Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study.
A, R.G., J, P.A., R, G.M., JC, C.D., M, C.C., M, P.Á.O., M, A.S., & J, L.A. (2026). Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study.. Medical sciences (Basel, Switzerland). https://doi.org/10.3390/medsci14030402
A RG, J PA, R GM, JC CD, M CC, M PÁO, et al. Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study.. Medical sciences (Basel, Switzerland). 2026; doi: 10.3390/medsci14030402
A RG, J PA, R GM, et al. Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study.[J]. Medical sciences (Basel, Switzerland). 2026. DOI: 10.3390/medsci14030402.
@article{a2026,
author = {Roldan-Guerra A and Perea-Armijo J and González-Manzanares R and Castillo-Domínguez JC and Crespin-Crespin M and Pan-Álvarez Ossorio M and Anguita-Sánchez M and López-Aguilera J},
title = {Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study.},
journal = {Medical sciences (Basel, Switzerland)},
year = {2026},
doi = {10.3390/medsci14030402},
note = {PMID: 42506371},
}
TY - JOUR AU - Roldan-Guerra A AU - Perea-Armijo J AU - González-Manzanares R AU - Castillo-Domínguez JC AU - Crespin-Crespin M AU - Pan-Álvarez Ossorio M AU - Anguita-Sánchez M AU - López-Aguilera J TI - Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study. T2 - Medical sciences (Basel, Switzerland) PY - 2026 DO - 10.3390/medsci14030402 AN - PMID:42506371 ER -
INTRODUCTION: Abnormal serum potassium levels are a common issue in patients with heart failure with reduced ejection fraction (HFrEF), limiting the use of prognostically beneficial therapies. The primary aim of this study was to characterise the HFrEF population according to baseline potassium levels and to assess their impact on medium- to long-term prognosis. METHODS: A retrospective study was conducted on a cohort of consecutive patients with HFrEF recruited at our centre. Patients were classified according to baseline serum potassium levels into: Group 1 (<3.5 mEq/L), Group 2 (3.5-5.0 mEq/L), and Group 3 (>5.0 mEq/L). Prognostic impact was assessed in terms of HF readmissions, HF mortality and all-cause mortality. RESULTS: A total of 409 patients were analysed. The median age was 69 years [IQR 59-77], with a predominance of male patients (74.1%). There were 26 patients (6.36%) with hypokalaemia, 365 (89.24%) with normokalaemia, and 18 (4.4%) with hyperkalaemia. Group 1 showed a higher prevalence of diabetes mellitus (69.2% vs. 47.4% vs. 33.4%; p = 0.043) and a greater proportion of patients with ≥2 previous admissions for HF (25% vs. 10.5% vs. 0%; p = 0.008). No differences were observed regarding echocardiographic parameters, markers of congestion, or HFrEF treatment. After a median follow-up of 60 months, no significant differences were found between groups in rates of HF readmissions, HF mortality and all-cause mortality. CONCLUSIONS: Patients with hypokalaemia exhibited a higher prevalence of diabetes mellitus and previous HF admissions. In our population, no differences were observed between groups in the use of prognostically beneficial therapies or in outcomes in terms of HF rehospitalisations and mortality.