Cancer and heart failure: prevalence, incidence, and prognosis in Scotland.
Antonio, I., I, M.M., M, F.J., Pierpaolo, P., P, E.B.M., N, L.N., P, P.J., Jim, L., F, M.D., Ruth, D., B, T.T.Q., Denise, B., K, H.F., E, H.C., Michael, F., E, G.C., Alan, S., Clea, d.T., Sandosh, P., . . . F, C.J.G. (2026). Cancer and heart failure: prevalence, incidence, and prognosis in Scotland.. Eur Heart J. https://doi.org/10.1093/eurheartj/ehag120
Antonio I, I MM, M FJ, Pierpaolo P, P EBM, N LN, et al. Cancer and heart failure: prevalence, incidence, and prognosis in Scotland.. Eur Heart J. 2026; doi: 10.1093/eurheartj/ehag120
Antonio I, I MM, M FJ, et al. Cancer and heart failure: prevalence, incidence, and prognosis in Scotland.[J]. Eur Heart J. 2026. DOI: 10.1093/eurheartj/ehag120.
@article{antonio2026,
author = {Iaconelli Antonio and Morsy Moustafa I and Friday Jocelyn M and Pellicori Pierpaolo and Elyan Benjamin M P and Lang Ninian N and Pell Jill P and Lewsey Jim and Mackay Daniel F and Dundas Ruth and Tran Tran Q B and Brown Denise and Ho Frederick K and Hastie Claire E and Fleming Michael and Geue Claudia E and Stevenson Alan and du Toit Clea and Padmanabhan Sandosh and Maffia Pasquale and Sensini Luca and Feccia Maria Vittoria and Pecorini Giovanni and Anker Stefan D and Anker Markus S and Crea Filippo and Cleland John G F},
title = {Cancer and heart failure: prevalence, incidence, and prognosis in Scotland.},
journal = {Eur Heart J},
year = {2026},
doi = {10.1093/eurheartj/ehag120},
note = {PMID: 42068332},
}
TY - JOUR AU - Iaconelli Antonio AU - Morsy Moustafa I AU - Friday Jocelyn M AU - Pellicori Pierpaolo AU - Elyan Benjamin M P AU - Lang Ninian N AU - Pell Jill P AU - Lewsey Jim AU - Mackay Daniel F AU - Dundas Ruth AU - Tran Tran Q B AU - Brown Denise AU - Ho Frederick K AU - Hastie Claire E AU - Fleming Michael AU - Geue Claudia E AU - Stevenson Alan AU - du Toit Clea AU - Padmanabhan Sandosh AU - Maffia Pasquale AU - Sensini Luca AU - Feccia Maria Vittoria AU - Pecorini Giovanni AU - Anker Stefan D AU - Anker Markus S AU - Crea Filippo AU - Cleland John G F TI - Cancer and heart failure: prevalence, incidence, and prognosis in Scotland. T2 - Eur Heart J PY - 2026 DO - 10.1093/eurheartj/ehag120 AN - PMID:42068332 ER -
Many patients with cancer develop heart failure (HF), and many patients with HF develop cancer. Inter-relationships between their natural histories are rarely reported. Health records were obtained for a Scottish region. People aged >50 years were classified by the presence or absence of HF, loop diuretics (a pharmacological marker of congestion), and cancer. Incident cancer, mortality, and cause of death were recorded. Of 317 178 people aged >50 years, 11 268 (3.6%) had HF of whom 6276 were prescribed loop diuretics; a further 19 044 (6.0%) received loop diuretics. Thus, 30 312 (9.6%) people met an expanded definition of heart failure (HFexp). Annual cancer incidence was slightly higher for those with HFexp (incidence rate ratio 1.10; P < .001), varying amongst cancer types. For people with neither cancer nor HFexp, mortality was <3% annually; most deaths were cardiovascular. For those with cancer but not HFexp, annual mortality was 6.3% for women and 9.0% for men; most died of cancer. For those with HFexp but not cancer, annual mortality ranged from 6.6% to 18.4% depending on sex and HFexp criteria applied; most deaths were cardiovascular. For those with both cancer and HFexp, annual mortality ranged from 14.5% to 28.4%; cardiovascular and cancer mortality rates were similar. Few patients died at home (∼20%). Patients with HFexp have a slightly higher risk of cancer overall, but this may vary according to cancer type. Patients with both cancer and HFexp have a poor prognosis with a similar proportion of deaths attributed to cancer and cardiovascular disease.