False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.
E, P., Ö, G., & C, G. (2026). False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.. Cardiovascular journal of Africa. https://doi.org/10.5830/CVJA-2026-031
E P, Ö G, C G. False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.. Cardiovascular journal of Africa. 2026; doi: 10.5830/CVJA-2026-031
E P, Ö G, C G. False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.[J]. Cardiovascular journal of Africa. 2026. DOI: 10.5830/CVJA-2026-031.
@article{e2026,
author = {Polat E and Güler Ö and Güngör C},
title = {False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman.},
journal = {Cardiovascular journal of Africa},
year = {2026},
doi = {10.5830/CVJA-2026-031},
note = {PMID: 42578359},
}
TY - JOUR AU - Polat E AU - Güler Ö AU - Güngör C TI - False-negative 99mTc-PYP bone scintigraphy in early cardiac amyloidosis: a rapidly progressive case in a young woman. T2 - Cardiovascular journal of Africa PY - 2026 DO - 10.5830/CVJA-2026-031 AN - PMID:42578359 ER -
Cardiac amyloidosis is one of the aetiologies of treatable heart failure. Cardiac amyloidosis is rare in young patients, but it can present atypically, leading to diagnostic delays. In this case, a 33-year-old female patient presenting with dyspnoea underwent echocardiography and cardiac magnetic resonance imaging, which showed left ventricular hypertrophy and raised suspicion for amyloidosis; however, no uptake was observed on technetium-99m pyrophosphate (99mTc-PYP) bone scintigraphy. Fourteen months later, the patient presented with decompensated heart failure and was diagnosed with cardiac amyloidosis based on Grade 2 uptake on repeat 99mTc-PYP bone scintigraphy, with an ejection fraction of 25%. As illustrated in this case, negative imaging findings in the early stages do not rule out a diagnosis of cardiac amyloidosis.