Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico.
LS, T.C., S, R.O., G, C.P., B, V.H., G, C.G., A, G.O., C, F.O., FJ, H.M., JC, V.B., & MA, A.A. (2026). Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico.. Medical sciences (Basel, Switzerland). https://doi.org/10.3390/medsci14020304
LS TC, S RO, G CP, B VH, G CG, A GO, et al. Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico.. Medical sciences (Basel, Switzerland). 2026; doi: 10.3390/medsci14020304
LS TC, S RO, G CP, et al. Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico.[J]. Medical sciences (Basel, Switzerland). 2026. DOI: 10.3390/medsci14020304.
@article{ls2026,
author = {Torre-Cabrales LS and Ramírez-Ochoa S and Cervantes-Pérez G and Vicente-Hernández B and Cervantes-Guevara G and Gonzalez-Ojeda A and Fuentes-Orozco C and Hernandez-Mora FJ and Vázquez-Beltrán JC and Ambriz-Alarcón MA},
title = {Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico.},
journal = {Medical sciences (Basel, Switzerland)},
year = {2026},
doi = {10.3390/medsci14020304},
note = {PMID: 42346843},
}
TY - JOUR AU - Torre-Cabrales LS AU - Ramírez-Ochoa S AU - Cervantes-Pérez G AU - Vicente-Hernández B AU - Cervantes-Guevara G AU - Gonzalez-Ojeda A AU - Fuentes-Orozco C AU - Hernandez-Mora FJ AU - Vázquez-Beltrán JC AU - Ambriz-Alarcón MA TI - Frequency and Risk Factors for Diuretic Resistance in Patients with Decompensated Heart Failure: A Retrospective Single-Center Study in Western Mexico. T2 - Medical sciences (Basel, Switzerland) PY - 2026 DO - 10.3390/medsci14020304 AN - PMID:42346843 ER -
BACKGROUND/OBJECTIVES: Diuretic resistance is a recognized complication in patients with heart failure (HF) and is associated with worse clinical outcomes; however, information regarding its frequency and associated factors in hospitalized patients in Mexico is limited. This study aimed to describe the frequency of diuretic resistance in patients hospitalized with HF in a hospital unit in western Mexico and to identify factors associated with diuretic resistance. METHODS: This retrospective study used data obtained from clinical records. Patients older than 18 years with decompensated HF whose complete clinical records included the variables of interest were included. Patients were classified according to the presence or absence of diuretic resistance. Bivariate and multivariate analyses were performed to evaluate factors associated with diuretic resistance. RESULTS: A total of 76 patients were analyzed, and the frequency of diuretic resistance was 35.5% (n = 27). In bivariate analysis, type 2 diabetes mellitus, chronic kidney disease, elevated creatinine, urea, blood urea nitrogen (BUN), and urine protein levels, decreased glomerular filtration rate (GFR) and serum albumin, and prior treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and angiotensin-converting enzyme inhibitors/angiotensin II receptor antagonists (ACEI/AARII) were significantly associated with diuretic resistance. In the multivariate logistic regression model, prior ACEI/AARII treatment, history of type 2 diabetes mellitus, BUN levels, and serum albumin levels remained independently associated with diuretic resistance classification. CONCLUSIONS: Diuretic resistance was frequent in this cohort of patients hospitalized with decompensated heart failure, and several clinical and biochemical factors were independently associated with its occurrence. These findings may help identify patients at higher risk of diuretic resistance, although they should be confirmed in future prospective studies.