Thyrotoxic periodic paralysis presenting with transient ventricular arrhythmia: a rare variant presentation of Graves' disease.
P, M., I, G., & A, D. (2026). Thyrotoxic periodic paralysis presenting with transient ventricular arrhythmia: a rare variant presentation of Graves' disease.. BMJ case reports. https://doi.org/10.1136/bcr-2025-267568
P M, I G, A D. Thyrotoxic periodic paralysis presenting with transient ventricular arrhythmia: a rare variant presentation of Graves' disease.. BMJ case reports. 2026; doi: 10.1136/bcr-2025-267568
P M, I G, A D. Thyrotoxic periodic paralysis presenting with transient ventricular arrhythmia: a rare variant presentation of Graves' disease.[J]. BMJ case reports. 2026. DOI: 10.1136/bcr-2025-267568.
@article{p2026,
author = {Makashir P and Gupta I and Darak A},
title = {Thyrotoxic periodic paralysis presenting with transient ventricular arrhythmia: a rare variant presentation of Graves' disease.},
journal = {BMJ case reports},
year = {2026},
doi = {10.1136/bcr-2025-267568},
note = {PMID: 42463171},
}
TY - JOUR AU - Makashir P AU - Gupta I AU - Darak A TI - Thyrotoxic periodic paralysis presenting with transient ventricular arrhythmia: a rare variant presentation of Graves' disease. T2 - BMJ case reports PY - 2026 DO - 10.1136/bcr-2025-267568 AN - PMID:42463171 ER -
Thyrotoxic periodic paralysis (TPP) is a rare variant presentation associated with thyrotoxicosis. It is characterised by acute hypokalaemic paralysis due to intracellular potassium shift. We describe a man in his early 30s who presented with sudden-onset flaccid quadriparesis and transient self-reverted broad-complex tachycardia. Arterial blood gas analysis revealed severe hypokalaemia (1.2 mmol/L; reference range 3.5-5.1 mmol/L). Thyroid function tests demonstrated suppressed thyroid-stimulating hormone (<0.01 mIU/L; reference range 0.4-4.0 mIU/L) with markedly elevated free triiodothyronine and thyroxine levels, consistent with thyrotoxicosis due to Graves' disease. He was treated with cautious intravenous potassium replacement and initiation of antithyroid therapy with beta-blockade, resulting in rapid and complete neurological recovery. This case underscores the importance of recognising TPP as a distinct clinical presentation of thyrotoxicosis in young men presenting with acute paralysis and cardiac arrhythmia.