Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.
P, L., X, Z., W, Z., L, Z., & L, L. (2026). Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.. Yonsei medical journal. https://doi.org/10.3349/ymj.2024.0525
P L, X Z, W Z, L Z, L L. Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.. Yonsei medical journal. 2026; doi: 10.3349/ymj.2024.0525
P L, X Z, W Z, et al. Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.[J]. Yonsei medical journal. 2026. DOI: 10.3349/ymj.2024.0525.
@article{p2026,
author = {Li P and Zhu X and Zheng W and Zhang L and Liu L},
title = {Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.},
journal = {Yonsei medical journal},
year = {2026},
doi = {10.3349/ymj.2024.0525},
note = {PMID: 42494271},
}
TY - JOUR AU - Li P AU - Zhu X AU - Zheng W AU - Zhang L AU - Liu L TI - Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis. T2 - Yonsei medical journal PY - 2026 DO - 10.3349/ymj.2024.0525 AN - PMID:42494271 ER -
PURPOSE: Numerous studies have shown that the atherogenic index of plasma (AIP) is a strong predictor of the risk of cardiovascular diseases (CVDs) and an independent predictor of cardiovascular events (CEs) and related mortality. The predictive value of AIP for in-hospital mortality (IHM) in individuals with sepsis remains uncertain. Therefore, this study aimed to investigate the association between AIP and IHM among patients with sepsis using a large sample from the Medical Information Mart for Intensive Care (MIMIC) database. MATERIALS AND METHODS: Individuals with sepsis were identified from the MIMIC-IV database and categorized into four groups according to AIP quartiles. The IHM was the primary outcome. The association between AIP and IHM was evaluated using logistic regression and restricted cubic spline (RCS) models. RESULTS: A total of 2243 patients (59% male) were included this study. In univariable logistic regression, higher AIP was significantly associated with increased IHM (odds ratio: 1.18 [95% confidence interval: 1.05-1.33]; p of Wald test=0.005). The RCS model showed no evidence of a nonlinear association between AIP and IHM (p for nonlinearity>0.05). Sensitivity analysis demonstrated consistent findings regarding the magnitude and direction of the effects across different subgroups, indicating stable results. CONCLUSION: Elevated AIP was associated with higher IHM in individuals with sepsis.