[Research advances in the molecular mechanisms of microRNA-mediated macrophage lipid homeostasis and foam cell formation].
Z, G., Y, G., Z, X., T, G., H, Z., & S, S. (2026). [Research advances in the molecular mechanisms of microRNA-mediated macrophage lipid homeostasis and foam cell formation].. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
Z G, Y G, Z X, T G, H Z, S S. [Research advances in the molecular mechanisms of microRNA-mediated macrophage lipid homeostasis and foam cell formation].. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2026; PMID: 42350350
Z G, Y G, Z X, et al. [Research advances in the molecular mechanisms of microRNA-mediated macrophage lipid homeostasis and foam cell formation].[J]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2026.
@article{z2026,
author = {Guo Z and Guo Y and Xie Z and Guo T and Zhang H and Sun S},
title = {[Research advances in the molecular mechanisms of microRNA-mediated macrophage lipid homeostasis and foam cell formation].},
journal = {Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology},
year = {2026},
note = {PMID: 42350350},
}
TY - JOUR AU - Guo Z AU - Guo Y AU - Xie Z AU - Guo T AU - Zhang H AU - Sun S TI - [Research advances in the molecular mechanisms of microRNA-mediated macrophage lipid homeostasis and foam cell formation]. T2 - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology PY - 2026 AN - PMID:42350350 ER -
The progression of atherosclerosis (AS) is intrinsically associated with dysregulated lipid metabolism in macrophages, leading to the formation of foam cells. MicroRNA (miRNA) finely regulates the expression of key genes that govern cholesterol uptake, esterification, and efflux, thereby maintaining lipid homeostasis. Aberrant miRNA expression disrupts this balance and accelerates lipid accumulation. In recent years, the potential of miRNA as a biomarker for early diagnosis and as a target for therapeutic intervention in AS has gained considerable attention. Although miRNA-based strategies have shown encouraging results in preclinical studies, their clinical translation is still limited by inadequate delivery efficiency and off-target effects. Future research should prioritize the development of efficient and highly specific delivery platforms, as well as the integration of miRNA-based therapies with other treatment modalities, to pave the way for precision management of atherosclerosis.