dongmei Xie AU - Daxin Liang AU - Ying Liu AU - Bin Yang AU - Qingmiao Zhang AU - Rong Duan AU - Hao Li AU - Bin Zhang AU - Yinan Wu AU - Liang Zheng AU - Jin He AU - Sheng Liu AU - Di Yin AU - Guoli Sun AU - Shijie Zhang AU - Xin Guo AU - Ming Zhang AU - Ying Wang AU - Xi Hu AU - Jing Zeng AU - Xiaofeng Yang AU - Shuang Li AU - Ning Li AU - Fei Hu AU - Hao Wang AU - Xiaoyi Hu AU - Yi Wang AU - Chuansheng Wang AU - Kai Yang AU - Jianhui Wang AU - Yujie Wang AU - Jue Lai AU - Ling Wang AU - Kai Xiong AU - Ge Wang AU - Qiang Zou AU - Bin Shao AU - Zhong Chen AU - Yibo Wu AU - Jia Leng AU - Jiang Pu AU - Chao Ma AU - Yundai Chen TI - Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial T2 - Circulation PY - 2026 DO - 10.1161/CIRCULATIONAHA.125.079023 AN - PMID:41853846 ER -
房性早搏是最常见的心律失常之一,频繁的房性早搏可增加房颤、卒中和心力衰竭的风险,但目前尚无批准的特异性治疗药物。本研究为一项II期随机临床试验,旨在评估美金刚(一种NMDA受体拮抗剂)治疗房性早搏的疗效和安全性。美金刚通过阻断NMDA受体介导的过度交感神经激活,理论上可以减少房性异位激动。研究纳入了频繁房性早搏患者,随机分配至美金刚治疗组和安慰剂组,通过24小时动态心电图评估房性早搏负荷变化。主要终点为治疗8周后房性早搏减少的百分比。该研究为房性早搏的药物治疗提供了新的思路,如果证实有效,美金刚可能成为首个专门针对房性早搏的治疗药物,具有重要的临床意义。