Effect and Clinical Characteristics of Human Cytomegalovirus Infection on Vascular Inflammation in Patients With Coronary Atherosclerotic Heart Disease.
H, H., H, L., P, L., & W, Z. (2026). Effect and Clinical Characteristics of Human Cytomegalovirus Infection on Vascular Inflammation in Patients With Coronary Atherosclerotic Heart Disease.. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. https://doi.org/10.1111/apm.70229
H H, H L, P L, W Z. Effect and Clinical Characteristics of Human Cytomegalovirus Infection on Vascular Inflammation in Patients With Coronary Atherosclerotic Heart Disease.. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2026; doi: 10.1111/apm.70229
H H, H L, P L, et al. Effect and Clinical Characteristics of Human Cytomegalovirus Infection on Vascular Inflammation in Patients With Coronary Atherosclerotic Heart Disease.[J]. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2026. DOI: 10.1111/apm.70229.
@article{h2026,
author = {Huang H and Liu H and Liu P and Zhang W},
title = {Effect and Clinical Characteristics of Human Cytomegalovirus Infection on Vascular Inflammation in Patients With Coronary Atherosclerotic Heart Disease.},
journal = {APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
year = {2026},
doi = {10.1111/apm.70229},
note = {PMID: 42460793},
}
TY - JOUR AU - Huang H AU - Liu H AU - Liu P AU - Zhang W TI - Effect and Clinical Characteristics of Human Cytomegalovirus Infection on Vascular Inflammation in Patients With Coronary Atherosclerotic Heart Disease. T2 - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica PY - 2026 DO - 10.1111/apm.70229 AN - PMID:42460793 ER -
This study evaluated the impact of human cytomegalovirus (HCMV) infection on vascular inflammation and clinical characteristics in patients with coronary atherosclerotic heart disease (CHD). A total of 180 CHD patients with HCMV infection (research group) and 90 CHD patients without HCMV infection (control group) were enrolled. Serum levels of hs-CRP, TNF-α, IL-6, and Lp-PLA2 were measured, and clinical data were collected. The research group showed significantly higher inflammatory marker levels than controls (p < 0.05). Mean viral load was 4.58 ± 1.01 copies/mL, and high-load patients had higher marker levels than low-load patients (p < 0.05). Significant between-group differences were observed in CHD severity, number of diseased vessels, stenosis degree, cardiac function, angina grade, and carotid atherosclerosis (p < 0.05). HCMV viral load was positively correlated with all inflammatory markers and clinical severity indices (p < 0.05). These findings indicate that HCMV infection is associated with exacerbated vascular inflammation and worse CHD progression, suggesting the need for timely antiviral intervention.