HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study.
M, N., J, G., X, H., Y, D., H, W., Y, Z., D, Z., Z, W., F, Q., & F, W. (2026). HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study.. PloS one. https://doi.org/10.1371/journal.pone.0353906
M N, J G, X H, Y D, H W, Y Z, et al. HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study.. PloS one. 2026; doi: 10.1371/journal.pone.0353906
M N, J G, X H, et al. HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study.[J]. PloS one. 2026. DOI: 10.1371/journal.pone.0353906.
@article{m2026,
author = {Niu M and Gao J and Han X and Dong Y and Wang H and Zhang Y and Zhao D and Wang Z and Qi F and Wang F},
title = {HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study.},
journal = {PloS one},
year = {2026},
doi = {10.1371/journal.pone.0353906},
note = {PMID: 42490569},
}
TY - JOUR AU - Niu M AU - Gao J AU - Han X AU - Dong Y AU - Wang H AU - Zhang Y AU - Zhao D AU - Wang Z AU - Qi F AU - Wang F TI - HLA-DRB1 and HLA-DQB1 genetic polymorphisms and susceptibility to coronary atherosclerosis in a Northeast Chinese Population: A case-control study. T2 - PloS one PY - 2026 DO - 10.1371/journal.pone.0353906 AN - PMID:42490569 ER -
Atherosclerosis is a chronic inflammatory disease with increasing prevalence in Northeast China, where HLA class II molecules play an important immunoregulatory role. However, the contribution of specific HLA-DRB1 and HLA-DQB1 alleles to AS susceptibility in this population remains incompletely characterized, necessitating novel biomarkers for early detection. In this case-control study of 209 participants, HLA-DRB1 and HLA-DQB1 allele and phenotypic haplotype distributions were compared using odds ratios with 95% confidence intervals and Bonferroni correction for multiple comparisons. A total of 28 HLA-DRB1 and 12 HLA-DQB1 alleles were analyzed. The lowest P value for HLA-DRB1 was observed for DRB1*07:01 (P = 0.077, corrected P = 1.000; OR = 1.994, 95% CI: 0.955-4.164), and that for HLA-DQB1 was observed for DQB1*02:02 (P = 0.150, corrected P = 1.000; OR = 1.739, 95% CI: 0.850-3.558). Neither reached statistical significance, though both trended upward in the AS-susceptible group (DRB1*07:01: 12.59% vs. 6.76%; DQB1*02:02: 12.22% vs. 7.43%). The DRB1*07:01-DQB1*02:02 phenotypic haplotype was more frequent in the AS-susceptible group than in the control group (22.22% vs. 10.81%), with an OR of 2.357 (95% CI: 1.019-5.452). Although the association did not survive Bonferroni correction (corrected P = 1.000), the effect size suggested the signal was unlikely to be a trivial statistical artifact. In conclusion, the DRB1*07:01-DQB1*02:02 phenotypic haplotype was identified as a candidate risk marker for AS in the Northeast Chinese population, warranting validation in larger cohorts.