运动通过PDE5A介导的血管平滑肌细胞表型转换抑制减轻主动脉夹层
Zhang, Y., Wu, C., Du, D., Hu, J., Li, Z., Wang, Y., Li, B., Mu, J., Chen, X., Yu, Y., Wu, N., & Zuo, S. (2026). Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/ATVBAHA.125.324293
Zhang Y, Wu C, Du D, Hu J, Li Z, Wang Y, et al. Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch. Arteriosclerosis, Thrombosis, and Vascular Biology. 2026; doi: 10.1161/ATVBAHA.125.324293
Zhang Y, Wu C, Du D, et al. Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch[J]. Arteriosclerosis, Thrombosis, and Vascular Biology. 2026. DOI: 10.1161/ATVBAHA.125.324293.
@article{zhang2026,
author = {Yi Zhang and Chunyan Wu and Dongdong Du and Jiayi Hu and Zhiqing Li and Yizeng Wang and Bochuan Li and Jiuke Mu and Xiongwen Chen and Ying Yu and Naishi Wu and Shengkai Zuo},
title = {Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch},
journal = {Arteriosclerosis, Thrombosis, and Vascular Biology},
year = {2026},
doi = {10.1161/ATVBAHA.125.324293},
note = {PMID: 41853865},
}
TY - JOUR AU - Yi Zhang AU - Chunyan Wu AU - Dongdong Du AU - Jiayi Hu AU - Zhiqing Li AU - Yizeng Wang AU - Bochuan Li AU - Jiuke Mu AU - Xiongwen Chen AU - Ying Yu AU - Naishi Wu AU - Shengkai Zuo TI - Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch T2 - Arteriosclerosis, Thrombosis, and Vascular Biology PY - 2026 DO - 10.1161/ATVBAHA.125.324293 AN - PMID:41853865 ER -
主动脉夹层是一种危及生命的疾病，涉及血管平滑肌细胞从收缩表型向合成表型的病理性转换。尽管运动具有广泛的心血管益处，但其在主动脉夹层发病机制中的作用尚不清楚。本研究旨在确定运动是否通过调节血管平滑肌细胞表型来减轻主动脉夹层，并阐明其潜在的分子机制。在人体主动脉夹层病变组织中，收缩型血管平滑肌细胞标志物（MYH11、CNN1和α-SMA）显著下调，而合成标志物骨桥蛋白上调。在β-氨基丙腈诱导的主动脉夹层小鼠模型中，运动提高了生存率，减少了主动脉扩张和夹层发生率，并维持了血管平滑肌细胞的收缩表型。RNA测序分析将PDE5A鉴定为关键的应答运动基因。血管平滑肌细胞特异性过表达PDE5A可减轻夹层进展，而抑制PDE5A则消除了运动的有益作用。进一步鉴定RUNX1为PDE5A的转录抑制因子，其在夹层状态下上调，而被运动所抑制。研究揭示了运动通过RUNX1-PDE5A轴对抗主动脉夹层的有益机制，为预防性治疗提供了新靶点。