Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.
A, B.D., K, B., M, B., JH, S., S, W., L, P., HT, S., TL, L., & M, S. (2026). Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.. European journal of clinical pharmacology. https://doi.org/10.1007/s00228-026-04132-5
A BD, K B, M B, JH S, S W, L P, et al. Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.. European journal of clinical pharmacology. 2026; doi: 10.1007/s00228-026-04132-5
A BD, K B, M B, et al. Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.[J]. European journal of clinical pharmacology. 2026. DOI: 10.1007/s00228-026-04132-5.
@article{a2026,
author = {Bech-Drewes A and Bonnesen K and Böttcher M and Søby JH and Winther S and Pedersen L and Sørensen HT and Lash TL and Schmidt M},
title = {Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.},
journal = {European journal of clinical pharmacology},
year = {2026},
doi = {10.1007/s00228-026-04132-5},
note = {PMID: 42426382},
}
TY - JOUR AU - Bech-Drewes A AU - Bonnesen K AU - Böttcher M AU - Søby JH AU - Winther S AU - Pedersen L AU - Sørensen HT AU - Lash TL AU - Schmidt M TI - Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease. T2 - European journal of clinical pharmacology PY - 2026 DO - 10.1007/s00228-026-04132-5 AN - PMID:42426382 ER -
PURPOSE: We examined temporal trends in NSAID use among patients referred for evaluation of suspected coronary artery disease (CAD). METHODS: We conducted a drug utilisation study using population-based healthcare data from Western Denmark, covering 3.3 million inhabitants. Three cohorts were categorised based on first-time diagnostic procedure for CAD assessment: coronary computed tomography angiography (CCTA; 2008-2022, n = 91,230), myocardial perfusion imaging (MPI; 2016-2022, n = 17,044), and all invasive coronary angiograms (ICA; 2008-2022, n = 128,327). We calculated the one-year prevalence proportion of NSAID use after the diagnostic procedures, stratified by procedure-defined CAD severity. RESULTS: NSAID use declined over the study period, regardless of CAD severity in patients undergoing CCTA or ICA (p < 0.001). In 2021, the one-year prevalence of NSAID use was 17% among patients with severe CAD vs. 24% among patients without CAD diagnosed using CCTA (prevalence proportion ratio [PPR] 0.73, 95% confidence interval [CI]: 0.60-0.90). In patients undergoing MPI, 9% of those with severe CAD vs. 15% of those with no CAD used NSAIDs (PPR 0.58, 95% CI: 0.45-0.73). In patients undergoing ICA, 10% of those with severe CAD and 20% of those with no CAD used NSAIDs (PPR 0.53, 95% CI: 0.44-0.62). CONCLUSION: Although NSAID use among patients with CAD has decreased and is lower than among patients without CAD, it remains relatively high in those with severe CAD.