Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.
S, A., B, M., R, T., I, M., S, K., N, K., BS, Y., W, A., O, M.A., & S, P. (2026). Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.. Gut microbes. https://doi.org/10.1080/19490976.2026.2691346
S A, B M, R T, I M, S K, N K, et al. Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.. Gut microbes. 2026; doi: 10.1080/19490976.2026.2691346
S A, B M, R T, et al. Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.[J]. Gut microbes. 2026. DOI: 10.1080/19490976.2026.2691346.
@article{s2026,
author = {Aryal S and Mell B and Tummala R and Manandhar I and Kumariya S and Kondapalli N and Yeoh BS and Ahlidja W and Mautin Akinola O and Pachhain S},
title = {Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension.},
journal = {Gut microbes},
year = {2026},
doi = {10.1080/19490976.2026.2691346},
note = {PMID: 42343158},
}
TY - JOUR AU - Aryal S AU - Mell B AU - Tummala R AU - Manandhar I AU - Kumariya S AU - Kondapalli N AU - Yeoh BS AU - Ahlidja W AU - Mautin Akinola O AU - Pachhain S TI - Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension. T2 - Gut microbes PY - 2026 DO - 10.1080/19490976.2026.2691346 AN - PMID:42343158 ER -
Gut microbiota and bile acids are increasingly recognized to regulate blood pressure, but the mechanisms remain unclear. Takeda G-protein coupled receptor 5 (TGR5) is a major receptor for secondary bile acids. We hypothesized that loss of TGR5 function remodels gut microbiota and influences blood pressure. Using CRISPR/Cas9, TGR5 knockout (Tgr5KO) rats on the Dahl Salt-Sensitive (S) background were generated and characterized. Compared to the control S rats, Tgr5KO rats demonstrated significantly lower blood pressure, a distinct shift in gut microbiota composition, and an increase in the secondary bile acid, particularly, glycodeoxycholic acid. Supplementation of glycodeoxycholic acid to the control S rats produced a similar gut microbial shift and lowered blood pressure. Furthermore, cecal microbiota transplantation from Tgr5KO to control S rats lowered blood pressure in the recipient rats. This first loss-of-function study demonstrates that deletion of TGR5 remodels gut microbiota, increases glycodeoxycholic acid, and lowers blood pressure regardless of TGR5 signaling status, identifying a promising gut-liver axis target for lowering hypertension.