Effects of Antiarrhythmics on Cardiac Phenotype and Redox Balance in Spontaneously Hypertensive Rats.
SM, S., IM, S., GT, D., MD, M., SL, M., MP, R., MM, A., MR, N., KG, M., & ND, L. (2026). Effects of Antiarrhythmics on Cardiac Phenotype and Redox Balance in Spontaneously Hypertensive Rats.. International journal of molecular sciences. https://doi.org/10.3390/ijms27146490
SM S, IM S, GT D, MD M, SL M, MP R, et al. Effects of Antiarrhythmics on Cardiac Phenotype and Redox Balance in Spontaneously Hypertensive Rats.. International journal of molecular sciences. 2026; doi: 10.3390/ijms27146490
SM S, IM S, GT D, et al. Effects of Antiarrhythmics on Cardiac Phenotype and Redox Balance in Spontaneously Hypertensive Rats.[J]. International journal of molecular sciences. 2026. DOI: 10.3390/ijms27146490.
@article{sm2026,
author = {Simović SM and Srejović IM and Davidović GT and Murić MD and Mitrović SL and Ravić MP and Andjić MM and Nikolić MR and Mihajlović KG and Lazarević ND},
title = {Effects of Antiarrhythmics on Cardiac Phenotype and Redox Balance in Spontaneously Hypertensive Rats.},
journal = {International journal of molecular sciences},
year = {2026},
doi = {10.3390/ijms27146490},
note = {PMID: 42511832},
}
TY - JOUR AU - Simović SM AU - Srejović IM AU - Davidović GT AU - Murić MD AU - Mitrović SL AU - Ravić MP AU - Andjić MM AU - Nikolić MR AU - Mihajlović KG AU - Lazarević ND TI - Effects of Antiarrhythmics on Cardiac Phenotype and Redox Balance in Spontaneously Hypertensive Rats. T2 - International journal of molecular sciences PY - 2026 DO - 10.3390/ijms27146490 AN - PMID:42511832 ER -
Arterial hypertension is a well-known risk factor for cardiac arrhythmias, while certain antihypertensive agents may also create conditions for arrhythmia occurrence. The aim of this study was to evaluate the effects of selected class III antiarrhythmic drugs on cardiac function and structure, as well as on oxidative stress status, in spontaneously hypertensive rats (SHRs). Male SHRs were treated for 4 weeks with dronedarone, amiodarone, or dofetilide. Cardiac function was assessed in vivo by echocardiography and ex vivo using the Langendorff model. Oxidative stress markers, myocardial morphology, and HSP70 and SERCA2 expression were analyzed. All drugs partially improved cardiac function in vivo, with dronedarone exerting the strongest antihypertensive effect. Ex vivo, dofetilide enhanced contractility and dronedarone reduced cardiac performance, whereas amiodarone showed intermediate effects. Oxidative stress was differentially modulated, with dofetilide and amiodarone improving antioxidant defenses, while dronedarone showed heterogeneous effects. Histologically, dofetilide preserved myocardial architecture most effectively, while amiodarone and dronedarone partially attenuated hypertensive remodeling. Treatments decreased HSP70 expression, while increasing SERCA2 expression, particularly in the dofetilide group. Class III antiarrhythmic drugs differentially affect cardiac function, redox balance, calcium handling, and myocardial remodeling in hypertension, which may contribute to their distinct antiarrhythmic and cardioprotective properties.