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Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial

美金刚治疗房性早搏:一项II期随机临床试验

期刊: Circulation 日期: 2026-03-19 PMID: 41853846 DOI: 10.1161/CIRCULATIONAHA.125.079023 浏览: 50
作者: Yan Shen, Chenxi Zeng, Yan Sun, Jing Wang, Bo Yu, Xiaogang Cheng, Xinchun Guo, Dawei Wang, Ying Li, Wei Han, Bin Zhou, He Sheng, Zexin Huang, Yan Li, Gang Fu, Jun Zhang, Dongmei Xie, Daxin Liang, Ying Liu, Bin Yang, Qingmiao Zhang, Rong Duan, Hao Li, Bin Zhang, Yinan Wu, Liang Zheng, Jin He, Sheng Liu, Di Yin, Guoli Sun, Shijie Zhang, Xin Guo, Ming Zhang, Ying Wang, Xi Hu, Jing Zeng, Xiaofeng Yang, Shuang Li, Ning Li, Fei Hu, Hao Wang, Xiaoyi Hu, Yi Wang, Chuansheng Wang, Kai Yang, Jianhui Wang, Yujie Wang, Jue Lai, Ling Wang, Kai Xiong, Ge Wang, Qiang Zou, Bin Shao, Zhong Chen, Yibo Wu, Jia Leng, Jiang Pu, Chao Ma, Yundai Chen
Shen, Y., Zeng, C., Sun, Y., Wang, J., Yu, B., Cheng, X., Guo, X., Wang, D., Li, Y., Han, W., Zhou, B., Sheng, H., Huang, Z., Li, Y., Fu, G., Zhang, J., Xie, D., Liang, D., Liu, Y., . . . Chen, Y. (2026). Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.125.079023
Shen Y, Zeng C, Sun Y, Wang J, Yu B, Cheng X, et al. Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. Circulation. 2026; doi: 10.1161/CIRCULATIONAHA.125.079023
Shen Y, Zeng C, Sun Y, et al. Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial[J]. Circulation. 2026. DOI: 10.1161/CIRCULATIONAHA.125.079023.
@article{shen2026,
  author = {Yan Shen and Chenxi Zeng and Yan Sun and Jing Wang and Bo Yu and Xiaogang Cheng and Xinchun Guo and Dawei Wang and Ying Li and Wei Han and Bin Zhou and He Sheng and Zexin Huang and Yan Li and Gang Fu and Jun Zhang and Dongmei Xie and Daxin Liang and Ying Liu and Bin Yang and Qingmiao Zhang and Rong Duan and Hao Li and Bin Zhang and Yinan Wu and Liang Zheng and Jin He and Sheng Liu and Di Yin and Guoli Sun and Shijie Zhang and Xin Guo and Ming Zhang and Ying Wang and Xi Hu and Jing Zeng and Xiaofeng Yang and Shuang Li and Ning Li and Fei Hu and Hao Wang and Xiaoyi Hu and Yi Wang and Chuansheng Wang and Kai Yang and Jianhui Wang and Yujie Wang and Jue Lai and Ling Wang and Kai Xiong and Ge Wang and Qiang Zou and Bin Shao and Zhong Chen and Yibo Wu and Jia Leng and Jiang Pu and Chao Ma and Yundai Chen},
  title = {Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial},
  journal = {Circulation},
  year = {2026},
  doi = {10.1161/CIRCULATIONAHA.125.079023},
  note = {PMID: 41853846},
}
TY  - JOUR
AU  - Yan Shen
AU  - Chenxi Zeng
AU  - Yan Sun
AU  - Jing Wang
AU  - Bo Yu
AU  - Xiaogang Cheng
AU  - Xinchun Guo
AU  - Dawei Wang
AU  - Ying Li
AU  - Wei Han
AU  - Bin Zhou
AU  - He Sheng
AU  - Zexin Huang
AU  - Yan Li
AU  - Gang Fu
AU  - Jun Zhang
AU  - Dongmei Xie
AU  - Daxin Liang
AU  - Ying Liu
AU  - Bin Yang
AU  - Qingmiao Zhang
AU  - Rong Duan
AU  - Hao Li
AU  - Bin Zhang
AU  - Yinan Wu
AU  - Liang Zheng
AU  - Jin He
AU  - Sheng Liu
AU  - Di Yin
AU  - Guoli Sun
AU  - Shijie Zhang
AU  - Xin Guo
AU  - Ming Zhang
AU  - Ying Wang
AU  - Xi Hu
AU  - Jing Zeng
AU  - Xiaofeng Yang
AU  - Shuang Li
AU  - Ning Li
AU  - Fei Hu
AU  - Hao Wang
AU  - Xiaoyi Hu
AU  - Yi Wang
AU  - Chuansheng Wang
AU  - Kai Yang
AU  - Jianhui Wang
AU  - Yujie Wang
AU  - Jue Lai
AU  - Ling Wang
AU  - Kai Xiong
AU  - Ge Wang
AU  - Qiang Zou
AU  - Bin Shao
AU  - Zhong Chen
AU  - Yibo Wu
AU  - Jia Leng
AU  - Jiang Pu
AU  - Chao Ma
AU  - Yundai Chen
TI  - Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial
T2  - Circulation
PY  - 2026
DO  - 10.1161/CIRCULATIONAHA.125.079023
AN  - PMID:41853846
ER  - 

摘要

房性早搏是最常见的心律失常之一,频繁的房性早搏可增加房颤、卒中和心力衰竭的风险,但目前尚无批准的特异性治疗药物。本研究为一项II期随机临床试验,旨在评估美金刚(一种NMDA受体拮抗剂)治疗房性早搏的疗效和安全性。美金刚通过阻断NMDA受体介导的过度交感神经激活,理论上可以减少房性异位激动。研究纳入了频繁房性早搏患者,随机分配至美金刚治疗组和安慰剂组,通过24小时动态心电图评估房性早搏负荷变化。主要终点为治疗8周后房性早搏减少的百分比。该研究为房性早搏的药物治疗提供了新的思路,如果证实有效,美金刚可能成为首个专门针对房性早搏的治疗药物,具有重要的临床意义。

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