Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.
QC, Z., Q, Z., H, Z., Y, T., P, W., & XJ, L. (2026). Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.. International journal of molecular sciences. https://doi.org/10.3390/ijms27125278
QC Z, Q Z, H Z, Y T, P W, XJ L. Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.. International journal of molecular sciences. 2026; doi: 10.3390/ijms27125278
QC Z, Q Z, H Z, et al. Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.[J]. International journal of molecular sciences. 2026. DOI: 10.3390/ijms27125278.
@article{qc2026,
author = {Zhu QC and Zheng Q and Zhang H and Tu Y and Wang P and Liu XJ},
title = {Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.},
journal = {International journal of molecular sciences},
year = {2026},
doi = {10.3390/ijms27125278},
note = {PMID: 42352996},
}
TY - JOUR AU - Zhu QC AU - Zheng Q AU - Zhang H AU - Tu Y AU - Wang P AU - Liu XJ TI - Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting. T2 - International journal of molecular sciences PY - 2026 DO - 10.3390/ijms27125278 AN - PMID:42352996 ER -
Heart failure with preserved ejection fraction (HFpEF) represents a complex syndrome strongly associated with aging, characterized by diastolic dysfunction, myocardial stiffness, and chronic low-grade inflammation. Cellular senescence and the ensuing senescence-associated secretory phenotype (SASP) significantly contribute to the pathogenesis and progression of HFpEF. This review examines the biological properties of SASP and its mechanistic roles in driving myocardial fibrosis, microvascular dysfunction, and cardiomyocyte injury. We synthesize evidence from preclinical and clinical studies demonstrating how SASP factors orchestrate HFpEF pathophysiology. The therapeutic potential of targeting SASP pathways is critically evaluated, including senolytic agents that eliminate senescent cells and senomorphic compounds that inhibit SASP factor secretion. Finally, we identify key translational barriers, such as limited tissue specificity in senolytic delivery and inadequate SASP biomarkers for treatment monitoring, while outlining future research directions to advance novel therapeutic development for this increasingly prevalent condition.