Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study.
I, W. (2026). Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study.. In vivo (Athens, Greece). https://doi.org/10.21873/invivo.14390
I W. Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study.. In vivo (Athens, Greece). 2026; doi: 10.21873/invivo.14390
I W. Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study.[J]. In vivo (Athens, Greece). 2026. DOI: 10.21873/invivo.14390.
@article{i2026,
author = {Wakabayashi I},
title = {Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study.},
journal = {In vivo (Athens, Greece)},
year = {2026},
doi = {10.21873/invivo.14390},
note = {PMID: 42379787},
}
TY - JOUR AU - Wakabayashi I TI - Atrial Fibrillation and Lipid-related Indices in Japanese Men: An Age-matched Case-control Study. T2 - In vivo (Athens, Greece) PY - 2026 DO - 10.21873/invivo.14390 AN - PMID:42379787 ER -
BACKGROUND/AIM: Atrial fibrillation (AF) is associated with cardiovascular risk factors. Although certain lipid-related indices, including the ratio of low-density lipoprotein (LDL) cholesterol to high-density lipoprotein (HDL) cholesterol (LDL-C/HDL-C), the ratio of triglycerides to HDL-C (TG/HDL-C), lipid accumulation product (LAP), cardiometabolic index (CMI) and the ratio of gamma-glutamyltransferase to HDL-C (GGT/HDL-C), are known to predict cardiovascular disease, their relationship with AF is unclear. PATIENTS AND METHODS: The participants included 154 men (median of age: 66 years) with AF and 308 age-matched men without AF. Cardiovascular risk factors, including obesity indices, blood pressure, blood lipids and hemoglobin A1C, as well as lipid-related indices, were compared between the groups with and without AF. RESULTS: Body mass index, waist circumference and GGT were significantly higher or larger in participants with AF than in those without AF, while LDL-C was significantly lower in the AF group than in the control group. TG, HDL-C and hemoglobin A1C were not significantly different between the two groups. LAP and GGT/HDL-C were significantly higher and LDL-C/HDL-C was significantly lower in the AF group than in the control group, whereas TG/HDL-C and CMI were not significantly different between the two groups. Then, a new lipid-related index (AF risk index: AFRI), defined as the product of waist circumference and GGT divided by LDL-C, was proposed and shown to be associated with AF more strongly than each cardiovascular risk factor alone. CONCLUSION: LAP and GGT/HDL-C were positively associated with AF, whereas LDL-C/HDL-C was inversely associated with AF. AFRI may be a useful marker for discriminating the risk of AF.